DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and sox1b

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001032751.1	Gene:	sox1b / 562710	ZFINID:	ZDB-GENE-060322-5	Length:	340	Species:	Danio rerio

Alignment Length:	450	Identity:	91/450 - (20%)
Similarity:	140/450 - (31%)	Gaps:	168/450 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1212 QQQQQAGAAGTAAGQPANK-KIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKP 1275
            |.....|..|..:|...|: :::|||||||::|:..|:.:.:::|...|..:||.||..|..:..
Zfish    16 QTNTNTGHTGPNSGSKVNQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLMSE 80

  Fly  1276 EQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSST-----STATPGGKASGAAGTGDAKQRLVS 1335
            .:|..:.:.|..::..|.|.||::|:  :.|||:.|     ..:..||..:|:.|.|....
Zfish    81 AEKRPFIDEAKRLRAMHMKEHPDYKY--RPRRKTKTLLKKDKYSLAGGLLAGSGGGGGVGL---- 139

  Fly  1336 VDGSDSLEHDMCPSTPGGSGSCG-GQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKL 1399
                             |.|:.| ||.:.|         .:.:..||   |.:...|.|..||.
Zfish   140 -----------------GMGAAGVGQRLES---------PVGHGGST---AASYAHMNGWTNGA- 174

  Fly  1400 MKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSAEEHST 1464
                                                           |..|...|...:|.....
Zfish   175 -----------------------------------------------YSGQVAAAAAAAAMMQEA 192

  Fly  1465 SGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNP-------IGV 1522
            ..|.||    .|.||....                          :..:..|.||       :..
Zfish   193 QLAYGQ----HPGSGAHHH--------------------------HGHHHHPHNPQPMHRYEMTA 227

  Fly  1523 TPFQPTGGAFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASG-----GG 1582
            ..:.|...:...|..||.|.||.     |...|                .|.|.::||     |.
Zfish   228 LQYSPLSNSQSYMSASPSGYGGI-----SYTQH----------------QNSSVASSGAIGALGS 271

  Fly  1583 VVSAPP------------PNSGSVGAIFNFNVPTATA---LSQKQFHYPMHHPHRSPTDL 1627
            :|.:.|            |.||.:..:.:..:|||.|   ..|.:.|....|...|.|.:
Zfish   272 LVKSEPSVSPPVNAHSRAPCSGDLREMISMYLPTAEAGDPSVQSRLHAVPQHYQSSTTSV 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	23/70 (33%)
sox1b	NP_001032751.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		5/18 (28%)
		SOX-TCF_HMG-box	36..107	CDD:238684	23/72 (32%)
		SOXp	106..>198	CDD:289133	27/174 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..219		7/50 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910