Protein Alignment cic and Sox5

DIOPT Version :9

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: XP_006506994.1
• Gene: Sox5 / 20678
• MGIID: 98367
• Length: 792
• Species: Mus musculus
• Alignment Length: 897
• Identity: 170/897 - (18%)
• Similarity: 274/897 - (30%)
• Gaps: 317/897 - (35%)

  Fly   753 ETDAAAMLVSLSSSRSATP-----------SYTSPVNHAGASPLNAIAHSPVNVSATHRQNFFTP 806
            |:..|.....:||.|.|:|           :....|....:..|.|. |.|::||..::.:
Mouse    32 ESKLALSRTEMSSKRPASPYGETDGEVAMVTSRQKVEEEESERLPAF-HLPLHVSFPNKPH---- 91

  Fly   807 IANQSQQQQQQQPVAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSN-----WEVGSNSN 866
                   .::.|||::............|.:|......|...||....|:|.     .|.|..|.
Mouse    92 -------SEEFQPVSLLTQETCGPRTPTVQHNTMEVDGNKVMSSLAPYNSSTSPQKAEEGGRQSG 149

  Fly   867 THVAATAAATSTVGAQPLPPQTTPVSLVMHAPPPQQQPLQQQHHHHQPPPPPPASLPAP------ 925
            ..|::.|..|         |:....||.......:|:.:::...:.....|....|.:.
Mouse   150 ESVSSAALGT---------PERRKGSLADVVDTLKQRKMEELIKNEPEDTPSIEKLLSKDWKDKL 205

  Fly   926 -----------SAPPTSGSSSSHNSVGHATSVIRIS---------------------------SS 952
                       ...|.|.:......:|....:..:.                           :.
Mouse   206 LAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAK 270

  Fly   953 QQQHQ---QQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLPPTTVSFHQPNTPTSTAASVAS 1014
            |||.|   ||||..||.|         ..:.:.....|:...|||..:....|:..|..||
Mouse   271 QQQEQIARQQQQLLQQQH---------KINLLQQQIQQVQGQLPPLMIPVFPPDQRTLAAA---- 322

  Fly  1015 MSQDKMLAKNG--YNAPWFKLLP-HMTPMSKASPAPVTPTLTTSASSYNVVMMQQQQQHQQLQQQ 1076
             :|...|...|  |.|......| .:.|.:.|:.|..||.|..        :..||....||...
Mouse   323 -AQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGP--------LQLQQFYAAQLAAM 378

  Fly  1077 Q------------------------QLQQQQQSPP-------QMPLNHNNNHLIVSAPLSSPGK- 1109
            |                        ...:...|||       ..|||      :.:.|.:|.||
Mouse   379 QVSPGGKLLGLPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLN------LSAKPKTSDGKS 437

  Fly  1110 -------------------PLNCSMNDAKVAAAAAAA-------------AVANQRQKQQQEEPD 1142
                               ||..|:..|..:.:|..:             |:...||.::|...:
Mouse   438 PASPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRRE 502

  Fly  1143 DQ-LDDDVFETTTPGIS-ANSKKQTAAMRLPTHNSNIRKLEE---CH----------DDGAAGAP 1192
            .| ||..|....:.|:| ..::|:...:...|....:::.||   .|          .||:||.
Mouse   503 QQALDGKVAVVNSIGLSNCRTEKEKTTLESLTQQLAVKQNEEGKFSHGMMDFNMSGDSDGSAGV- 566

  Fly  1193 ATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQ 1257
            :.|...|.|:                  |..:.:|   .|:|||||||:::|..|:.:.:..|:.
Mouse   567 SESRIYRESR------------------GRGSNEP---HIKRPMNAFMVWAKDERRKILQAFPDM 610

  Fly  1258 DNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASG 1322
            .|..:|||||..|.|:...:|..|:|..:.:...|.:.:|::|:  |.|.|
Mouse   611 HNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKY--KPRPK-------------- 659

  Fly  1323 AAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEA-- 1385
                     |...|||.                                .|.|..|.:.....
Mouse   660 ---------RTCLVDGK--------------------------------KLRIGEYKAIMRNRRQ 683

  Fly  1386 -----------------------PTTISMKGNGNGKLMKNELPSDE-------DEQMLVVEEEQQ 1420
                                   |:.|:|.|     :....|||:.       :..|.|:   |.
Mouse   684 EMRQYFNVGQQAQIPIATAGVVYPSAIAMAG-----MPSPHLPSEHSSVSSSPEPGMPVI---QS 740

  Fly  1421 QQTVKKIDLHCRERVNDSDMDD---TPFDYRKQQPEANQRS-AEEHSTSGAN 1468
            ....|..:.|.:|.:...|::.   ..:|..::.|:.:..| :|.|....||
Mouse   741 TYGAKGEEPHIKEEIQAEDINGEIYEEYDEEEEDPDVDYGSDSENHIAGQAN 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
		SOX-TCF_HMG-box	1231..1302	CDD:238684	25/70 (36%)
Sox5	XP_006506994.1	SOX-TCF_HMG-box	584..655	CDD:238684	25/72 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000