DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Sox18

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001019952.1	Gene:	Sox18 / 311723	RGDID:	1311718	Length:	377	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	80/321 - (24%)
Similarity:	127/321 - (39%)	Gaps:	67/321 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1187 GAA----GAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAG--QPANK-KIRRPMNAFMIFSK 1244
            |||    |.|.|:.:.....|.|:|.:...:..::|..|...|  |.|:: :|||||||||:::|
  Rat    27 GAAAEPRGLPVTNVSPTSPASPSSLPRSPPRSPESGRYGFGRGERQTADELRIRRPMNAFMVWAK 91

  Fly  1245 KHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKS 1309
            ..||.:.:::|:..|..:||:||:.|..|...:|..:.|.|..::..|.:.||.:|:  :.|||.
  Rat    92 DERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKY--RPRRKK 154

  Fly  1310 S-------------------TSTATPGGKASGAA--------------GTGDAKQRLVSVDGSDS 1341
            .                   ::...|...|||:|              |.|........:||.:|
  Rat   155 QARKVRRLEPGLLLPGLVQPSAPPEPFAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLES 219

  Fly  1342 LEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDE----APTTISMKGNGNGKL--- 1399
            .|....| .|.....|..:...:....::.......|.|:..|    ||....:.|...|.|
  Rat   220 GEASFFP-PPLAPEDCALRAFRAPYAPELARDPSFCYGSSLAEALRTAPPAAPLAGLYYGTLGTP 283

  Fly  1400 --MKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDY----RKQQPEA 1454
              ..|.|....:...|    |..:|.....||.       :|:|.|.||.    .:.:|:|
  Rat   284 GPFPNPLSPPPEAPSL----EGTEQLEPTADLW-------ADVDLTEFDQYLNCSRTRPDA 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	27/70 (39%)
Sox18	NP_001019952.1	SOX-TCF_HMG-box	78..149	CDD:238684	27/72 (38%)
Sox18	NP_001019952.1	Sox17_18_mid	191..239	CDD:403331	9/48 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000