DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cic and CIC

DIOPT Version :9

Sequence 1:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster
Sequence 2:NP_001291744.1 Gene:CIC / 23152 HGNCID:14214 Length:2517 Species:Homo sapiens


Alignment Length:2716 Identity:640/2716 - (23%)
Similarity:909/2716 - (33%) Gaps:948/2716 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 QQPPQPRQHPKKRK-----FDPAELDKTEQHPQQQQQQQVSLQKQQKPAETTGNGDG-------- 163
            :.||..|....:|:     ..|.|.|...|.||.|...:.:.:.:::.||.....:|        
Human    19 KSPPATRAKALRRRGAGEGDKPEEEDDEAQQPQPQSGPEEAEEGEEEEAERGPGAEGPPLELHPG 83

  Fly   164 -LANGNQQHRMIVSCGAGAGNNSSNSSSSNNSSHSSSDIKQQQQQRIIIASPQHASGSTYKQHVA 227
             .|.|..:...    |.|.......|.|...::..|...|::..:       :|.:||:   .||
Human    84 DPAPGPAEDPK----GDGEAGRWEPSLSRKTATFKSRAPKKKYVE-------EHGAGSS---GVA 134

  Fly   228 SGNNSHAATINHQQRTHTPTTAVYYQQQQQQQQQQQQQRFSFNSNNQQHLQEQHQQ--------Q 284
            ..         .::|..||..|.......:.....:.......|.:...|:::..:        .
Human   135 GA---------PEERVRTPEEASGLGVPPRPPTSTRSSSTDTASEHSADLEDEPAEACGPGPWPP 190

  Fly   285 QQQQSLLDLSEWNNTRVLAKIQNN-YAPGIIRHAQEASPDSILVEFDSTDLGLLLYTDVLHQGRN 348
            .......||.:..:.||||:..:. :.|.::|..:.:  ..:.|:|.. |..|..|..|...|.:
Human   191 GSTSGSYDLRQLRSQRVLARRGDGLFLPAVVRQVRRS--QDLGVQFPG-DRALTFYEGVPGAGVD 252

  Fly   349 HVILDASPPMADITLDARVCVRQRVEGRGSGSFVYVEGIITDINQATKQYSVQL----------- 402
             |:|||:||...:.:...||.  .||   .|...|.||::.::......|.|:|           
Human   253 -VVLDATPPPGALVVGTAVCT--CVE---PGVAAYREGVVVEVATKPAAYKVRLSPGPSSQPGLP 311

  Fly   403 ---------IGDEMATTKVVRRADLRLLQPPWWDEL---------NELTTSGGASAPASSA--KR 447
                     :..|......|.|:.||||:|||..|.         .|.....||:.|...|  ..
Human   312 GSLPQPPQPLHREPEEAVWVARSSLRLLRPPWEPETMLRKPPTGPEEEQAEPGATLPPCPAALDP 376

  Fly   448 KVP--------AAGAGAGTGAAGCEAMTVPSGNIVYPKTATGAPLSFVATRYDGKLPTAPPTSSH 504
            |.|        :.|...||   .||     .|...:| .|.|.|         ..||..||    
Human   377 KQPEDAEVSKISFGGNLGT---HCE-----EGEEKHP-PALGTP---------ALLPLPPP---- 419

  Fly   505 QQAQQQLVKQEEYYRTTATSPFQTRPPLAGPSHGSEQVVQATQSHPQQYNGLADIVISPCSNGQH 569
                 ||:           ||....|...||....||.                   |||     
Human   420 -----QLL-----------SPPPKSPAFVGPGRPGEQP-------------------SPC----- 444

  Fly   570 LKMQQQQQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQRL 634
                   |:.|:|                                      .||.|:.:.|::..
Human   445 -------QEGSQG--------------------------------------GSRSSSVASLEKGT 464

  Fly   635 TPRSHPATPSAIHRSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCML--CTKESQRRGYCSR 697
            .|.:...||      ......::||||:|.:.||:|||:|||||||||..  |.|||||||||||
Human   465 APAARARTP------LTAAQQKYKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSR 523

  Fly   698 HLNQKGNTSALPSSTGP---GRLLSDSRSSSKTQID--EDTSRDSETSPNYRVKG---------- 747
            ||:.:.......:.:||   ||..:.:.....|:.|  ::||||||.| :...:|          
Human   524 HLSMRTKEMEGLADSGPGGAGRPAAVAAREGSTEFDWGDETSRDSEAS-SVAARGDSRPRLVAPA 587

  Fly   748 ---RYDQEETDAAAMLVSLSSSRSATPSYT--------SPVNHAGASPLNAIAHSPVNVSATHRQ 801
               |::.:|.:||.|||||.||||.|||::        ||......|||  ....|.|.|..:..
Human   588 DLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPL--FGFRPANFSPINAS 650

