DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and sox-4

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001335567.1	Gene:	sox-4 / 182547	WormBaseID:	WBGene00015716	Length:	260	Species:	Caenorhabditis elegans

Alignment Length:	205	Identity:	41/205 - (20%)
Similarity:	91/205 - (44%)	Gaps:	37/205 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1153 TTPGISAN-------SKKQTAAMRLPTHNSNIRKLEECHDDGAAGAPATSAAKRRSQSL------ 1204
            |||..:|:       |....|..:|....:.::..|:.:|.....:|::..:...|.::
Worm    19 TTPIAAASSVSCPIVSPNMDATQKLLAIMATVKSFEQVNDSDGLSSPSSPESPTESPNVISSVQA 83

  Fly  1205 -------------SALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPN 1256
                         ::::......|::.:....|.:|   :|:|||||||::|::.|:.:......
Worm    84 STIADIIGHYVNGNSIKDVVNSSQKSASQPRTAREP---RIKRPMNAFMVWSQQRRQQIAATGQK 145

  Fly  1257 QDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKAS 1321
            ..|..:||:||..|..::..:|..:.|.|..:::.||..||::.:..:.|::..        |::
Worm   146 FHNSDISKMLGAEWRKMEEHEKVPFVERAKQLREEHFNAHPDYVYRPRRRKRVE--------KSA 202

  Fly  1322 GAAGTGDAKQ 1331
            |:..:..|.:
Worm   203 GSVDSNSADE 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	23/70 (33%)
sox-4	NP_001335567.1	SOX-TCF_HMG-box	120..191	CDD:238684	23/70 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910