DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cic and BBX

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	XP_024309412.1	Gene:	BBX / 56987	HGNCID:	14422	Length:	953	Species:	Homo sapiens

Alignment Length:	1087	Identity:	220/1087 - (20%)
Similarity:	335/1087 - (30%)	Gaps:	388/1087 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1185 DDGAAGAPATSAAKRR--------SQSLSALQQQQQQQ---------QQAGAAG-------TAAG 1225
            |..|.|.......||:        ::.|....::::::         |..||.|       |...
Human    21 DHSAEGEGVGKRPKRKCLQWHPLLAKKLLDFSEEEEEEDEEEDIDKVQLLGADGLEQDVGETEDD 85

  Fly  1226 QPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKD 1290
            :...::.|||||||::|.|:||.:|.::||..|||..:|||.:||..|.|::|.:|.::|...||
Human    86 ESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKD 150

  Fly  1291 AHFKLHPEWKWCSKDRR--KSSTSTATPGGKASGAAGTGDAKQRLVS-----VDGSDSLEHDMCP 1348
            |..|.:|.:|||....:  ||.|.|..|..|.  .|...|:.:.|.|     .:....|...|..
Human   151 AFMKANPGYKWCPTTNKPVKSPTPTVNPRKKL--WAFPSDSSRDLPSPKKAKTEEMPQLNFGMAD 213

  Fly  1349 STPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQML 1413
            .|..|       |:|                                                ||
Human   214 PTQMG-------GLS------------------------------------------------ML 223

  Fly  1414 VVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSA----EEHSTSGANGQA--- 1471
            ::..|....|.:.....||..|::|             ||..|:|.    .|.|:|.::..|
Human   224 LLAGEHALGTPEVSSGTCRPDVSES-------------PELRQKSPLFQFAEISSSTSHSDASTK 275

  Fly  1472 --------------INAPPLSGGEREITLKPKAIKAHPVL---ESNMLPYTQMSIYTQYTSPKNP 1519
                          .|...|.|.|             ||.   :|.:....:|.:.::....:..
Human   276 QCQTSALFQFAEISSNTSQLGGAE-------------PVKRCGKSALFQLAEMCLASEGMKMEES 327

  Fly  1520 IGVTPFQPTGGAFKSMPISPKGSGGKPE--------DAGSLQAH--------------------- 1555
            ..:...:..||..|.:      ..||.|        |...||..
Human   328 KLIKAKESDGGRIKEL------EKGKEEKEIKMEKTDETRLQKEAEFEKSAKENLRDSKELRNFE 386

  Fly  1556 ---------IKQED----IKQEPPSPYKLN---NGSGSASGGGVVSAPPPNSGSVGAIFNFNVPT 1604
                     ||.||    .|:|....:|.:   :.|.|||...::|..|
Human   387 ALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIISDVP---------------- 435

  Fly  1605 ATALSQKQFHYPMHHPH-----RSPTDLRAAHQACVPSSPAGMGLGHAANIATPPASAPAQIMGG 1664
                |:|..   |.|||     ..|..|....:.......:.|. .|..:.:||..:.
Human   436 ----SRKDH---MCHPHGIMIIEDPAALNKPEKLKKKKKKSKMD-RHGNDKSTPKKTC------- 485

  Fly  1665 GPASQKMFFAMTHPYTLLQRSHQPGTPSLEHL--QLDAFAPGGYTLRNHNGLSSLP----PPVSA 1723
                               :..|.....:|.:  .::|.|.|.:.:..   |...|    ...|:
Human   486 -------------------KKRQSSESDIESVIYTIEAVAKGDWGIEK---LGDTPRKKVRTSSS 528

  Fly  1724 QPTMLLHGYPPSHGVEPPARSPSYKSMPSTPKSATYLMSAPPERGMDGGMSGCASAAASGGDESD 1788
            ....:|...||...|:...:..|.:....|.|.     |.||:     .:|..||...||.....
Human   529 GKGSILDAKPPKKKVKSREKKMSKEKSSDTTKE-----SRPPD-----FISISASKNISGETPEG 583

  Fly  1789 IDADGQQFILAP-TPAQLGRAPLQRRKNLS-QSKSESNVSFGANLGASNGQHISRKLHSPTMMES 1851
            |.|:       | ||.:....|     :|| |:|.|.:             ...||:.:....:|
Human   584 IKAE-------PLTPMEDALPP-----SLSGQAKPEDS-------------DCHRKIETCGSRKS 623

  Fly  1852 SSPIIGHVNSSNLSSALPTPTSSTTTPNSDEQLPLTPTTSSSNSN--LNQQQPKSPMKGAPGSTA 1914
            .....|.:..:.:|..:.|    :...|.|.....:...:||:..  .|::.......|..||..
Human   624 ERSCKGALYKTLVSEGMLT----SLRANVDRGKRSSGKGNSSDHEGCWNEESWTFSQSGTSGSKK 684

  Fly  1915 -AALKKKNDEMNNSVLKQVDFEKKYKALPQFQP----EDCQSPSAIAVPSSPRVYG--------- 1965
             ...|.|.|.:..|.....:||||:.:|||:.|    ..|     :.||...:..|
Human   685 FKKTKPKEDCLLGSAKLDEEFEKKFNSLPQYSPVTFDRKC-----VPVPRKKKKTGNVSSEPTKT 744

  Fly  1966 -----------------TNYRKKNTAP---------------------PPVQKLMCEDDSIDEPA 1992
                             :.|:.|...|                     .|.:.:..||.:..||.
Human   745 SKGPFQSQKKNLFHKIVSKYKHKKEKPNVPEKGSGDKWSNKQLFLDAIHPTEAIFSEDRNTMEPV 809

  Fly  1993 -----------SAPPTTTQR-FFGPDFNNELKDE-----RLAELESSDQTGRSPRTPKTPLQ--- 2037
                       :..|||||. ..|.......|.:     |.|:...|...|.....||..||
Human   810 HKVKNIPSIFNTPEPTTTQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSL 874

  Fly  2038 --SARSDASEK-GHR-KVLETRRSLVLQLFAEHGNFPTAQATMAFQS 2080
              :..:|.::| .|. :|.|||.|.           |...|..||.|
Human   875 PKATETDCNDKCSHNTEVGETRSST-----------PEMPAVSAFFS 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	33/70 (47%)
BBX	XP_024309412.1	SOX-TCF_HMG-box	91..162	CDD:238684	33/70 (47%)
BBX	XP_024309412.1	DUF2028	203..>335	CDD:312980	30/212 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10281at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910