Protein Alignment esn and TRIP6

DIOPT Version :9

• Sequence 1: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Sequence 2: NP_003293.2
• Gene: TRIP6 / 7205
• HGNCID: 12311
• Length: 476
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 131/536 - (24%)
• Similarity: 179/536 - (33%)
• Gaps: 161/536 - (30%)

  Fly   318 PP--PPAATAPKITQPSQVIEKFKPTPAPRSSGNMQQAPQQQQHPHPPSSSYYTQTESE------ 374
            ||  |..|.||:    .:.|.:..|.|.|.....:|..|:....|.|....|......|
Human     8 PPKQPEPARAPQ----GRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAW 68

  Fly   375 -----LLQ----IEAGGTGLTFASHSQRPESAISQVASTAHLDVPSAASSGSGGSAVSGGSGGAP 430
                 :||    :.|...||       ||.|.      .|.:|:.|:..     :.::||.|.|.
Human    69 VGSHGVLQHTQGLPADRGGL-------RPGSL------DAEIDLLSSTL-----AELNGGRGHAS 115

  Fly   431 ESAGRFV-----SPLQRRHC---QPPSHLPLNSVASPLRTASYKSAAAVAGHGFH---------- 477
            ....|..     .|..|...   .|.|.||.:....| ..|||.:|:..||..|.
Human   116 RRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGP-TPASYTTASTPAGPAFPVQVKVAQPVR 179

  Fly   478 ----------------HSHHQQLDFQ-------RNSQSDDDSGCALEEYTWV--PPGL-----RP 512
                            ...|..|..:       ..||.:...| |.||...|  |.|.     ..
Human   180 GCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPG-AKEEAAGVSGPAGRGRGGEHG 243

  Fly   513 DQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQL--PPQDNEVRYCHSLSDEERKELRIFSAQRK 575
            .||.|  ||.|:|::..:        .|:|:|.:  ||..
Human   244 PQVPL--SQPPEDELDRL--------TKKLVHDMNHPPSG------------------------- 273

  Fly   576 REALGRGAVRLLSDERPCKGCEEPLSG-GDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQ 639
             |..|:           |.||.|.:.| |..||...|:     :|.||||||.|:..|....::.
Human   274 -EYFGQ-----------CGGCGEDVVGDGAGVVALDRV-----FHVGCFVCSTCRAQLRGQHFYA 321

  Fly   640 RDGNLYC-GRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRY-IMREG 702
            .:...|| |.:.|..:|  |:.|.:.|. |....|.|:.:|...|.|..|...|.|..: :....
Human   322 VERRAYCEGCYVATLEK--CATCSQPIL-DRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATS 383

  Fly   703 KPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHATDQCF--SCCTC-RCSLL------GR 758
            :.:|:..|...||..|..||..|..:.||  .:.....|.|:.|  .|..| .|.||      .:
Human   384 QIHCIEDFHRKFAPRCSVCGGAIMPEPGQ--EETVRIVALDRSFHIGCYKCEECGLLLSSEGECQ 446

  Fly   759 PFLPRRGTIYCSIACS 774
            ...|..|.|.|. |||
Human   447 GCYPLDGHILCK-ACS 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	21/104 (20%)
		LIM1_Prickle	593..651	CDD:188799	21/59 (36%)
		LIM2_Prickle	656..711	CDD:188802	13/55 (24%)
		LIM3_Prickle	716..774	CDD:188804	19/66 (29%)
TRIP6	NP_003293.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		23/95 (24%)
		Atrophin-1	<8..251	CDD:331285	61/268 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..253		35/148 (24%)
		LIM1_TRIP6	279..332	CDD:188736	21/57 (37%)
		LIM	339..398	CDD:295319	16/59 (27%)
		LIM3_Zyxin_like	399..461	CDD:188743	19/64 (30%)
		Interaction with MAGI1 and PTPN13. /evidence=ECO:0000269|PubMed:19017743	469..476

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810