  Fly   802 NFFTPIANQSQQQQQQQP---VAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSNWEVGS 863
            ......|.:|:......|   |..|.|  ....|.|......::|....|..:|.........|.
Human   651 PVIQRTAVRSRHLSASTPKAGVLTPPD--LGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGR 713

  Fly   864 NSN---THVAATAA-ATSTVGAQPLPPQT----TPVSLVMHAPPPQQ-------QPLQQQHHHHQ 913
            ...   .|..|..| .....||.|..|::    :.|..|.|.|.|..       .|........|
Human   714 RKTELLPHPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQ 778

  Fly   914 PPP----PPPASL---PAPSA----------------PPTSGSSSSHNSVGHATSVIRISSSQQQ 955
            |.|    ||||.|   |.||.                |.....|.....||.|..|       :.
Human   779 PSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEV-------RA 836

  Fly   956 HQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLP---PTTVSFHQPNTPTSTAASVASMSQ 1017
            ....:..::...|..|.||.....|          |||   |.||   .|..||:.|..:.:.. 
Human   837 GGPGRGCRETPVPPGVASGKPGLPP----------PLPAPVPITV---PPAAPTAVAQPMPAFG- 887

  Fly  1018 DKMLAKNGYNAPWF-----KLLPHMTPMSKAS-PAPVTP-------TLTTSASSYNVVMMQQQQQ 1069
               ||.:.:....|     .|||.:.|.|..| |||...       |:.|:....:|.:......
Human   888 ---LASSPFQPVAFHPSPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSL 949

  Fly  1070 HQQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAAVANQRQ 1134
            ...|...|.....|.|..|.|.:|         |::|         |.:|  ..|.:||||::|.
Human   950 VPFLAPSQPDPSVQPSEAQQPASH---------PVAS---------NQSK--EPAESAAVAHERP 994

  Fly  1135 KQQQEEPDDQLDDDVFETTTP--------GISANSK-----KQTAAMRLPTHNSNIRKLEECHDD 1186
            .......|.:.........:|        |:..:.|     .:..|...|.......:.|..|||
Human   995 PGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDD 1059

  Fly  1187 GAAGAPATS------AAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKK----IRRPMNAFMI 1241
            ......:..      ..|||:||||||.:::....:..      |:..||:    ||||||||||
Human  1060 AFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKD------GRSPNKREKDHIRRPMNAFMI 1118

  Fly  1242 FSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDR 1306
            |||:||.:||::||||||||||||||||||||.|::|.:||:||..||:||||.||:||||:|||
Human  1119 FSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDR 1183

  Fly  1307 RKSS-----TSTATPGG---------KASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSC 1357
            :|||     ||....||         ..:|.|........|:||.....|..|   :...||.||
Human  1184 KKSSSEAKPTSLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSD---TKAPGSSSC 1245

  Fly  1358 GGQ-------------------GISSDLQGDIIPLTID----------NYN----STCDEAPTTI 1389
            |.:                   |:.|...|::....:.          :|:    ||...||...
Human  1246 GAERLHTVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPF 1310

  Fly  1390 SMKGNGNG------------------KLMKNELPSDEDEQMLVVEEEQQQQTV-------KKIDL 1429
            :..|.|..                  :....::.||| |:|::.|||.....:       ..|||
Human  1311 AAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDE-ERMVICEEEGDDDVIADDGFGTTDIDL 1374

  Fly  1430 HCRERVNDSDMDDT-----------------------------------------PFDYRKQQPE 1453
            .|:|||.||:..|:                                         |..:.|....
Human  1375 KCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGS 1439

  Fly  1454 ANQRSAEEHSTSGA-----------------NGQAINA------PPLSGGER------------E 1483
            |...||...::|.|                 :||...|      ||.:||..            .
Human  1440 APSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFLPMDP 1504

  Fly  1484 ITLK--------------PKAIKAHP-----VLESNMLPYTQ----------------------- 1506
            .|.:              |..|.|.|     :|::.:||..:                       
Human  1505 ATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAP 1569

  Fly  1507 --------MSIYTQYTSPKN----PIGVTPFQPTGGAFKSMPISPKGS-----------GGKPED 1548
                    .::.|....|.:    ||...|| ||.|..::.|....|:           ||.|..
Human  1570 AAPLSRPAATMVTNVVRPVSSTPVPIASKPF-PTSGRAEASPNDTAGARTEMGTGSRVPGGSPLG 1633

  Fly  1549 AGSLQAHIKQEDIKQEPP-------------SPYKLNN--------------------------- 1573
            ...:.:..|........|             :|..:.|                           
Human  1634 VSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGG 1698

