DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cic and gei-3

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001076772.1	Gene:	gei-3 / 184597	WormBaseID:	WBGene00001560	Length:	1405	Species:	Caenorhabditis elegans

Alignment Length:	2190	Identity:	477/2190 - (21%)
Similarity:	700/2190 - (31%)	Gaps:	918/2190 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 IAGIPTATTTAAAESTATQQHQQHQQQQQQQQHVLFQPHLQTTTATAATCSTPQQQQPPQPR--- 118
            ||.||:..|..:..|.|....:.|..:.|..                  .|.....|.|.|.
Worm    12 IAAIPSLLTQQSLPSAAATAFRSHTSESQDD------------------LSPTNSSQAPTPAGPI 58

  Fly   119 -QHPKKRKFDPAELDKTEQHPQQQQQQQVSLQKQQKPAETTGNGDGLANGNQQHRMIVSCGAGAG 182
             .......|:|..|            :.:::||...|
Worm    59 GAFRFSAFFNPDIL------------RNLNIQKSSPP---------------------------- 83

  Fly   183 NNSSNSSSSNNSSHSSSDIKQQQQQRIIIASPQHASGSTYKQHVASGNNSHAATINHQQRTHTPT 247
            |..|:......:|..|||...:.     :.||                   |||     |.|.|.
Worm    84 NQPSDDVPPPQTSQPSSDTTAEP-----LPSP-------------------AAT-----RIHHPI 119

  Fly   248 TAVYYQQQQQQQQQQQQQRFSFNSNNQQHLQEQHQQQQQQQSLLDLSEWNNTRVLAKIQNN-YAP 311
            ...|       .........|.|||                  :.|.:|...||||::... |.|
Worm   120 PVQY-------NTDLIAAATSVNSN------------------VILVDWLGHRVLARVPPGVYQP 159

  Fly   312 GIIRHA-------------QEASPDSILVEFDSTDLGLLLYTDVLHQGRNHVILDASPPMADITL 363
            |.::.|             :||..|.:..||:.|                .||.|.:|.::|:|.
Worm   160 GFVKTAYGNRDIIVQLDDGREARYDYVTSEFNLT----------------MVIADQAPSLSDLTT 208

  Fly   364 ---DARVCVRQRVEGRGSGSFVYVEGIITDINQATKQYSVQLIGDEMATTKVVRRADLRLLQPPW 425
               :..:.||..:|   ....:|....:...|....::.|::.....::  :|.||:||||:|||
Worm   209 LVSNTILAVRLPLE---KSETIYRTAELQSSNGNPPKFMVKVTNANYSS--LVSRANLRLLRPPW 268

  Fly   426 WDEL-NELTTSGGASAPASSAKRKVPAAGAGAGTGAAGCEAMTVPSGNIVYPKTATGAPLSFVAT 489
            :::| |....|.  |.|.||                     |::||                  |
Worm   269 YEDLINPQRVSN--SVPTSS---------------------MSLPS------------------T 292

  Fly   490 RYDGKLPTAPPTSSHQQA------QQQLVKQEEYYRTTATSPFQTRPPLAGPSHGSEQVVQATQS 548
            ..||:    ..|:|....      |||..:.::.......:|..|  |::     :.|:|  |.:
Worm   293 SEDGR----QNTNSQDNVTLLMALQQQQRRSQQLQHVINITPIPT--PIS-----TGQIV--THA 344

  Fly   549 HPQQYNGLADIVISPCSNGQHLKMQQQQQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSA 613
            .|.   |...:.:.|...|      ...|:||......|||:||..  ......:|:.....:|:
Worm   345 SPA---GTVIVPVLPLQPG------TSNQESSSKTVSIDSDEELPE--SSNQDQSGEPSPTTVSS 398

  Fly   614 CSKRSSMQSRGSTSSLLDQRL-TPRSHPATPSAIHRSQATT--------PHRFKKGDIVESESGV 669
            .:.||...:....|.:.:..: ||:|     |..|...|..        ..|||||:||.::.|:
Worm   399 AASRSLFVNPSQDSGIFEADVDTPQS-----SMFHSINAPVCATKAMLDQQRFKKGEIVTTQCGI 458

  Fly   670 RKKYNGKQWRRLCML--CTKESQRRGYCSRHLNQKGNTSALPSSTGPGRLLSDSRSSSKTQIDED 732
            |||:|||||||||..  |.|||||||||||||:.|   |..|......|   .|..|||:.|
Worm   459 RKKFNGKQWRRLCSKEGCNKESQRRGYCSRHLSLK---SKPPHGHHMER---GSPGSSKSDI--- 514

