DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cic and Cic

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001359008.1	Gene:	Cic / 308435	RGDID:	1310706	Length:	2513	Species:	Rattus norvegicus

Alignment Length:	2722	Identity:	649/2722 - (23%)
Similarity:	928/2722 - (34%)	Gaps:	962/2722 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 STPQQQQPPQPRQHPKKRKFDPAELDKTEQHPQQ-QQQQQVSLQKQQKPAETTGNGDGLANGNQQ 170
            ||...:.||..|....:|: ...|.||.|:..:| |.|||...::.::..|.....|..|.|:..
  Rat    14 STSGSKSPPATRAKALRRR-GAGEGDKPEEEDEQAQPQQQTGPEEAEEGEEAEAERDPGAEGSHP 77

  Fly   171 HRMIVSCGAGAGNNSSNSSSSN----NSSHSSSDIKQQQQQRIIIASPQHASGSTYKQHVASGNN 231
            ........||...:......:.    :.|..::..|.:..::..:  .:|.:|.....
  Rat    78 ELQPNDLTAGLAEDPKGDGEAGRWEPSLSRKTATFKSRAPKKKYV--EEHGTGGLVGA------- 133

  Fly   232 SHAATINHQQRTHTPTTAVYYQQQQQQQQQQQQQRFSFNSNNQQHLQEQHQQ--------QQQQQ 288
                   .::|..||..|.......|.....:.......|.:...|:::..:        .....
  Rat   134 -------PEERERTPEDASALGVPPQPPTSTRSSSTDTASEHSADLEDEPPEACGPGPWPSAGTS 191

  Fly   289 SLLDLSEWNNTRVLAKIQNN-YAPGIIRHAQEASPDSILVEFDSTDLGLLLYTDVLHQGRNHVIL 352
            ...||.:..:.||||:..:. :.|.::|..:.:  ..:.|:|.. |..|..|..|...|.: |:|
  Rat   192 GGYDLRQLRSQRVLARRGDGLFLPAVVRQVRRS--QDLGVQFPG-DRALTFYEGVPGGGVD-VVL 252

  Fly   353 DASPPMADITLDARVCVRQRVEGRGSGSFVYVEGIITDINQATKQYSVQL--------------- 402
            ||:||...:.:...||.  .||   .|...|.||::.::......|.|:|
  Rat   253 DATPPPGALMVGTAVCT--CVE---PGVAAYREGVVVEVATKPAAYKVRLNPGPSSHAGSPGTLP 312

  Fly   403 -----IGDEMATTKVVRRADLRLLQPPWWDEL---------NELTTSGGASAP--ASSAKRKVP- 450
                 :..|......|.|:.||||:|||..|.         .|.....||:.|  :||.:.|.|
  Rat   313 QAQQPLHREPEEAIWVTRSSLRLLRPPWEPEALLRKHPAGPEEEQAEPGATLPPCSSSLEPKQPE 377

  Fly   451 -------AAGAGAGTGAAGCEAMTVPSGNIVYPKTATGAPLSFVATRYDGKLPTAPPTSSHQQAQ 508
                   :.|:..||   .||     .|...:| .|.|.|:         .||..||
  Rat   378 DAEVSNISFGSNLGT---HCE-----EGEERHP-PALGTPV---------LLPLPPP-------- 416

  Fly   509 QQLVKQEEYYRTTATSPFQTRPPLAGPSHGSEQVVQATQSHPQQYNGLADIVISPCSNGQHLKMQ 573
             ||:           ||....|...||...|||.                   |||
  Rat   417 -QLL-----------SPPPKSPAFGGPGRPSEQP-------------------SPC--------- 441

  Fly   574 QQQQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQRLTPRS 638
               |:.|:|                                      .||.|:.:.|::...|.:
  Rat   442 ---QEGSQG--------------------------------------GSRSSSVASLEKGAAPAA 465

  Fly   639 HPATPSAIHRSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCML--CTKESQRRGYCSRHLNQ 701
            ...||      ......::||||:|.:.:|:|||:|||||||||..  |.|||||||||||||:.
  Rat   466 RARTP------LTAAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSM 524

  Fly   702 KGNTSALPSSTGP---GRLLSDSRSSSKTQID--EDTSRDSETSPNYRVKG-------------R 748
            :.......:.:||   ||..:.:.....|:.|  ::||||||.| :...:|             |
  Rat   525 RTKEMEGLADSGPGGAGRPAAVAAREGSTEFDWGDETSRDSEAS-SVAARGDSRPRLVAPADLSR 588

  Fly   749 YDQEETDAAAMLVSLSSSRSATPSYT--------SPVNHAGASPLNAIAHSPVNVSATHRQNFFT 805
            ::.:|.:||.|||||.||||.|||::        ||......|||  ....|.|.|..:......
  Rat   589 FEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPL--FGFRPANFSPINASPVIQ 651

  Fly   806 PIANQSQQQQQQQP---VAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSN-------NNNNSNWE 860
            ..|.:|:......|   |..|.|  ....|.|......::|....|..:|       :......|
  Rat   652 RTAVRSRHLSASTPKAGVLTPPD--LGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTE 714

