DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cic and SOX30

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_848511.1	Gene:	SOX30 / 11063	HGNCID:	30635	Length:	753	Species:	Homo sapiens

Alignment Length:	1081	Identity:	209/1081 - (19%)
Similarity:	322/1081 - (29%)	Gaps:	440/1081 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   898 PPPQQQPLQQQHHHHQPPPPP----------PASLPAPSAPPTSGSSSS--HNSVGHATSVIRIS 950
            ||||.:||       :|.|||          .|..|.||:|..|.::|:  .:|.|.|
Human     8 PPPQPRPL-------RPAPPPLPVEGTSFWAAAMEPPPSSPTLSAAASATLASSCGEA------- 58

  Fly   951 SSQQQHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLPPTTVSFHQPNTPTSTAASVASM 1015
                                |.||.|   |.:....|:.   |...:...||......||  ||.
Human    59 --------------------VASGLQ---PAVRRLLQVK---PEQVLLLPQPQAQNEEAA--ASS 95

  Fly  1016 SQDKMLAKNGYNAPWFKLLPHMTPMSKASPAPVTPTLTTSASSYNVVMMQQQQQHQQLQQQQQL- 1079
            :|.::|...    |..:||.             .||.:..|:|           ..:|...|.|
Human    96 AQARLLQFR----PDLRLLQ-------------PPTASDGATS-----------RPELHPVQPLA 132

  Fly  1080 ----QQQQQSPPQMPLNHNNNHLIVSAP-------LSSPGKPLNCSMNDAK------------VA 1121
                .::|:..|.:..:......:.:.|       |..||..|.....|.|            :.
Human   133 LHVKAKKQKLGPSLDQSVGPRGAVETGPRASRVVKLEGPGPALGYFRGDEKGKLEAEEVMRDSMQ 197

  Fly  1122 AAAAAAAVANQRQKQQQEEPDDQLDDDVF--ETTTPGISANSKKQTAAMRLPT------HNSNIR 1178
            ..|..:..|.:....:.|||:..|:|...  |..:.|:...|.:...|   ||      |..::|
Human   198 GGAGKSPAAIREGVIKTEEPERLLEDCRLGAEPASNGLVHGSAEVILA---PTSGAFGPHQQDLR 259

  Fly  1179 KLEECH--DDGA----AGAPATSAAKRRSQSLSALQQQQQQ------------------QQQAGA 1219
            .....|  ..||    .|||.:...:.....|:.:..:.|.                  ...||.
Human   260 IPLTLHTVPPGARIQFQGAPPSELIRLTKVPLTPVPTKMQSLLEPSVKIETKDVPLTVLPSDAGI 324

  Fly  1220 AGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHEL 1284
            ..|...:..|..::|||||||::::.||..:.|.:|..:|..:|..||..|..|..|||..|::.
Human   325 PDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDE 389

  Fly  1285 ASSVKDAHFKLHPEWKWCSKDRRKSSTSTATPGGKASGAAGTGDAKQRLVSVDGSDSLEHDMCPS 1349
            |..:|:.|.:..|.|.:..:           ||.:          |:..:||
Human   390 AQKIKEKHREEFPGWVYQPR-----------PGKR----------KRFPLSV------------- 420

  Fly  1350 TPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQMLV 1414
                              .::...|..|..||   .|||:
Human   421 ------------------SNVFSGTTQNIIST---NPTTV------------------------- 439

  Fly  1415 VEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQRSAEEHSTSGANGQAINAPPLSG 1479
                                          :.||...                  .::..|.|
Human   440 ------------------------------YPYRSPT------------------YSVVIPSL-- 454

  Fly  1480 GEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYTSPKNPIGVTPFQPTGGAF-------KSMPI 1537
             :..||        |||.|      |..:|.....:.::|..||.|||:..:.       .|:|:
Human   455 -QNPIT--------HPVGE------TSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPSLPV 504

  Fly  1538 SP-----KGSGGKPEDAGSLQAHIK-QEDIKQEPPSPYKLNNGSGSASGGGVVSA--------PP 1588
            .|     :.:|  |....:.|.|.: ...:||  |:|..|.:.:..:|......|        ||
Human   505 YPALPPQRFTG--PSQTDTHQLHSEATHTVKQ--PTPVSLESANRISSSASTAHARFATSTIQPP 565

  Fly  1589 PNSGSVGAIFNFNVPTATALSQKQFHYPMHHPHRSPTDLRAAHQACVPSSPAGMGLGHAANIATP 1653
            ....||..     .|.:..:.|..   |:.|||        .:|                   .|
Human   566 REYSSVSP-----CPRSAPIPQAS---PIPHPH--------VYQ-------------------PP 595

  Fly  1654 PASAPAQIMGGGPASQKMFFAMTHPYTLLQRSHQPGTPSLEHLQLDAFAPGGYTLRNHNGLSSLP 1718
            |...||.:.|..|.     |:..|||                     |.||.
Human   596 PLGHPATLFGTPPR-----FSFHHPY---------------------FLPGP------------- 621

  Fly  1719 PPVSAQPTMLLHGYPPSHGVEPPARSP-SYKSMPST-PKSATYLMSAPPERGMDGGMSGCASAAA 1781
                       |.:|.|  ..|.:|.| .|.:.||: |:..:|.....|:.
Human   622 -----------HYFPSS--TCPYSRPPFGYGNFPSSMPECLSYYEDRYPKH-------------- 659

  Fly  1782 SGGDESDIDADGQQFILAPTPAQLGRAPLQRRKNLSQSKSESNVSFGANLGASNGQHISRKLHSP 1846
             .|..|.::.|                 ...|...|:.....|.....|:   ||...... ||.
Human   660 -EGIFSTLNRD-----------------YSFRDYSSECTHSENSRSCENM---NGTSYYNS-HSH 702

  Fly  1847 TMMESSSPIIGHVNSSNLSSALPTPTSSTTTPNSDEQLPLT 1887
            :..|:.:| :..::...|.:....|||   ||:|.:|:.:|
Human   703 SGEENLNP-VPQLDIGTLENVFTAPTS---TPSSIQQVNVT 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	26/70 (37%)
SOX30	NP_848511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		15/43 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..161		2/23 (9%)
		SOX-TCF_HMG-box	336..406	CDD:238684	26/69 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..575		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..753		8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910