Protein Alignment esn and Scel

DIOPT Version :10

• Sequence 1: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Sequence 2: NP_075024.2
• Gene: Scel / 64929
• MGIID: 1891228
• Length: 652
• Species: Mus musculus
• Alignment Length: 774
• Identity: 152/774 - (19%)
• Similarity: 239/774 - (30%)
• Gaps: 284/774 - (36%)

  Fly     2 LSKKRWWKIRLPQVGKQDQSRNY-RDIVNLSECSSVLANTATTISDSSTTTASSGSPTRHRSCDS 65
            |....|  |:.|.  :::|..|| |.::|                             ||.|.|:
Mouse    39 LQDNSW--IKKPP--EEEQDGNYGRVVLN-----------------------------RHNSHDA 70

  Fly    66 LSKSSQAEAGKLFPRNMPSIRRSRRRAVSAERERLASRERLEEQVQPPKMPQIGAGQQSRLST-- 128
            |.:       ||..|:.|....||.|:... .:|..|..|..:..:.|.:....|...:..||
Mouse    71 LDR-------KLIERDEPKATISRYRSEDM-LDRTLSSFRTPQSTKTPAVSSFNANTTATASTPA 127

  Fly   129 VTKLTPRKQS-----------SKSTCSKHRGNAPAKCIIKSAVRTKTKPKATTITLAPYEIALEL 182
            .|.:..::||           |.||.:..|..|                      |.|     .|
Mouse   128 TTPVKKKRQSWFPPPPPGHNASPSTAASRRDPA----------------------LHP-----PL 165

  Fly   183 PNESPAPTLAMAVAQSSGCVQRKLSSEDQFHSSGISCNGETDDDVEVAMLTGSLTPSQIARI--- 244
            |   |.|...:|..:..|...|      |.|::.....|||:...|..:.|..|  ..|.|:
Mouse   166 P---PKPCSPIASPKPLGRTNR------QIHAATAGACGETERHAERNIRTEDL--DDIIRVAAA 219

  Fly   245 -----QGQQILRYDDLRNLNRCRNRN------------AVWLNPK--DTEQLL----EVDKSRRK 286
                 :|:::   |:|..:|:..|||            |..|:.:  ..|.|:    :.|:. .|
Mouse   220 LQKTDKGEEL---DNLIRMNKSLNRNQGLDGLFRANLKAQQLDKRAQSLESLIYMNTQTDRD-GK 280

  Fly   287 ANCYF------NQAIADDIQLSDIE---------EQLAR----FDGHSKRPPPP----------- 321
            .|..|      ||....|.:..|:.         |::.|    .||..|..|..
Mouse   281 GNQAFGSLKKINQRADPDRRSQDLRSVIRTHATAERIGRRKQDLDGLIKVNPDTNKNMKRGKSLD 345

  Fly   322 --AATAPKITQ-----PSQVIEKF-KPTPAPRSSGNMQQAPQQQQHPHPPSSSYYTQTESELLQI 378
              ....|::.:     ||  ::.| |..|| ||..|.:...........||::..:|...:.|..
Mouse   346 NLIKVTPEVNRSNKGGPS--LDNFTKGVPA-RSRANQRDQDLDSLIKVTPSANRSSQHSLDELIN 407

  Fly   379 EAGGTGLTFASH----------------SQRPESAISQV---------ASTAHLD-----VPSAA 413
            .:..|..|.|.|                :||.....|.:         ..:..||     .|||.
Mouse   408 TSPQTIKTTARHQDLDKFIKVNPDVLTNNQRNHDVDSTIRGNPTGTRCEQSEELDNLIKVKPSAL 472

  Fly   414 SSGSGG---SAVSGGSGGAPESAGRFVSPLQRRHCQPPSHLPLNSVASPLRTASYKSAAAVAGHG 475
            .:.:||   .:::..:....|..||                 ::..|:.|..:.:|.:...:.:.
Mouse   473 RNTNGGQDLESLTEVNSHVAEKNGR-----------------IDGQANGLTNSLFKESTRASVYS 520

  Fly   476 FHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPGLRPDQV---RLYFSQLPDDKVPYVNSPGEKY 537
            :.         .|||.|.:...         ..|...|.|   |.|.......|..|..:...||
Mouse   521 YE---------ARNSLSSNSGN---------KNGGPKDTVVYTRTYVENSKSPKDGYQENISGKY 567

  Fly   538 RVKQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERPCKGCEEPLSG 602
                           ::..:|.||                       |.:.:...|..|.:|| |
Mouse   568 ---------------IQTVYSTSD-----------------------RSVIERDMCTYCRKPL-G 593

  Fly   603 GDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSAC 661
            .:..:....|  |:|.|..||.|.:||..|.:|   |...:::..|     |...|..|
Mouse   594 VETKMILDEL--QICCHSTCFKCEICKRPLENL---QAGDSIWIYR-----QTIHCEPC 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	14/98 (14%)
		LIM1_Prickle	593..651	CDD:188799	18/57 (32%)
		LIM2_Prickle	656..711	CDD:188802	2/6 (33%)
		LIM3_Prickle	716..774	CDD:188804
Scel	NP_075024.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..180		42/207 (20%)
		15 X approximate tandem repeats	207..496		58/297 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..385		9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..455		3/18 (17%)
		LIM	584..642	CDD:214528	20/68 (29%)