  Fly   733 TSRDSETSPNYRVKGRYDQEETDAAAMLVSLSSSRSATPSYTSPVNHAGASPLNAIA------HS 791
                            :..|.|   ..|.|.::||..|...|: |.....:||:|..      :.
Worm   515 ----------------FHPEPT---VFLPSSTASRVPTTVNTA-VFSGKINPLSAPTSLLTDKNL 559

  Fly   792 PVNVSATHRQNF--FTPIAN----QSQQQQQQQPVAVPLDSKWKTTPSPVLYNANN----NSSNN 846
            ||.:.|....|.  ...:.|    ..||.||.....||...:.:.|   .:..||:    ..|..
Worm   560 PVQLVAERAHNLQQILQLGNVRFDNFQQIQQLLMQHVPQGRRHEPT---AVSQANSAFCPPISLP 621

  Fly   847 NTSSSNNNNNSNWEVGSNSNTHVAATAAATSTVGAQPLPPQTTPVSLVMHAPPPQQQPLQQQHHH 911
            ||||..|.|.:                          |..|.|......||....||.:..|:..
Worm   622 NTSSMFNINPA--------------------------LFSQLTAPLFQQHAQAILQQQINAQNSQ 660

  Fly   912 HQPPPPPPASLPAPSAPPTSGSSSSHNSVGHATSVIRISSSQQQHQQQQQHQQQAHPHVVVSGGQ 976
            .......||. ..|......|:.|.:           :|..|:..::.......:      |||
Worm   661 TNNNSLKPAE-DEPEEEDDDGAGSDN-----------VSVCQKTEERSDDDDDDS------SGG- 706

  Fly   977 TFHPVIVDATQLSVPLPPTTVSFHQPNTPTSTAASVASMSQDKMLAKNGYNAPWFKLLPHMTPMS 1041
                                     ....|||.:|..:.|...           |::  |.|  |
Worm   707 -------------------------GGGLTSTGSSNPNGSSSN-----------FQI--HTT--S 731

  Fly  1042 KASPAPVTPTLTTSASSYNVVMMQQQQQHQQ----------LQQQQQLQQQQQSPPQMPLNHNNN 1096
            ::..:.|||   ||....|    |.||.:.:          :.|:..::.....||.:|
Worm   732 RSGESNVTP---TSGGDQN----QNQQSNSRNSSAELAGCDMSQELSVETSDAGPPTLP------ 783

  Fly  1097 HLIVSAPLSSPGKPLNCSM-NDAKVAAAAAAAAVANQRQKQQQEEPDDQLDD----DVFETTTPG 1156
                |.| ||.|..:|.:. :..|:                   ||:|..:.    ||.: ..|.
Worm   784 ----SQP-SSIGSSVNSAFRSPVKI-------------------EPNDDYEQSSVKDVMD-VKPE 823

  Fly  1157 ISANSKKQTAAMRLPTHNSNIRKLEECHDDGAAGAPATSAAKRRSQSLSALQQQQQQQQQAGAAG 1221
            :..::|:                                  :|||:
Worm   824 VFQSAKE----------------------------------RRRSK------------------- 835

  Fly  1222 TAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELAS 1286
            .:|.:|   .:||||||||||||:||.:||:::||:||||||||||||||:|..:|||:||:||:
Worm   836 VSANEP---HVRRPMNAFMIFSKRHRPLVHQQYPNKDNRTVSKILGEWWYSLAADQKAEYHKLAT 897

  Fly  1287 SVKDAHFKLHPEWKWCSKDRR-KSSTSTATPGGKASGAAGTGDAKQRLVS-------------VD 1337
            .||:||||.||:|||.:|::: ||.:...||       ......|.::..             ||
Worm   898 QVKEAHFKAHPDWKWSTKEKKIKSESLNTTP-------VALTPLKNKVFDFDIRTSDDLAKSFVD 955

  Fly  1338 GSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKN 1402
            |: :|...|.|.|||.|.
Worm   956 GT-ALLSPMTPMTPGASA----------------------------------------------- 972

  Fly  1403 ELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSAEEHSTSGA 1467
                                                        :|    ..:.|.:.:.|||..
Worm   973 --------------------------------------------FR----HLSSRDSTQSSTSSF 989

