Protein Alignment cic and Sox12

DIOPT Version :10

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: NP_035568.1
• Gene: Sox12 / 20667
• MGIID: 98360
• Length: 314
• Species: Mus musculus
• Alignment Length: 248
• Identity: 54/248 - (21%)
• Similarity: 99/248 - (39%)
• Gaps: 64/248 - (25%)

  Fly  1218 GAAGTAAGQPA-----NKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQ 1277
            |.|...|.:|.     :..|:|||||||::|:..|:.:..:.|:..|..:||.||..|..|:..:
Mouse    21 GPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSE 85

  Fly  1278 KAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATP---------------------GGK-- 1319
            |..:...|..::..|...:|::|:..:.:.|.:.:.|.|                     ||:
Mouse    86 KIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRA 150

  Fly  1320 ASGAAGTG---------DAKQRLVSVDGSDSLEHDMCPSTPGGSGSCG----GQGISSDLQGDII 1371
            :.|..|.|         |.::.|:.|...::...::....|.|..:.|    .||.|.:
Mouse   151 SGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSGE------ 209

  Fly  1372 PLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTV 1424
                   .:....|..|:|          ::|.|.:|:|:....||.:::..|
Mouse   210 -------GAAASAASPTLS----------EDEEPEEEEEEAATAEEGEEETVV 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..432	CDD:465014
		HMG-box_CIC-like	1231..1308	CDD:438806	23/76 (30%)
Sox12	NP_035568.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		4/18 (22%)
		HMG-box_SoxC_SOX12	29..116	CDD:438847	24/86 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..287		29/168 (17%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269|PubMed:18403418	282..314