  Fly   861 VGSNSNTHVAATAAATSTVGAQPLPPQT----TPVSLVMHAPPPQQ-------QPLQQQHHHHQP 914
            :..:..|..|:.|...   ||.|..|::    :.|..|.|.|.|..       .|........||
  Rat   715 LLPHPGTLGASGAGGG---GAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQP 776

  Fly   915 PP----PPPASL---PAPSA----------------PPTSGSSSSHNSVGHATSVIRISSSQQQH 956
            .|    ||||.|   |.||.                |.....|.....||.|       ...:..
  Rat   777 SPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGAA-------GEARAG 834

  Fly   957 QQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLP---PTTVSFHQPNTPTSTAASVASMSQD 1018
            ...:..::...|..|.||..:..|          |||   |.||   .|..||:.|..:.::.
  Rat   835 GPGRGCRETPVPPGVASGKPSLPP----------PLPAPVPITV---PPAAPTAVAQPMPTLG-- 884

  Fly  1019 KMLAKNGYNAPWF-----KLLPHMTPMSKAS-PAPVTP-------TLTTSASSYNVVMMQQQQQH 1070
              ||.:.:....|     .|||.:.|.|..| |||...       |:.|:....:|.:.......
  Rat   885 --LASSPFQPVAFHPSPAALLPVLVPSSYPSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLV 947

  Fly  1071 QQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAAVANQRQK 1135
            ..|...|.....|.|..|.|.:|         |::|         |.:|  ..|.:||||:::..
  Rat   948 PFLAPSQPDPSVQPSEAQQPASH---------PVAS---------NQSK--EPAESAAVAHEQPP 992

  Fly  1136 ----------------QQQEEPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEECH 1184
                            .:...|...|   ......||.|.....:..|...|.......:.|..|
  Rat   993 GGTGGADPGRPPGATCPESPGPGPPL---TLGGVDPGKSLPPTTEEEAPGPPGEPRLDSETESDH 1054

  Fly  1185 DDGAAGAPATS------AAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKK----IRRPMNAF 1239
            ||......:..      ..|||:||||||.:::....:..      |:..||:    ||||||||
  Rat  1055 DDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKD------GRSPNKREKDHIRRPMNAF 1113

  Fly  1240 MIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSK 1304
            |||||:||.:||::||||||||||||||||||||.|::|.:||:||..||:||||.||:||||:|
  Rat  1114 MIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNK 1178

  Fly  1305 DRRKSSTSTATP------GG---------KASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGS 1354
            ||:||| |.|.|      ||         ..:|.|........|:|......|..|   :...||
  Rat  1179 DRKKSS-SEAKPASLGLAGGHKETRERSMSETGTAAAPGVSSELLSAAAQTLLSSD---TKAPGS 1239

  Fly  1355 GSCGGQ-------------------GISSDLQGDIIPLTIDNYNSTCD--------------EAP 1386
            |.||.:                   |:.|...|::....:........              .||
  Rat  1240 GPCGAERLHAVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPTSFSGPKPSPQYGAP 1304

  Fly  1387 TTISMKGNGNG------------------KLMKNELPSDEDEQMLVVEEEQQQQTV-------KK 1426
            .:.:..|.|..                  :....::.||| |:|::.|||.....:       ..
  Rat  1305 GSFAAPGEGGNLATSGRPPLLPSRASRSQRAASEDMTSDE-ERMVICEEEGDDDVIADDSFGTTD 1368

  Fly  1427 IDLHCRERVNDSDMDDTPFDYRKQQPEANQ-----------RSAEEHSTSGANGQAINAPPLSGG 1480
            |||.|:|||.||:..|:    ..:.||.|:           ||:..|.....:.:....|.
  Rat  1369 IDLKCKERVTDSESGDS----SGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPD---- 1425

  Fly  1481 EREITLKPKAI-KAH-PVLESNMLP-YTQMSIYTQYTSPKNPIGVTPF--QPTGGAFKSMPI--S 1538
                  .|.|. |.: |...|:..| .|.:|:.|.::     :|...|  |.:|....::|:  .
  Rat  1426 ------PPAAFSKGYGPTPSSSSSPASTSVSVSTSFS-----LGSGTFKTQESGQGSTAVPLRPP 1479

  Fly  1539 PKGSGG---------------------KPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGS----- 1577
            |.|:||                     :||..|||:|  ....:...|||      |.|:
  Rat  1480 PPGAGGPTTPSKATRFLPTDSATFRRKRPESVGSLEA--PGSSVIAAPPS------GGGNILQTL 1536

  Fly  1578 --------ASGGGVVSAPPPNSGSVGA------------IFNFNVP---TATALSQKQFHYPMHH 1619
                    ..|..|.|||.| |.:.||            :.|...|   |...::.|.|
  Rat  1537 VLPPSKEDREGTRVPSAPAP-SLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPF------ 1594

