DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Sox17

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001101372.1	Gene:	Sox17 / 312936	RGDID:	1305371	Length:	423	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	109/492 - (22%)
Similarity:	178/492 - (36%)	Gaps:	145/492 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1201 SQSLSALQQQQQQQQ---QAGA-AGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRT 1261
            ::|||:|...:.:.:   .:|| |||::...|..:|||||||||:::|..||.:.:::|:..|..
  Rat    33 AESLSSLGDVKVKGEVVASSGAPAGTSSRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAE 97

  Fly  1262 VSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGT 1326
            :||:||:.|.||...:|..:.|.|..::..|.:.||.:|:  :.||:...
  Rat    98 LSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKY--RPRRRKQV--------------- 145

  Fly  1327 GDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTIS- 1390
                :|:..|:|  ...|.:.....|..|..||: ::.|..|  :|.....|.:    .|..:|
  Rat   146 ----KRMKRVEG--GFLHALAEPQAGALGPEGGR-VAMDGLG--LPFPEPGYPA----GPPLMSP 197

  Fly  1391 --------MKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDY 1447
                    .:|.|...|....||:.                                 |.:|.|.
  Rat   198 HMGAHYRDCQGLGAPALDGYPLPTP---------------------------------DTSPLDG 229

  Fly  1448 RKQQPEANQRSAEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQ 1512
            .:|.|                  |..|.||.|.      .|.|         ....|.|:|.|..
  Rat   230 VEQDP------------------AFFAAPLPGD------CPAA---------GAYTYAQVSDYAV 261

  Fly  1513 YTSPK-NPIGVTPFQPTGGAFKSMPISPK------GSGGKPEDAGSLQAHIK-QEDIKQEPPSP- 1568
            ...|. .|:.|.| .|:|.|...:...|.      |:.|.|..:.....|.: |:.::.:||.|
  Rat   262 PAEPSAGPMRVGP-DPSGSAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQPPPPP 325

  Fly  1569 -------YKLNNGSGSASGGGVVSAPPPNSGSVGAIFNFNVPTAT--ALSQKQFHYPMHHPHRSP 1624
                   ....:|.|..|       |||.:.........|.||..  .:.:.:|...:|..::..
  Rat   326 PPPPPPQQHPTHGPGQPS-------PPPEALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVYKPE 383

  Fly  1625 TDLRAAHQACVPSSPAGMGL----GHAANIATPPASA 1657
            ..|......|      |:.|    |..:::.:..:||
  Rat   384 MGLPYQGHDC------GVNLSDSHGAISSVVSDASSA 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	28/70 (40%)
Sox17	NP_001101372.1	SOX-TCF_HMG-box	67..138	CDD:238684	28/72 (39%)
Sox17	NP_001101372.1	Sox17_18_mid	203..253	CDD:403331	17/115 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000