DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Sox2

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001102651.1	Gene:	Sox2 / 499593	RGDID:	1565646	Length:	319	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	91/380 - (23%)
Similarity:	145/380 - (38%)	Gaps:	99/380 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1214 QQQAGAAG-----TAAGQPANKK-----IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGE 1268
            ||.:|..|     |||....|:|     ::|||||||::|:..|:.:.:::|...|..:||.||.
  Rat    15 QQASGGGGGGGNATAAATGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGA 79

  Fly  1269 WWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSST-----STATPGGKASGAAGTGD 1328
            .|..|...:|..:.:.|..::..|.|.||::|:  :.|||:.|     ....|||..:
  Rat    80 EWKLLSETEKRPFIDEAKRLRALHMKEHPDYKY--RPRRKTKTLMKKDKYTLPGGLLA------- 135

  Fly  1329 AKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKG 1393
                                  |||:....|.|:.:.| |..:...:|:|          ..|.|
  Rat   136 ----------------------PGGNSMASGVGVGAGL-GAGVNQRMDSY----------AHMNG 167

  Fly  1394 --NGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQ 1456
              ||:..:|:.:|...: ...|......|.|.:.:.|:...: .|......|   |....|..:.
  Rat   168 WSNGSYSMMQEQLGYPQ-HPGLNAHGAAQMQPMHRYDVSALQ-YNSMTSSQT---YMNGSPTYSM 227

  Fly  1457 RSAEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIG 1521
                .:|..|..|.|:       |.....:|.:|..:.||:.|        |.:::
  Rat   228 ----SYSQQGTPGMAL-------GSMGSVVKSEASSSPPVVTS--------SSHSR--------- 264

  Fly  1522 VTPFQPTGGAFKSMPISPKGSGGK-PEDAGSLQAHIKQEDIKQEPPSPYKLNNGS 1575
             .|.|  .|..:.| ||....|.: ||.|...:.|:.|.  .|..|.|....||:
  Rat   265 -APCQ--AGDLRDM-ISMYLPGAEVPEPAAPSRLHMAQH--YQSGPVPGTAINGT 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	25/75 (33%)
Sox2	NP_001102651.1	SOX-TCF_HMG-box	42..113	CDD:238684	24/72 (33%)
Sox2	NP_001102651.1	SOXp	112..202	CDD:403523	25/132 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910