Protein Alignment esn and AJUBA

DIOPT Version :9

• Sequence 1: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Sequence 2: NP_116265.1
• Gene: AJUBA / 84962
• HGNCID: 20250
• Length: 538
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 117/531 - (22%)
• Similarity: 170/531 - (32%)
• Gaps: 165/531 - (31%)

  Fly   310 RFDGHSKRPPPP--AATAPKITQPSQVIEKFKPTPAPRSSGNMQQAPQQQQHPHPPSSSYYTQTE 372
            |::|.....|||  |...|:...|...:|...|..:||||
Human    84 RYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSS------------------------- 123

  Fly   373 SELLQIEAGGTGLTFASHSQRPESAISQVASTAHLDVPSAASSGSGGS-----AVSGGSGGAPES 432
                          |||.|....|..|....:..||  .|.:.|:|||     ..||.|.|..:.
Human   124 --------------FASSSASDASKPSSPRGSLLLD--GAGAGGAGGSRPCSNRTSGISMGYDQR 172

  Fly   433 AGRFVSPLQRRHC--QPPSHLPLNSVASPLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDD 495
            .|   |||....|  .||      ...:|   |.|......:.:...|:...:|..||.:    .
Human   173 HG---SPLPAGPCLFGPP------LAGAP---AGYSPGGVPSAYPELHAALDRLYAQRPA----G 221

  Fly   496 SGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPG-------------EKYRVKQLLHQLP 547
            .||....::: ||.|                    .|||             |:...:...|.:.
Human   222 FGCQESRHSY-PPAL--------------------GSPGALAGAGVGAAGPLERRGAQPGRHSVT 265

  Fly   548 PQDN---EVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERPCKGCEEPLSGGDIV--- 606
            ...:   ..||    .||....||:......|||..||..   |...| .|.|||  .|..|
Human   266 GYGDCAVGARY----QDELTALLRLTVGTGGREAGARGEP---SGIEP-SGLEEP--PGPFVPEA 320

  Fly   607 ------------------------VFAQRLGAQL---CWHPGCFVCSVCKELLVDLIYFQRDGNL 644
                                    ::.|....|.   .:|..||||..|...|....::..:|::
Human   321 ARARMREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSV 385

  Fly   645 YCGRHHA----ETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRYIMR-EGKP 704
            ||...:.    :....:|..|..:|. ::..:|.|:::|...|.|..|...|.|..:.:. ..:.
Human   386 YCEEDYLFSGFQEAAEKCCVCGHLIL-EKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQV 449

  Fly   705 YCLACFDTMFAEYCDYCGEVIGVDQG--------QMSHDGQHWHATDQCFSCCTCRCSLL---GR 758
            ||:..:...:|..|..||:.|...:|        .|..|   :|.  :|:.|..||..|.   |.
Human   450 YCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRD---YHF--ECYHCEDCRMQLSDEEGC 509

  Fly   759 PFLPRRGTIYC 769
            ...|..|.:.|
Human   510 CCFPLDGHLLC 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	21/111 (19%)
		LIM1_Prickle	593..651	CDD:188799	18/87 (21%)
		LIM2_Prickle	656..711	CDD:188802	13/55 (24%)
		LIM3_Prickle	716..774	CDD:188804	17/65 (26%)
AJUBA	NP_116265.1	PreLIM	1..335		74/338 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..172		31/128 (24%)
		PHA03418	<18..>103	CDD:177646	6/18 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	280..288		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..315		11/29 (38%)
		LIM1_Ajuba_like	338..391	CDD:188738	12/52 (23%)
		LIM2_Ajuba_like	403..455	CDD:188741	13/52 (25%)
		LIM3_Ajuba_like	463..524	CDD:188822	17/63 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810