DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and RGA2

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_010667.1	Gene:	RGA2 / 851985	SGDID:	S000002787	Length:	1009	Species:	Saccharomyces cerevisiae

Alignment Length:	504	Identity:	97/504 - (19%)
Similarity:	166/504 - (32%)	Gaps:	124/504 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   654 QKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQR--YIMREGKPYCLACFDTMFAE 716
            |...|..|::.|.|.:..|.|.:.||.:.|.|.:|:.:|....  .::..|...|..|.|.
Yeast     9 QSSLCVRCNKSIASSQVYELESKKWHDQCFTCYKCDKKLNADSDFLVLDIGTLICYDCSDK---- 69

  Fly   717 YCDYCGEVIGVDQGQMSHDGQHWHATDQCFSCCTCRCSLLGRPFL-PRRGTIYCSIACSKGEPPT 780
             |..||:.|  |...:.....:......||.||.|...:....:. .:||  .|.:.|
Yeast    70 -CTNCGDKI--DDTAIILPSSNEAYCSNCFRCCRCSNRIKNLKYAKTKRG--LCCMDC------- 122

  Fly   781 PSDTSSGPQLRPTHRASTSSQIAKSPRRGGERERDPGRKAHHGHPKATGSAGDLLERQERQRMEA 845
                                                       |.|.......|||.|.:.
Yeast   123 -------------------------------------------HEKLLRKKQLLLENQTKN---- 140

  Fly   846 AGVADLLLGGGVPGMPRPAHPPPIDLTELGISLDNICAGDKSI-FGDTQTLTNSMPDMLLSKADD 909
            :...|..:......:.||..|..|: .:..:|.:|.......: ..:.|.||   |.:|:|:..|
Yeast   141 SSKEDFPIKLPERSVKRPLSPTRIN-GKSDVSTNNTAISKNLVSSNEDQQLT---PQVLVSQERD 201

  Fly   910 SHSY-------QSIDK---------INLNSPSNSDLTQSTQELANELELDNEP-VRELPHD-GYE 956
            ..|.       .|.|:         ::::...||.|...:..:..:..:|||. :.::..| .|.
Yeast   202 ESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSLVDNEDYINKMGEDVTYR 266

  Fly   957 QLFANNRNQEHPAEQYDDEQLDNRPMKEVRFHSVQDTMSRSKSYTDNS------NARRRRRRRNQ 1015
            .|.....|::....:  |.::.|......||.|:.|.....|..|||.      |..|....:..
Yeast   267 LLKPQRANRDSIVVK--DPRIPNSNSNANRFFSIYDKEETDKDDTDNKENEIIVNTPRNSTDKIT 329

  Fly  1016 SRSSSEM--QIN------------------QTNLRLHNAQTQVGTTPLNLLNNLDNCDVASICST 1060
            |..:|.|  |:|                  :.|......||....: :|.::.:...|...:.::
Yeast   330 SPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKS-MNHVSPITRTDTVEMKTS 393

  Fly  1061 CSSSSSSDMDDYVYRLPARKHYGGVRVAYVPNDALAYERKKKMAQDSSL 1109
            .|||:....|:..:..|....      ..:|:..:|....||:::..||
Yeast   394 TSSSTLRLSDNGSFSRPQTAD------NLLPHKKVAPSPNKKLSRSFSL 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602
		LIM1_Prickle	593..651	CDD:188799
		LIM2_Prickle	656..711	CDD:188802	15/56 (27%)
		LIM3_Prickle	716..774	CDD:188804	13/58 (22%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780	14/53 (26%)
		LIM2_Rga	70..123	CDD:188781	14/106 (13%)
		RhoGAP	815..1002	CDD:214618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900