DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cic and sox5

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	XP_021330769.1	Gene:	sox5 / 567413	ZFINID:	ZDB-GENE-000607-13	Length:	763	Species:	Danio rerio

Alignment Length:	902	Identity:	166/902 - (18%)
Similarity:	282/902 - (31%)	Gaps:	382/902 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 EEYYRTTATSPFQTRPPLAGPSHGSE-QVVQAT---QSHPQQYNGLADI---VISPCSNGQHLKM 572
            :|:.|.::..|       |.|..|:: :||.||   :...::.:|.|.|   :.|.||
Zfish     9 QEFNRMSSKRP-------ASPYGGTDGEVVMATSRQRLEDEEVDGHAVIHLPLSSYCS------- 59

  Fly   573 QQQQQQSSRGYDD----YDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQR 633
             :...:|.|..|.    :.:.|:....|:..||.|     :..|:.|.....|.        |..
Zfish    60 -KVSPRSPRLLDSPPTLHANMDQDGSKGLALSPYA-----QHNSSTSPSKQQQE--------DSS 110

  Fly   634 LTPRSHPATPSAIHRSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCMLCTKESQRRGYCSRH 698
            :.|.|.|.:.||:     .||.| :||.:.:....:::       |::..|...|.:......|.
Zfish   111 MRPGSEPGSASAL-----GTPER-RKGSLADVVDTLKQ-------RKMEELIKNEPEEAPSIERL 162

  Fly   699 LNQKGNTSALPSSTGPGRLLSDSRSSSKTQIDEDTSRDSETSPNY-RVKGRYD---QEETDAAAM 759
            |::......|...:|                            |: .:||..|   ::|.....|
Zfish   163 LSKDWKDKLLAMGSG----------------------------NFGEIKGTPDSLAEKERQLMGM 199

  Fly   760 LVSLSSSRSATPSYTSPVNHAGASPLNAIAHSPVNVSATHRQNFFTPIANQSQQQQQQQPVAVPL 824
            :..|||.|.                         .:.|.|.:. ....|:|.::|:||.
Zfish   200 ITQLSSLRE-------------------------QLLAAHEEQ-KKLAASQIEKQRQQM------ 232

  Fly   825 DSKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSNWEVGSNSNTHVAATAAATSTVGAQPLPPQTT 889
                                               |:.......:|.
Zfish   233 -----------------------------------ELAKQQQDQIAR------------------ 244

  Fly   890 PVSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAPSAPPTSGSSSSHNSVGHATSVIRISSSQQ 954
                      .|||.|||||                                      :|:..||
Zfish   245 ----------QQQQLLQQQH--------------------------------------KINLLQQ 261

  Fly   955 QHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLPPTTVSFHQPNTPTSTAASVASMSQDK 1019
            |.||.|              ||               |||..:....|:..|..||:    :|..
Zfish   262 QIQQVQ--------------GQ---------------LPPLMIPVFPPDQRTLAAAA----AQQG 293

  Fly  1020 MLAKNGYN------APW-FKLLPHMTPMSKASPAPVTPTL------TTSASSYNVVMMQQQQQHQ 1071
            .|...|:|      .|: .:|:|  |.|:.|:.|  ||.|      ...|:....:.:....:|.
Zfish   294 FLLPPGFNYKPGCSEPYPLQLIP--TTMAAAAAA--TPGLGPLQLQQLYAAQLAAMQVSPGAKHS 354

  Fly  1072 QLQQQQ-----------QLQQQQQSPP-------QMPLNHNN----------------------- 1095
            .:.|..           |.::.:.:||       ..|||.::
Zfish   355 TVPQANLATGTLSPTSGQSEKNRSTPPPKPKDEGAQPLNLSSKPKASESKSPTSPASPQVPALKL 419

  Fly  1096 --NHLIVSAPLSSPGKPLNCS-------------MNDAKVAAAAAAAAVANQRQKQQQEEPDDQL 1145
              ..|..|||.|..|.|...|             :||.:....|...|   ::.|:|.:..:..|
Zfish   420 GPGSLKHSAPSSIGGPPSRLSSIDLLSSITSAGYLNDHEAVTKAFQEA---RKMKEQLKREEQVL 481

  Fly  1146 DDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEECHDDGAAGAPATSAAKRRSQSLSALQQQ 1210
            |..|  .....:|.|:.:          :..:|.:|:.                   :|.:|.||
Zfish   482 DAKV--AAVNSLSLNNGR----------SEKVRFMEKA-------------------ALESLSQQ 515

  Fly  1211 QQQQQQA---------GAAGTAAGQP----------------ANKKIRRPMNAFMIFSKKHRKMV 1250
            .:|.:::         |.:|.:.|.|                :...|:|||||||:::|..|:.:
Zfish   516 LKQSEESKFTHAMMDFGISGDSDGSPSVSDSRIFREARGRGSSEPHIKRPMNAFMVWAKDERRKI 580

  Fly  1251 HKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRR 1307
            .:..|:..|..:|||||..|.::...:|..|:|..:.:...|.:.:|::|:..:.:|
Zfish   581 LQAFPDMHNSNISKILGSRWKSMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKR 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	24/70 (34%)
sox5	XP_021330769.1	SSL_OB	332..>415	CDD:332684	9/82 (11%)
sox5	XP_021330769.1	SOX-TCF_HMG-box	561..632	CDD:238684	24/70 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000