DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wun2 and Plpp4

DIOPT Version :9

Sequence 1:	NP_524991.1	Gene:	wun2 / 53558	FlyBaseID:	FBgn0041087	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_001074432.1	Gene:	Plpp4 / 381925	MGIID:	2685936	Length:	271	Species:	Mus musculus

Alignment Length:	227	Identity:	64/227 - (28%)
Similarity:	93/227 - (40%)	Gaps:	64/227 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 RDSTMPSWILYLMCGALPLTVMLVVEFFRGQDKRLHSPFPKSTMCSGYHLCHLELPTWLVECYHR 195
            :...:|:.:::.:....||.|:.||:..|..||                       |.:.|.:..
Mouse    45 QSDNIPTRLMFAISFLTPLAVICVVKIIRRTDK-----------------------TEIKEAFLA 86

  Fly   196 MGIFIFGLGVEQLSTNIAKYSIGRLRPHFYTLCQP--VMKDGTTCS-DPINAARYIEEFTCAAVD 257
            :.:   .|.:..:.||..|..:||.||.|:..|.|  ||.....|: ||               |
Mouse    87 VSL---ALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVMNSEMRCTGDP---------------D 133

  Fly   258 ITSKQLKDMRLSFPSGHASFAC----YSMLYLVIYLH------RRMQWKQLRMLCHLLQFLLLMF 312
            :.|    :.|.||||.|:|||.    ::..||...||      |...|:    ||..:  |.|..
Mouse   134 LVS----EGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWR----LCAAI--LPLYC 188

  Fly   313 AWYTALTRVSDYKHHWSDVLAGSGIGLTYAVV 344
            |...||:|:.||||||.|...|..|||.:|.:
Mouse   189 AMMIALSRMCDYKHHWQDSFVGGVIGLIFAYI 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wun2	NP_524991.1	PAP2_wunen	191..346	CDD:239479	54/167 (32%)
Plpp4	NP_001074432.1	PAP2_containing_1_like	37..225	CDD:239484	64/227 (28%)
		Phosphatase sequence motif I. /evidence=ECO:0000250\|UniProtKB:Q5VZY2	102..110		3/7 (43%)
		Phosphatase sequence motif II. /evidence=ECO:0000250\|UniProtKB:Q5VZY2	143..146		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000250\|UniProtKB:Q5VZY2	195..205		6/9 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100228
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.670