DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and SOX17

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_071899.1	Gene:	SOX17 / 64321	HGNCID:	18122	Length:	414	Species:	Homo sapiens

Alignment Length:	631	Identity:	130/631 - (20%)
Similarity:	187/631 - (29%)	Gaps:	247/631 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1156 GISANSKKQTAAMRLPTHNSNI------RKLEECHDDGAAG-APATSAAKRRSQSLSALQQQQQQ 1213
            |.:::.:.||.: .||...:.:      ..|....|....| |||.|.|
Human     7 GYASDDQSQTQS-ALPAVMAGLGPCPWAESLSPIGDMKVKGEAPANSGA---------------- 54

  Fly  1214 QQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQK 1278
              .|||||.|.|:   .:|||||||||:::|..||.:.:::|:..|..:||:||:.|.||...:|
Human    55 --PAGAAGRAKGE---SRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEK 114

  Fly  1279 AQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASG-----AAGTGDAKQRLVSVDG 1338
            ..:.|.|..::..|.:.||.:|:..:.|::........||...|     ||..|
Human   115 RPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGGFLHGLAEPQAAALG----------- 168

  Fly  1339 SDSLEHDMCPSTPGGSGSCGGQGISSDLQG-----DIIPLTIDNYNSTCDEAPTTISMKGNGNGK 1398
                       ..||..:..|.|:....||     .::|..:..:...|...         |...
Human   169 -----------PEGGRVAMDGLGLQFPEQGFPAGPPLLPPHMGGHYRDCQSL---------GAPP 213

  Fly  1399 LMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSAEEHS 1463
            |....||:.                                 |.:|.|.....|
Human   214 LDGYPLPTP---------------------------------DTSPLDGVDPDP----------- 234

  Fly  1464 TSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVTPFQPT 1528
                   |..|.|:.|.      .|.|         ....|.|:|   .|..|..|       |.
Human   235 -------AFFAAPMPGD------CPAA---------GTYSYAQVS---DYAGPPEP-------PA 267

  Fly  1529 GGAFKSMPISPKGSGGKPEDAG-SLQAHIKQEDIKQEPPSPYKLNNGS-GSASGGGVVSAPPPNS 1591
            |      |:.|:..   ||.|| |:...:       .|||...:..|: ||...||
Human   268 G------PMHPRLG---PEPAGPSIPGLL-------APPSALHVYYGAMGSPGAGG--------- 307

  Fly  1592 GSVGAIFNFNVPTATALSQKQFHYPMHHPHRSPTDLRAAHQACVPSSPAGMGLGHAANIATPPAS 1656
               |..|..         |.|..:...|.|..|.          |..|:...........|.| |
Human   308 ---GRGFQM---------QPQHQHQHQHQHHPPG----------PGQPSPPPEALPCRDGTDP-S 349

  Fly  1657 APAQIMGGGPAS---QKMFFAMTHPYTLLQRSHQPGTPSLEHLQLDAFAPGGYTLRNHNGLSSLP 1718
            .||:::|....:   |.:.|.......|..:.|..|.
Human   350 QPAELLGEVDRTEFEQYLHFVCKPEMGLPYQGHDSGV---------------------------- 386

  Fly  1719 PPVSAQPTMLLHGYPPSHGVEPPARSPSYKSMPSTPKSATYLMSAP 1764
                        ..|.|||        :..|:.|...||.|..:.|
Human   387 ------------NLPDSHG--------AISSVVSDASSAVYYCNYP 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	28/70 (40%)
SOX17	NP_071899.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..66		15/50 (30%)
		SOX-TCF_HMG-box	67..138	CDD:238684	28/70 (40%)
		Sox_C_TAD	201..412	CDD:288887	67/391 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..286		13/48 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..352		14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910