DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Sox7

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001099515.1	Gene:	Sox7 / 290317	RGDID:	1310038	Length:	383	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	102/472 - (21%)
Similarity:	149/472 - (31%)	Gaps:	189/472 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1218 GAAGTAAGQPANKK-----IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQ 1277
            |.:..|..:|:..|     |||||||||:::|..||.:..::|:..|..:||:||:.|.||...|
  Rat    26 GLSPPAVPRPSGDKGSESRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQ 90

  Fly  1278 KAQYHELASSVKDAHFKLHPEWKWCSKDRRK-------------------SSTSTATPGGKASGA 1323
            |..|.:.|..::..|.:.:|.:|:  :.|||                   |......|...:.|.
  Rat    91 KRPYVDEAERLRLQHMQDYPNYKY--RPRRKKQGKRLCKRVDPGFLLSSLSRDQNTLPEKNSIGR 153

  Fly  1324 AGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTT 1388
            ...|:.:.|.....|          :|..|..||..:|.::      .|.::|.|..   ..||.
  Rat   154 GPLGEKEDRGEYAPG----------ATLPGLHSCYREGAAA------APGSVDTYPY---GLPTP 199

  Fly  1389 ISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPE 1453
            ..|.            |.|      .:|.||                       |.|....|
  Rat   200 PEMS------------PLD------ALEPEQ-----------------------TFFSSSCQ--- 220

  Fly  1454 ANQRSAEEHSTSGANGQAINAPPLSGGEREITLKPKAIK-AHPV--LESNMLPYTQMSIYTQYTS 1515
                  |||      |...:.|.|.|........|..:. :||:  |.....|...|
  Rat   221 ------EEH------GHPHHLPHLPGPPYSPEFTPSPLHCSHPLGSLALGQSPGVSM-------- 265

  Fly  1516 PKNPIGVTPFQPTGGAFKS----MPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSG 1576
                :...|..|...|:.|    .|:.|           :||||:
  Rat   266 ----MSSVPGCPPSPAYYSHATYHPLHP-----------NLQAHL-------------------- 295

  Fly  1577 SASGGGVVSAPPPNSGSVGAIFNFNVPTATALSQ---------KQFHYPMHHPHRSPTDLRAAHQ 1632
                 |.:|.||.:.|         ..|...|||         .:|...::.|         .|
  Rat   296 -----GQLSPPPEHPG---------FDTLDQLSQVELLGDMDRNEFDQYLNTP---------GH- 336

  Fly  1633 ACVPSSPAGMG--LGHA 1647
               |.|.:|:|  .|||
  Rat   337 ---PDSASGVGTLTGHA 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	29/75 (39%)
Sox7	NP_001099515.1	SOX-TCF_HMG-box	44..115	CDD:238684	28/72 (39%)
Sox7	NP_001099515.1	Sox_C_TAD	178..381	CDD:288887	57/308 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000