Protein Alignment esn and prickle2a

DIOPT Version :10

• Sequence 1: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Sequence 2: XP_068079129.1
• Gene: prickle2a / 777736
• ZFINID: ZDB-GENE-061110-112
• Length: 870
• Species: Danio rerio
• Alignment Length: 906
• Identity: 310/906 - (34%)
• Similarity: 390/906 - (43%)
• Gaps: 306/906 - (33%)

  Fly   485 DFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQ 549
            ||||||.||||||||||||.||||||:|:||..|:...|:||||||||.|||:|:||||.||||.
Zfish    15 DFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYRFFPEDKVPYVNSIGEKHRIKQLLQQLPPH 79

  Fly   550 DNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERP-------CKGCEEPLSGGDIVV 607
            |||||||.||.:||::||:|||.||||:.||||.||.|    |       |:.|.|.:.||||.|
Zfish    80 DNEVRYCTSLDEEEKRELKIFSNQRKRDNLGRGTVRPL----PLTITGAICQQCGEQIKGGDIAV 140

  Fly   608 FAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTE 672
            ||.|:...|||||.||||.||.||||||||||.:|.:||||||||..||||||||||||:|||||
Zfish   141 FASRVAHGLCWHPHCFVCGVCSELLVDLIYFQLEGKIYCGRHHAERLKPRCSACDEIIFADECTE 205

  Fly   673 AEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQ 737
            |||:.||||||.|.|||..|||||||||||.|:|..||:.::|||||.|||.||:|||||:::||
Zfish   206 AEGQHWHMKHFCCYECEAPLGGQRYIMREGHPHCCNCFENLYAEYCDSCGEHIGIDQGQMTYEGQ 270

  Fly   738 HWHATDQCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPPTPSD------------------- 783
            |||||:.||||..|..|||||||||::|.||||..||:|:....||
Zfish   271 HWHATEDCFSCARCSQSLLGRPFLPKQGLIYCSRLCSQGDEAELSDSSDSAFQSARSRQSHHSAS 335

  Fly   784 ---------------TSSGPQL-----------------------RPTHRAST------------ 798
                           |||||..                       |..||..|
Zfish   336 VGKDGSKGKGETVRQTSSGPTTLSGDAEPLAVQMDLLSVASPAPSRTPHRTPTRTPSRTSSRSPS 400

  Fly   799 -----------------------------------------------------SSQIA--KSPRR 808
                                                                 |||.|  |.| .
Zfish   401 LNREQTVWVNRDEPYSYESQRDSSTSPNPHQLRSQCSIRTAYPPSPNQPPKIVSSQEAWSKEP-P 464

  Fly   809 GGERERDPGRKA-----------HHG-----HP---KATGSAGDLLERQERQRMEAAGVADLLLG 854
            ||..::.|...|           |||     ||   |...|..::..|.       :|..| ...
Zfish   465 GGNSKKPPVMAALRGHSFNENWMHHGQEPEFHPPKLKTQMSFNEVSSRN-------SGFLD-KRS 521

  Fly   855 GGVPGMPRPAHPP----------------PIDLTELG----ISLDNICAGDKSIFGDTQTLTN-- 897
            ..|.|.||...||                |::.|..|    ::|....||: |:.|.::...:
Zfish   522 ISVQGFPREMRPPLLRSRHQFRPNFGELTPLEQTPRGSADSLALSYTTAGN-SLDGTSRRQEHFS 585

  Fly   898 --SMPDMLLSKADDSHSYQSIDKINLNSPSNSDLTQSTQELANELELDNEPVRELPHDGYEQLFA 960
              ||||  |||....:..:......|||......|:|...:...|.....|||
Zfish   586 RFSMPD--LSKDSGVNVSEKGTVGTLNSSVQFRSTESLSSVPRPLADIGMPVR------------ 636

  Fly   961 NNRNQEHPAEQYDD-----------------------------EQLDNRPMKEVRFHSVQDTMSR 996
                ..:|...|.|                             :.:..||.:....:|.:....|
Zfish   637 ----LRYPPPLYWDSPRGLSFEDPVKGRIGLAGSMSCMQDGNAQAMTPRPRRAQAQNSPRQQRQR 697

  Fly   997 SKSYTDNSNARRRRRRRNQSRSSSEMQINQTNL--------RLHNAQTQVGTTPLNLLNNLDNC- 1052
            .:.:..|..:::.:.|..:|||.:.:.:...:.        |.||...:..::.|:  :||...
Zfish   698 QRHHRKNHKSQKYQYRSRRSRSDNALHLATEDQSFPGDPIHRFHNDFERPSSSRLS--HNLFGAN 760

  Fly  1053 ----------------------------------------DVASICSTCSSSSSSDMDDYVYRLP 1077
                                                    |....||||||||.:..||
Zfish   761 YGYRQQFFRPCPRTTSDLTLQDPGGPQIGQYMGRYGEAVEDEDQFCSTCSSSSEASDDD------ 819

  Fly  1078 ARKHYGGVRVAYVPNDALAYERKKKMAQDSSLAPGAGNASVGGAPAI----MHESKNCTIS 1134
                      ||:|.:.:....:.:...:..|........|||...:    ..:||||.||
Zfish   820 ----------AYLPGEGIPRPVQLRYFDNEELRHRYSPTLVGGHTQLHTRKRRKSKNCIIS 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	69/95 (73%)
		LIM1_Prickle	593..651	CDD:188799	38/57 (67%)
		LIM2_Prickle	656..711	CDD:188802	43/54 (80%)
		LIM3_Prickle	716..774	CDD:188804	40/57 (70%)
prickle2a	XP_068079129.1	PET_Prickle	22..118	CDD:193602	70/99 (71%)
		LIM1_Prickle	126..184	CDD:188799	38/57 (67%)
		LIM2_Prickle	189..244	CDD:188802	43/54 (80%)
		LIM3_Prickle	249..307	CDD:188804	40/57 (70%)