DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and Limch1

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	XP_036021493.1	Gene:	Limch1 / 77569	MGIID:	1924819	Length:	1511	Species:	Mus musculus

Alignment Length:	856	Identity:	150/856 - (17%)
Similarity:	268/856 - (31%)	Gaps:	313/856 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RLPQVGK-------QDQSRNYRDIVNLSECSSVLANTATTISDSSTTTAS------------SGS 56
            :|||.|:       |.:......:....|||..|....|.:||.:.:|:.            ..|
Mouse   733 QLPQDGREQNEEVIQKEHEMLPRVQRPEECSGPLYGPRTPVSDDAESTSMFDMRCEEEAAVLPHS 797

  Fly    57 PTRHRSCDSLSKSSQAEAGKLFPRNMPSIRR--SRRRAVSAERERLASRERLEEQVQPPKMPQIG 119
            ..|......::...:.|..|.    ...:.|  ||||:        ||::.::::.:..||.::.
Mouse   798 RARQEQLQLINNQLREEDDKW----QDDLARWKSRRRS--------ASQDLIKKEEERKKMEKLM 850

  Fly   120 AGQ------QSRLSTVTKLTPRKQSSKSTCSKHRGNA----PAKCIIKSAVRTKTKPKATTITLA 174
            :|:      :..:.|..::...|:..:....:...||    .|:.|::..:...|..:|....|.
Mouse   851 SGEDGTSERRKSIKTYREIVQEKERRERELHEAYKNARSQEEAEGILQQYIERFTISEAVLERLE 915

  Fly   175 PYEIALE-----------LPNESPAP----------------TLAMAVAQSSGCVQRKLSSEDQF 212
            ..:| ||           .||: |:|                |:...:|::        |..:..
Mouse   916 MPKI-LERSHSTEPNVSSFPND-PSPMKYLRQQSLPPPKFTATVETTIART--------SVPESI 970

  Fly   213 HSSGISCNGETDDDVEVAMLTGS----LTPSQIARIQGQQILRYDDLRNLNRCRNRNAVWLNPKD 273
            .|:|                |||    :||:.:..:..:.                   :..||:
Mouse   971 ASAG----------------TGSPSKIITPNTVPMLTPRP-------------------YSQPKN 1000

  Fly   274 TEQLLEVDKSRRKANCYFNQAIADDIQLSDIEEQLARFDGHSKRPPPPAATAPKITQ-------- 330
            ::::|:..|...|.:.....|..|:             :|..|..|..||..|.:|:
Mouse  1001 SQEVLKTFKVDGKVSMNGEMAPGDE-------------EGKEKEGPAAAAPGPSLTKSQMFEGVA 1052

  Fly   331 -----PSQV--------IEKFKPTPAPR--------SSGNMQQAPQQQQHP-----HPPSS--SY 367
                 |.||        |...||..||:        :..|.|:....::.|     .|.|:  .:
Mouse  1053 TVHDSPVQVKQGSNSIEINIKKPNSAPQELTAASEETESNGQEDEDGEERPGTGDLEPDSAEPQH 1117

  Fly   368 YTQT-------------------------------ESELLQIEAGGTGLTFASHSQRPESA---- 397
            :|.|                               |.|:    :|...|..:....:|:|.
Mouse  1118 FTTTVTRCSPTVALVEFSSNPQLKNEVPEQGQKKPEDEM----SGKVELVLSQKVAKPKSPEPEA 1178

  Fly   398 ------ISQVASTAHLDVPSAASSGSGGSAVSGGSGGAP-------------------------- 430
                  :.::..|..|.:|:.:|.....|: ....|..|
Mouse  1179 TLTFPFLDKMPETNQLHLPNPSSQADSPSS-EKSPGSTPFKFWAWDPEEERRRQEKWQQEQERLL 1242

  Fly   431 ---------------ESAGRFVSPLQRRHCQPPSHL------PL---NSVASPLRTASYKSAAAV 471
                           |.|.:.|...:||:.:....:      |.   :|.|..|.|    |.:..
Mouse  1243 QERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTISSSSADQLST----SLSVT 1303

  Fly   472 AGHGF------------HHSHHQQLDFQRNSQSDDDS------GCALEEYTWVP-PGLRPD-QVR 516
            .|.|.            .:...|:..||.|   |.||      |...||.:..| |...|: .|.
Mouse  1304 EGSGTRNKMDLENCPDKENERRQKTPFQEN---DGDSLLKTREGGLPEEQSLTPSPSANPEISVS 1365

  Fly   517 LYFSQLP----DDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYCHSLSDEERKELRIF---SAQR 574
            ....|.|    :...|:..:..:.       .|.||::.::....:.:.|:.|...:.   :...
Mouse  1366 KGIHQDPQLEAEAGAPHCGTNPQP-------AQDPPRNQQIPNPPTSTSEDVKPKTLALEKTINH 1423

  Fly   575 KREALGRGAVRLLSDERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQ 639
            :.|:.|... :.:|.::.|..|...|..|..::...   ..|.:|..||.|.:||..|.|.:...
Mouse  1424 QMESPGERR-KSISGKKLCSSCGLTLGKGAAMIIET---LNLYFHIQCFRCGICKGQLGDAVSGT 1484

  Fly   640 ----RDGNLYC 646
                |:|.|.|
Mouse  1485 DVRIRNGLLNC 1495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	20/110 (18%)
		LIM1_Prickle	593..651	CDD:188799	17/58 (29%)
		LIM2_Prickle	656..711	CDD:188802
		LIM3_Prickle	716..774	CDD:188804
Limch1	XP_036021493.1	CH_LIMCH1	23..140	CDD:409127
		DUF4757	250..>311	CDD:406382
		DUF4757	<739..872	CDD:406382	24/144 (17%)
		GBP_C	<1225..1262	CDD:419202	2/36 (6%)
		LIM	1441..1498	CDD:214528	17/58 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900