  Fly  1620 PHRSPTDLRAAHQ--------------ACVP-SSPAGMGLGHA---ANIATPPA----------- 1655
                ||..||...              :.|| .||.|:.|.::   :..||.||
  Rat  1595 ----PTSGRAEASSNDTVGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGT 1655

  Fly  1656 --SAPAQIMG--------GGPASQKM-FFAMTHPYTLLQRSH-----------------QPGT-- 1690
              .|||.:..        |.|||..: |.|...|.:......                 |||.
  Rat  1656 VGKAPATVTNLLVGTPGYGAPASPAVQFIAQGAPGSATPAGSGASAGSGPNGPVPLGILQPGALG 1720

  Fly  1691 ------------PSL-EHLQL----------DAFAPGG--------YTL---RNHNG-------- 1713
                        |:| :.||:          .|.||.|        :||   .:.||
  Rat  1721 KAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAP 1785

  Fly  1714 ------LSSLP--PPVSAQ---------------------------PTMLLHG------------ 1731
                  |.|:|  ||..||                           |:|.:.|
  Rat  1786 TAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSS 1850

  Fly  1732 ---YPPSHGVEPPAR----SPSYKSMPS----------------------TPKSA--TYLMSAPP 1765
               .|..:|.:.|::    :|...|.||                      .|.|.  ||:.||..
  Rat  1851 PFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGG 1915

  Fly  1766 ERGMDGGMSGC-----------ASAAASG-----------------GDESDIDADGQQFIL---- 1798
            .....|..|.|           ||:.|.|                 ..::.:.|.||..:.
  Rat  1916 HTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPS 1980

  Fly  1799 -----------------------APTPAQLGRAPLQRRKNLSQSKSESNV--------------- 1825
                                   |||.|.|| .|.|...:|..:.:.|..
  Rat  1981 PQLPPACTAPGGPVITAFYPGSPAPTSAPLG-PPSQAPPSLVYTVATSTTPPAAAILPKGPPASA 2044

  Fly  1826 ----------------SFGANLGASNGQHISRKLHSPTMMESSSPIIGHVNSSNLSSALPTPTSS 1874
                            |...:|.|...|..|.|.........:|..:|...|.......|||..|
  Rat  2045 TATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFESGTTGRTGPTPRQS 2109

  Fly  1875 --------TTTPNSD-------------------------------EQLPLT--PTTS----SSN 1894
                    ...|.|:                               |:.|.|  |.|:    ||:
  Rat  2110 LDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSS 2174

  Fly  1895 SNL--------NQQQPKSPMKGAP---------------GSTAAA-------------------- 1916
            |:.        ::.:|.:|...||               ||:..|
  Rat  2175 SDWRVPGLGLESRGEPPTPPSPAPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKKMKVR 2239

  Fly  1917 ---LKKKNDEMNNSVLKQVDFEKKYKALPQFQPED-CQSPSAIAVPSSPRVYGTNYRKKNTAPPP 1977
               |||..|.::|.||.:||||:::..||:|:||: ..||:..::.:|||....:||||
  Rat  2240 PPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKK------ 2298

  Fly  1978 VQKLMCEDDSIDEPASAPPTTTQRFFGPDFNNELKDERLAELESS----DQTGRSPRT------- 2031
             :|...:.||..|..::|....:|  ....::|....:.|:.|..    |:||.....
  Rat  2299 -RKNSTDLDSAPEDPTSPKRKMRR--RSSCSSEPNTPKSAKCEGDIFTFDRTGTETEDVLGELEY 2360

  Fly  2032 PKTPLQSARSDASEKGHRKVLETRRSLVLQLFAEHGNFPTAQATMAFQSKHSDVFPRKQDLQLKI 2096
            .|.|..|.         |:.|:.||:||:|||.:||.||:||||.|||::::|:||.|..|||||
  Rat  2361 EKVPYSSL---------RRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKI 2416

  Fly  2097 REVRQKLL----------------------GQASC---TPHSAGPNTPSDSNSSSTT 2128
            ||||||::                      |.|:.   ||..||...|:...|.|.|
  Rat  2417 REVRQKIMQAATPTEQPPGAEASLPGPPPTGMAATPVPTPSPAGGPDPTSPGSDSGT 2473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708	28/110 (25%)
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	53/74 (72%)
Cic	NP_001359008.1	DUF4819	252..346	CDD:374357	27/98 (28%)
		PHA03247	<749..1060	CDD:223021	78/357 (22%)
		NHP6B	<1077..1221	CDD:227935	77/150 (51%)
		SOX-TCF_HMG-box	1105..1176	CDD:238684	53/70 (76%)
		PRK07003	<1552..>1694	CDD:235906	36/152 (24%)
		PHA03247	<1638..2180	CDD:223021	95/542 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342353
Domainoid	1	1.000	171	1.000	Domainoid score	I3646
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10281at33208
OrthoFinder	1	1.000	-	-		FOG0007200
OrthoInspector	1	1.000	-	-		oto96374
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13059
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4626
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090