  Fly  1574 ---GSGSASGGG------------------------------------VVSAPPPNSGSVGAI-- 1597
               |||:.:|.|                                    |..||.|..|:..|.  
Human  1699 TTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPS 1763

  Fly  1598 -------FNFNVPTATALSQK-------------------------QFHYPMHHPHRSPTDLRAA 1630
                   ..|.:|..|:.:.|                         |...|:..|....:.....
Human  1764 GPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLP 1828

  Fly  1631 HQACVP-SSPA----GMGLGHAANIATPPASAPAQIMGG-------------------------- 1664
            .:..|| ::|:    |.|.|....:.:||.|.|.|  .|                          
Human  1829 GKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQ--NGAQPPSKIIQLTPVPVSTPSGLVPPLS 1891

  Fly  1665 -----GPAS--QKMFFAMTHPYTLLQ-------------RSHQPGT------------------- 1690
                 ||.|  ||:....:...|.:|             .|.|.||                   
Human  1892 PATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGP 1956

  Fly  1691 -------PSLEHLQLDAFAPGGYTLRNHNGLSSLP----PPVSAQP-----TMLLHGYPPSHGVE 1739
                   |.|...|....|||      ..|:|.:|    ||..|.|     |....|.|......
Human  1957 SGPAFVQPLLSAGQAPLLAPG------QVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSA 2015

  Fly  1740 P---PARSPSYKSMPS---------TPKSATYLMSAP--PERGMDGGMSGCASAAASGGDESDID 1790
            |   |:::|     ||         ||.:||.|...|  |........|...||.|.....|.:.
Human  2016 PLAQPSQAP-----PSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVA 2075

  Fly  1791 ADGQQFILAPTPAQLGRAPLQRRKNLSQSKSESNVSFGANLGASNGQHISRKLHSPTMMESSSPI 1855
            ...|:    |:|    :||   :|..:...|....||.|......|....:.|....:.|.::| 
Human  2076 PKAQR----PSP----KAP---QKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAP- 2128

  Fly  1856 IGHVNSSNL----SSALPTPTSSTTTPNSDEQLPLTP------------------TTSSSNSNL- 1897
                 .|.|    :...|.|...|.||.:....||.|                  .:|||:..: 
Human  2129 -----ESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVP 2188

  Fly  1898 -----NQQQPKSPMKGAP-------GSTAAA---------------------------LKKKNDE 1923
                 |:.:|.:|...||       ||:.::                           |||..|.
Human  2189 GQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDS 2253

  Fly  1924 MNNSVLKQVDFEKKYKALPQFQPED-CQSPSAIAVPSSPRVYGTNYRKKNTAPPPVQKLMCEDDS 1987
            ::|.||.:||||:::..||:|:||: ..||:..::.:|||....:||||       :|...:.||
Human  2254 VDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKK-------RKNSTDLDS 2311

  Fly  1988 IDEPASAPPTTTQRFFGPDFNNELKDERLAELESS----DQTGRSPRT-------PKTPLQSARS 2041
            ..|..::|....:|  ....::|....:.|:.|..    |:||.....       .|.|..|.  
Human  2312 APEDPTSPKRKMRR--RSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSL-- 2372

  Fly  2042 DASEKGHRKVLETRRSLVLQLFAEHGNFPTAQATMAFQSKHSDVFPRKQDLQLKIREVRQKLL-- 2104
                   |:.|:.||:||:|||.:||.||:||||.|||::::|:||.|..|||||||||||::  
Human  2373 -------RRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQA 2430

  Fly  2105 --------------------GQASC---TPHSAGPNTPSDSNSSSTTLSAS 2132
                                |.|:.   ||..||...|:..:|.|.|..|:
Human  2431 ATPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAA 2481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cicNP_001262755.1 DUF4819 349..431 CDD:292708 28/110 (25%)
SOX-TCF_HMG-box 1231..1302 CDD:238684 53/74 (72%)
CICNP_001291744.1 DUF4819 252..349 CDD:406485 28/102 (27%)
dnaA 871..>1046 CDD:237605 43/201 (21%)
NHP6B <1080..1224 CDD:227935 76/149 (51%)
SOX-TCF_HMG-box 1108..1179 CDD:238684 53/70 (76%)
PHA03247 <1765..2185 CDD:223021 90/449 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148442
Domainoid 1 1.000 171 1.000 Domainoid score I3756
eggNOG 1 0.900 - - E1_KOG2746
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 305 1.000 Inparanoid score I2652
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10281at33208
OrthoFinder 1 1.000 - - FOG0007200
OrthoInspector 1 1.000 - - oto89251
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR13059
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3650
SonicParanoid 1 1.000 - - X4626
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.980

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