DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Sox15

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	618	Identity:	130/618 - (21%)
Similarity:	205/618 - (33%)	Gaps:	179/618 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1221 GTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELA 1285
            ||.:......:|||||||||:::|..||.:..::|:..|..:||:||:.|.:|.|:.:..|.|.|
  Fly   204 GTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEA 268

  Fly  1286 SSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGK----ASGAAGTGDAKQR-------LVSVDGS 1339
            ..::..|...||.:|:..:.|::|......||||    :|...|||.:|..       |.:...|
  Fly   269 ERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKLATPPLATASSS 333

  Fly  1340 ----------DSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGN 1394
                      :|...:...|||||.       ....|:....|.::|.| |..|......|:..|
  Fly   334 YTTPTDESTCNSTNQNHGQSTPGGL-------YEQPLKPTYSPSSVDCY-SNADSTEQIESLAAN 390

  Fly  1395 GNGKLMKNELPS--DEDEQMLV----------VEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDY 1447
            ....|:....|:  ..|..:|:          ..:.:|::..|..:   :.:.:.|........|
  Fly   391 CPPALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSRQEKLAKSEE---KNKGSQSQGQSQQGIY 452

  Fly  1448 RKQQPEA----------------NQRSAEEHSTSGANGQAINA---PPLSGGEREITLKPK---- 1489
            ....|.|                |.|...:|      |.::..   ||:|..|.:.:...:
  Fly   453 AATYPLAPTSVAVVAARGMYVTCNNRGLLDH------GHSVKGTFYPPVSVSEDDNSTSMRNSIS 511

  Fly  1490 AIKAH-------PVLESNMLPYTQMSIYTQYTSPK--------NPIGVTPFQPTGGAFKSMPISP 1539
            |::.|       |......:|.::||.||...:..        |.:....:.|:..|:
  Fly   512 ALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCGNLRLSMNELSGNEYLPSANAY------- 569

  Fly  1540 KGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASGGGVVSAPPPNSG----SVGAIFNF 1600
               |.:.||....|::    |:.....:.......|.||||...:..|..|..    ...|..|.
  Fly   570 ---GMQYEDFLRYQSN----DMDYSTSAVEHKETTSDSASGQKCLKYPDTNQNYDDYEAEAYSNA 627

  Fly  1601 NVPTATALSQKQFHYPMHHPHRSPTDLRA-AHQACVP----------SSPAGMGLGHAANIATPP 1654
            .:|...|....|..||       ||.|.| ..|..||          :.|...|..|..|.....
  Fly   628 MLPATAASYYTQLPYP-------PTSLAAFPLQLAVPFQQTTSGAYGAQPIQSGYLHYGNYGGYE 685

  Fly  1655 ASAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQPGTPSLEHLQLDAFAPGGYTLRNHNGLSSLPP 1719
            ..|.:|.....|...:            |.||                             |.||
  Fly   686 GMAQSQPQNQAPVHHQ------------QASH-----------------------------SAPP 709

  Fly  1720 PVSAQPTMLL--------------HGYPPSHGV 1738
            .:|..|...:              |.:.|:.|:
  Fly   710 SLSVPPNQTVTSNSAAISMQQHHHHHFGPAPGM 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	28/70 (40%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	28/70 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I3058
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910