DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Hbp1

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_037353.2	Gene:	Hbp1 / 27080	RGDID:	620444	Length:	523	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	113/583 - (19%)
Similarity:	189/583 - (32%)	Gaps:	190/583 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   852 NNNNNSNWEVGSNSNTHVA----------ATAAATS--------TVGAQP--------LPPQTTP 890
            :.::|..|||.:|...|..          ||..:.|        .|.:.|        :.....|
  Rat     6 SEHHNMVWEVKTNQRPHAVQRLLLVMDERATGVSDSLELLQCNENVPSSPGYNSCDEHMELDDLP 70

  Fly   891 VSLVMHAPPPQQQPLQ-QQHHHHQPPPPPPASLPAPSAPPTSGSSSSHNSVGHATSVIRISSSQQ 954
            ....:.:.|.|....| .....||..|.|..|......|.   ::...:.|...|.:..|::|.|
  Rat    71 ELQAVQSDPTQSAIYQLSSDVSHQEYPRPSWSQNTSDIPE---NTHREDEVDWLTELANIATSPQ 132

  Fly   955 QHQQQQQHQQQAHPHVVVSGGQTFH----PVIVDATQLSVPLP---------------------- 993
            ....|.....::.|..:::..::.|    |..|.:.:.....|
  Rat   133 SPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSAKSGPAFPHDHWKEETPVRHERANSESESG 197

  Fly   994 -------------------PTTV----------SFHQPN----TPTSTAASVASMSQD--KMLAK 1023
                               |:||          .||:.:    ......|..||..::  :|...
  Rat   198 IFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKESKKEWQDVEDFARAASCDEEEIQMGTH 262

  Fly  1024 NGYNAPWFKLLPHMTPMS--------KASPAPVTPTLTTSASSYNVVMMQQQQQHQQLQQQQQLQ 1080
            .||.:...|||.|...:|        ...|..|...|.|         ::.:..|
  Rat   263 KGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLT---------VECKLDH---------- 308

  Fly  1081 QQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAAVANQRQKQQQEEPDDQL 1145
                  |....|...:....|..:...|.|. |.::...|.....              .||...
  Rat   309 ------PFYVKNKGWSSFYPSLTVVQHGIPC-CEIHIGDVCLPPG--------------HPDAIN 352

  Fly  1146 DDD--VFET-----TTP-------GISANSKKQTAAMRLPTHNSNIRKLEECHDDG--------- 1187
            .||  ||:|     .||       .:|:.::::.|::             .|...|
  Rat   353 FDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASL-------------SCGGPGTGQEFAGSE 404

  Fly  1188 ---AAGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKM 1249
               :.|:|.:|.....|....|::..        ::||.:....| |.:|||||||:|:||:|..
  Rat   405 FSKSCGSPGSSQLSSSSLYTKAVKSH--------SSGTVSATSPN-KCKRPMNAFMLFAKKYRVE 460

  Fly  1250 VHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTS 1312
            ..:.:|.:|||.:|.|||:.|..:|.|::..|...|.::.:...:|:|:   |.|.:|.:|.|
  Rat   461 YTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPD---CWKRKRTNSGS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	27/70 (39%)
Hbp1	NP_037353.2	AXH	223..348	CDD:419838	25/164 (15%)
Hbp1	NP_037353.2	SOX-TCF_HMG-box	442..513	CDD:238684	28/73 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900