DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wun2 and PLPP2

DIOPT Version :9

Sequence 1:	NP_524991.1	Gene:	wun2 / 53558	FlyBaseID:	FBgn0041087	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_808211.1	Gene:	PLPP2 / 8612	HGNCID:	9230	Length:	309	Species:	Homo sapiens

Alignment Length:	238	Identity:	92/238 - (38%)
Similarity:	126/238 - (52%)	Gaps:	35/238 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LPMLGFSLWGEAVKRGFFCDDSSLRHPYRDSTMPSWILYLMCG-ALPLTVMLVV--EFFRGQDKR 164
            ||....:|.....||||:|.|.|:|:|||..|:...   ||.| .:..||:||.  |.:.....|
Human    41 LPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHG---LMAGVTITATVILVSAGEAYLVYTDR 102

  Fly   165 LHSPFPKSTMCSGYHLCHLELPTWLVECYHRMGIFIFGLGVEQLSTNIAKYSIGRLRPHFYTLCQ 229
            |:|              ..:...::...|..:|.|:||..|.|..|::|||.||||||:|..:|.
Human   103 LYS--------------RSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCD 153

  Fly   230 PVMKDGTTCSDPINAARYIE-EFTCAA--VDITSKQLKDMRLSFPSGHASFACYSMLYLVIYLHR 291
            |   |.:.    :|.:.|:: |..|..  .|:|     :.||||.|||:||..|.|::|.:|:..
Human   154 P---DWSR----VNCSVYVQLEKVCRGNPADVT-----EARLSFYSGHSSFGMYCMVFLALYVQA 206

  Fly   292 RMQWKQLRMLCHLLQFLLLMFAWYTALTRVSDYKHHWSDVLAG 334
            |:.||..|:|...:||.|:.||.|...||||||||||||||.|
Human   207 RLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVG 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wun2	NP_524991.1	PAP2_wunen	191..346	CDD:239479	66/147 (45%)
PLPP2	NP_808211.1	PAP2_wunen	115..261	CDD:239479	66/147 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144682
Domainoid	1	1.000	156	1.000	Domainoid score	I4177
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3741
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48083
OrthoDB	1	1.010	-	-		D434801at33208
OrthoFinder	1	1.000	-	-		FOG0000694
OrthoInspector	1	1.000	-	-		mtm8567
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10165
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X571
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870