DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and sem-2

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_740846.1	Gene:	sem-2 / 172162	WormBaseID:	WBGene00004771	Length:	404	Species:	Caenorhabditis elegans

Alignment Length:	478	Identity:	95/478 - (19%)
Similarity:	155/478 - (32%)	Gaps:	169/478 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1189 AGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAG----------------------QPANKK 1231
            |.|.:||.|...:.|.|....||.|..   ..|||||                      :.::..
Worm    31 AVASSTSGATNATSSNSVATSQQLQHH---PYGTAAGGYKHAQQAIPKSVTPYSDATNCKKSSNH 92

  Fly  1232 IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLH 1296
            |:|||||||::|:..|:.:.:..|:..|..:||.||..|.:|..|:||.:...|..::..|.:.:
Worm    93 IKRPMNAFMVWSQMERRKICEHQPDMHNAEISKQLGSRWRSLTDEEKAPFVAEAERLRVCHMQEY 157

  Fly  1297 PEWKWCSKDRRKSSTSTATPGGKASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQG 1361
            |::|:  |.|:|...:   |.|                      :|:.   |:.|
Worm   158 PDYKY--KPRKKPKKN---PDG----------------------TLQQ---PAQP---------- 182

  Fly  1362 ISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVK- 1425
                                  :||........|.....:.....:.|:|    .|.||.|..|
Worm   183 ----------------------QAPQQQQAPPRGASPQARQRKRPNTDQQ----SETQQFQNFKS 221

  Fly  1426 -KIDLHCRERVNDSDMDDTPF-----------------------DYRKQQPEANQRSAEEHSTSG 1466
             |::.......:.|.....||                       ||..||......:::.|:::|
Worm   222 VKVEQDWMGNAHMSHAQKMPFHPSYPSPSEFGHAPLTPESGFYDDYFTQQHHQQHFASQHHNSAG 286

  Fly  1467 AN------GQAINAPPLSGGERE----------ITLKPKAIKAHPV--LESNMLPYTQMSIYTQY 1513
            :.      |..:..||...|...          :...|.::....:  |.|....|...|...|.
Worm   287 SPLRMTNLGMDMGMPPQMMGHNSGFGAGNHPFYLHTSPPSVDQDDMRSLSSGSSGYADCSASEQS 351

  Fly  1514 TSPKNPIGVTPFQPTGGAFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSGSA 1578
            ||..|..||...                     ..|.:...|:  :|::|..|          :.
Worm   352 TSSPNSAGVVTM---------------------ATAATTTTHL--DDLEQICP----------TV 383

  Fly  1579 SGGGVVSAPPPNSGSVGAIFNFN 1601
            :.|.:|:.  |.|.::|...||:
Worm   384 TTGELVNY--PWSDALGIDINFS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	25/70 (36%)
sem-2	NP_740846.1	SOX-TCF_HMG-box	92..159	CDD:238684	23/66 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910