DRSC/TRiP Functional Genomics Resources

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Protein Alignment cic and SOX6

DIOPT Version :9

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:NP_001139291.2 Gene:SOX6 / 55553 HGNCID:16421 Length:828 Species:Homo sapiens


Alignment Length:1076 Identity:208/1076 - (19%)
Similarity:343/1076 - (31%) Gaps:400/1076 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   522 ATSPFQTRPPLAGPSHGSEQVVQATQSHPQQYNGLADIVIS--PCSNGQHLKMQQQQ-------- 576
            |||||      |..:.|.:.:.|...|..:: .|....|.|  |.....|.|...::        
Human     6 ATSPF------ACAADGEDAMTQDLTSREKE-EGSDQHVASHLPLHPIMHNKPHSEELPTLVSTI 63

  Fly   577 QQSSRGYDDYDS--------DDELKRVGIGYS----------PAAGDLDTEKMSACSKRSSMQSR 623
            ||.:    |:||        :.|..::...||          |..|..|.|.|::.:..:..:.:
Human    64 QQDA----DWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRK 124

  Fly   624 GSTSSLLDQRLTPRSHPATPSAIHRSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCMLCTKE 688
            ||.:.::|.....:....|     |::             :.:|...:|...|.|        ||
Human   125 GSLADVVDTLKQKKLEEMT-----RTE-------------QEDSSCMEKLLSKDW--------KE 163

  Fly   689 SQRRGYCSRHLNQ-KGNTSALPSSTGPGRLLSDSRSSSKTQIDEDTSRDSETSPNYRVKGRYDQE 752
            ...|...|..|.: ||...:|.                                         ::
Human   164 KMERLNTSELLGEIKGTPESLA-----------------------------------------EK 187

  Fly   753 ETDAAAMLVSLSSSRSATPSYTSPVNHAGASPLNAIAHSPVNVSATHRQNFFTPIANQSQQQQQQ 817
            |...:.|:..|.|.|....:.........||.:.. ....::::...::.    ||.|.||..||
Human   188 ERQLSTMITQLISLREQLLAAHDEQKKLAASQIEK-QRQQMDLARQQQEQ----IARQQQQLLQQ 247

  Fly   818 Q-----------------PVAVPLDSKWKTT-------------PSPVLYNANNNSSNNNTSSSN 852
            |                 |:.:|:....:.|             |..:.|...:           
Human   248 QHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGD----------- 301

  Fly   853 NNNNSNWEVGSNSNTHVAATAAATSTVGAQPLPPQTTPVSLVMHAPPPQQQPLQ----------- 906
                 |:.|     ..:.:|.||.:..|..||..|...||   |  |...|.|:           
Human   302 -----NYPV-----QFIPSTMAAAAASGLSPLQLQKGHVS---H--PQINQRLKGLSDRFGRNLD 351

  Fly   907 -------QQHHHHQ-----------PPPPPPASLPAPSAPPTSGSSSSHNSVGH---ATSVIRIS 950
                   ..::|.|           ....|.|.:|:...||.:..:.|...:.:   .||.:   
Human   352 TFEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNTAGTVSPTGIKNEKRGTSPV--- 413

  Fly   951 SSQQQHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLPPTTVSFHQPNTPTSTAASVASM 1015
                   .|.:.:..|.|..:.|..:|..||                  ..|.:||...      
Human   414 -------TQVKDEAAAQPLNLSSRPKTAEPV------------------KSPTSPTQNL------ 447

  Fly  1016 SQDKMLAKNGYNAPWFKLLPHMTPMSKASPAPVTPTLTTSA-----SSYNV--------VMMQQQ 1067
                        .|..|..|...|...:.|:|:..:|...:     ||.|.        .:|:..
Human   448 ------------FPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAI 500

  Fly  1068 QQHQQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAAVANQ 1132
            |:.:::::|.|.:||||.|      |.     |...|||..   |..:|..:           |:
Human   501 QEARKMREQIQREQQQQQP------HG-----VDGKLSSIN---NMGLNSCR-----------NE 540

  Fly  1133 RQKQQQE----------EPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEECHDDG 1187
            :::.:.|          ..|.:|...|.:.|.|..:..||    ||     |.:..||::.:...
Human   541 KERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSK----AM-----NGSAAKLQQYYCWP 596

  Fly  1188 AAGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHK 1252
            ..||....|...|.                 |.|.|:.:|   .|:|||||||:::|..|:.:.:
Human   597 TGGATVAEARVYRD-----------------ARGRASSEP---HIKRPMNAFMVWAKDERRKILQ 641

  Fly  1253 KHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPG 1317
            ..|:..|..:|||||..|.::..::|..|:|..:.:...|.:.:|.:|:..:.:|     |....
Human   642 AFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKR-----TCIVD 701

  Fly  1318 GKASGAAGTGDAKQRLVSVDGSDSLEHDM--------CPSTPGGSGSCGGQGISSDLQGDIIP-- 1372
            ||   ....|:.||.:      .|...:|        .|..|..:|:           |.:.|  
Human   702 GK---KLRIGEYKQLM------RSRRQEMRQFFTVGQQPQIPITTGT-----------GVVYPGA 746

  Fly  1373 -----------LTIDNYNSTCDEAP------TTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQ 1420
                       :|.|..:::....|      :|..||.:| |.|..||:.:.|||..:..:.|  
Human   747 ITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDG-GSLAGNEMINGEDEMEMYDDYE-- 808

  Fly  1421 QQTVKKIDLHCRERVNDSDMDDTPFDY--RKQQPEA 1454
                                ||...||  ..:.|||
Human   809 --------------------DDPKSDYSSENEAPEA 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..431 CDD:292708
SOX-TCF_HMG-box 1231..1302 CDD:238684 24/70 (34%)
SOX6NP_001139291.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 14/51 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..470 24/135 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..828 22/95 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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