DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Sox13

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	XP_006249824.1	Gene:	Sox13 / 289026	RGDID:	1309674	Length:	613	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	113/529 - (21%)
Similarity:	189/529 - (35%)	Gaps:	168/529 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   953 QQQHQ---QQQQHQQQAHPHVVVSGGQTFH---PVIVDATQLSVPLPPTTVS--------FHQPN 1003
            ||||:   .|||.||...|:|::....:.|   ||..| :||::|:.|....        .|.|.
  Rat   200 QQQHKINLLQQQIQQVNMPYVMIPAFPSSHQPLPVTPD-SQLALPIQPIPCKPVEYPLQLLHSPP 263

  Fly  1004 TPTSTAASVASMS--QDKMLAKNGYNAPWFKLLPHMT-----PMSKASPAPVTPTLTTSASSYNV 1061
            .|......||:..  |:.....|....|....||:.:     .|:...|.|         ||:..
  Rat   264 APVVKRPGVATHHPLQEPPQPLNLTAKPKVSELPNTSSSPSLKMNSCGPRP---------SSHGA 319

  Fly  1062 VMMQQQQQHQQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAA 1126
                            ..:..|.|||.:||.           ....|..:..::.||:....:.:
  Rat   320 ----------------PTRDLQSSPPNLPLG-----------FLGEGDAVTKAIQDARQLLHSHS 357

  Fly  1127 AAVANQRQKQQQEEPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNIRKLEE----CHDDG 1187
            .|:.|        .|......|:       ||.:|  ..|..||  ..:.:..|||    |..||
  Rat   358 GALEN--------SPSAPFRKDL-------ISLDS--SPAKERL--EENCVHPLEEAMLGCDVDG 403

  Fly  1188 AAGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHK 1252
                     ::..|:|.:                       :..|:|||||||:::|..|:.:.:
  Rat   404 ---------SRHFSESRN-----------------------SSHIKRPMNAFMVWAKDERRKILQ 436

  Fly  1253 KHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRR---------- 1307
            ..|:..|.::|||||..|.::..::|..|:|..:.:...|.:.:|::|:..:.:|
  Rat   437 AFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRPKRTCVVEGRRLR 501

  Fly  1308 ----KSSTSTATPGGKASGAAGTGDAKQRLVSVD-----------GSDSLEHDMCPSTPGGSGSC 1357
                |:...|...|.:.|.|. ...|.|..||.|           ....:||            .
  Rat   502 VGEYKALMRTRRQGARQSYAI-PPQAGQAQVSSDILFPRAAGMPLARPLVEH------------Y 553

  Fly  1358 GGQGISSDLQGDIIPLTIDNYNSTC---DEAPTTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQ 1419
            ..||:..::     |:.|    :||   :|...|.......:|::.:  ...|||.:   .:|:.
  Rat   554 DPQGLDPNM-----PVII----NTCSLREEGEGTDDRHSVADGEMYR--YSEDEDSE---GDEKS 604

  Fly  1420 QQQTVKKID 1428
            :::.|...|
  Rat   605 EEELVVLTD 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	24/70 (34%)
Sox13	XP_006249824.1	Herpes_UL46	<251..>419	CDD:355696	43/254 (17%)
Sox13	XP_006249824.1	SOX-TCF_HMG-box	415..486	CDD:238684	24/70 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000