DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and sox17

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_571362.2	Gene:	sox17 / 30544	ZFINID:	ZDB-GENE-991213-1	Length:	413	Species:	Danio rerio

Alignment Length:	421	Identity:	98/421 - (23%)
Similarity:	159/421 - (37%)	Gaps:	82/421 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1204 LSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGE 1268
            ||.|...:.:.::..|||...|: :..:|||||||||:::|..||.:.:::|:..|..:||:||:
Zfish    36 LSPLSDSKSKHEKCSAAGPGRGK-SEPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGK 99

  Fly  1269 WWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGTGDAKQRL 1333
            .|.||....|..:.|.|..::..|.:.||.:|:  :.||:...........:....|..|||..|
Zfish   100 SWKALPMVDKRPFVEEAERLRVKHMQDHPNYKY--RPRRRKQVKRNKRLEPSFPLPGMCDAKMTL 162

  Fly  1334 VSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYN-STCDEAP----TTISMKG 1393
                         |  |.|.|....|.|:....:...:   .::|: .|.|.:|    ||...
Zfish   163 -------------C--TEGMSAGYSGAGLPQYCENHTL---FESYSLPTPDPSPMDAGTTEFF-- 207

  Fly  1394 NGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRS 1458
               .:|......|...:|    |...|:||....|.||.....                  ..:|
Zfish   208 ---AQLQDQSAFSYHHQQ----EHHFQEQTNILNDTHCHGNTQ------------------TLKS 247

  Fly  1459 AEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPY------TQMSIYTQYTSPK 1517
            .:.||.:.:|   ||....|.....|..:..:|....|...|..|.      |.::|:.:..|..
Zfish   248 RQSHSIAYSN---INTNTNSNLHAPINAQLSSINLQQVFHENANPQISHHPGTHLNIFNRSPSSS 309

  Fly  1518 NPIGVTPFQPTGGAFKSMPIS----PKGSGGKPEDAGSLQAHI-KQEDIKQEPPSPYKLNNGSGS 1577
            :...:||      |:.:.|.:    ...|....|.:..:.:|. ||:.|.:.........:.||.
Zfish   310 SHHAMTP------AYLNCPSTLDTFYNSSSQMKELSHCVSSHTHKQQSIAEAQSQASTATHSSGQ 368

  Fly  1578 ---------ASGGGVVSAPPPNSGSVGAIFN 1599
                     ....||.|||.|.|..:..:.:
Zfish   369 MVDEVEFEHCLSFGVPSAPLPGSDLISTVLS 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	28/70 (40%)
sox17	NP_571362.2	SOX-TCF_HMG-box	62..133	CDD:238684	28/72 (39%)
sox17	NP_571362.2	Sox_C_TAD	186..411	CDD:288887	50/250 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910