  Fly  1468 N--GQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVTP-FQPTG 1529
            :  |..:.:|.||.    |::...:|.:.|.|.|                      .|| ||
Worm   990 DFPGLPLMSPSLSA----ISMNTASITSSPALSS----------------------ATPSFQ--- 1025

  Fly  1530 GAFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSASGGGVVSAPPPNSGSV 1594
                                      ...|.:||            |:|   ||.  |..|...:
Worm  1026 --------------------------FDFESLKQ------------GTA---GVY--PTFNPAMI 1047

  Fly  1595 GAIFNFNVPTATALSQKQFHYPMHHPHRS----PTDLRAAHQACVPSSPAGMGLGHAANIATPPA 1655
            ..:.|.:.|....|       ||::...|    ||  .:|.:...|:..:.:|...:|:..|.|.
Worm  1048 STLVNSSTPCRQIL-------PMYNTDISSFFLPT--ASAFRVLNPTISSIIGGFSSADTVTTPL 1103

  Fly  1656 SAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQPGTPSL-----EHLQLDAFAPGGYTLRNHNGLS 1715
            .|||..|    |:.||.|              |.|.|:     |.|:..:|..   .::...|.:
Worm  1104 GAPATTM----AAMKMSF--------------PETASMLPQLQEKLESVSFLD---QIKIEPGET 1147

  Fly  1716 SLPPPVSAQPTMLLHGYPPSHGVEPPARSPSYKSMPSTPKSATYLMSAPPERGMDGGMSGCASAA 1780
            .||.|...:||::                          .:|.:|
Worm  1148 PLPSPNVVRPTII--------------------------PTAQFL-------------------- 1166

  Fly  1781 ASGGDESDIDADGQQFILAPTPAQLGRAPLQRRKN-LSQSKSESNVSFGANLGASNGQHISRKLH 1844
                      |..|||:|.|||||||   ::|.|. |.:..::..||
Worm  1167 ----------APTQQFVLQPTPAQLG---IRRNKRPLREIDTDVTVS------------------ 1200

  Fly  1845 SPTMMESSSPIIGHVNSSNLSSALPTPTSSTTTPNSDEQLPLTPTTSSSNSNLNQQQPKSPMKGA 1909

Worm  1201 ----------------------------------------------------------------- 1200

  Fly  1910 PGSTAAALKKKNDEMNNSVLKQVDFEKKYKALPQFQPEDCQSPSAIAVPSSPRVYGTNYRKKNTA 1974
                 |.|.|:|||..:.:|.:|.|.:|:..||:|.|:....     :|:||.:
Worm  1201 -----AKLFKRNDEQMDKLLARVGFTEKFAQLPEFTPKIYNE-----IPASPNL----------- 1244

  Fly  1975 PPPVQKLMCEDDSIDEPASAPPTTTQRFFGPDFNNELKDERLAELESSDQTGRSPRTPKTPLQSA 2039
            |.|. |...:|.||             |||.:||   .|::.  |...:.|.:|..||.||:.|.
Worm  1245 PTPF-KTPGQDQSI-------------FFGANFN---PDQQF--LSRDNVTPQSACTPMTPMMSG 1290

  Fly  2040 RSD---ASEKGHRKVLETRRSLVLQLFAEHGNFPTAQATMAFQSKHSDVFPRKQDLQLKIREVRQ 2101
            ::.   ......:|:||.||.||.....:.|.||.......||..|.:|||.:..|.||||||||
Worm  1291 QTTPMFGERSSIKKLLEERRRLVATFLDDQGLFPNNHTINEFQELHKEVFPTRNALILKIREVRQ 1355

  Fly  2102 KLLGQASCTPHSAGP-----------------NTPSDSNSSSTTL 2129
            :.:...|....|..|                 ..|:.|.||||.|
Worm  1356 RRMSTGSEAEPSYKPTIENIISALYDKYPHENKLPTSSFSSSTEL 1400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708	23/85 (27%)
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	50/70 (71%)
gei-3	NP_001076772.1	DUF4819	194..275	CDD:374357	23/85 (27%)
gei-3	NP_001076772.1	SOX-TCF_HMG-box	842..912	CDD:238684	49/69 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160171
Domainoid	1	1.000	121	1.000	Domainoid score	I3546
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10281at33208
OrthoFinder	1	1.000	-	-		FOG0007200
OrthoInspector	1	1.000	-	-		oto17830
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13059
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3650
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070