DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and prickle1b

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_001025269.1	Gene:	prickle1b / 556148	ZFINID:	ZDB-GENE-030131-2152	Length:	872	Species:	Danio rerio

Alignment Length:	897	Identity:	308/897 - (34%)
Similarity:	418/897 - (46%)	Gaps:	237/897 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 CQPPSHLPLNSVASPLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPG 509
            |..|..|...|...|:..|....:......|          |||:|.||||||||||||||||||
Zfish     6 CPHPMSLETTSGIWPITRAPDMDSRGAKAFG----------FQRSSTSDDDSGCALEEYTWVPPG 60

  Fly   510 LRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQR 574
            ||.:||::|||.||::|||||||||||:|::|||:||||.|||:|||.|||||||:||.:||.||
Zfish    61 LRAEQVQIYFSCLPEEKVPYVNSPGEKHRIRQLLYQLPPHDNEIRYCQSLSDEERRELHMFSMQR 125

  Fly   575 KREALGRGAVRLL--SDERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIY 637
            |:||||||..:||  :.:..|:.|:|.::||::.|||.|.|...||||.||.|..|.||||||||
Zfish   126 KKEALGRGTPKLLPRALQHNCEHCKENINGGEMAVFASRAGPGPCWHPACFTCYTCHELLVDLIY 190

  Fly   638 FQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRYIMREG 702
            |..:||::|||||||..||||||||||||:|||||||||.||||||:|.|||..||||||||::|
Zfish   191 FYHNGNIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFSCFECETILGGQRYIMKDG 255

  Fly   703 KPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHATDQCFSCCTCRCSLLGRPFLPRRGTI 767
            :|:|..||::::||||:.|||.||||..||:::|.||||||:||.|..|:.||||.||||:.|.|
Zfish   256 RPFCCGCFESLYAEYCEACGENIGVDHAQMTYEGVHWHATDKCFCCAQCKTSLLGCPFLPKDGRI 320

  Fly   768 YCSIACSKGEPPTPSDTSS-----------------GPQLRPTHRASTSSQIAKSPRRGGE---- 811
            |||..||.||....||:|.                 |...|||.:...:...:.:..|...
Zfish   321 YCSKDCSLGEDVQASDSSDSAFQSARSRESRRSIRMGKSSRPTEQCQQTKLYSATDYRTSSLCGD 385

  Fly   812 --------------------RERDP--------------------------GRKAHHGH------ 824
                                ||||.                          .|...|..
Zfish   386 NTETMCHQLERINFTEDNYWRERDEQEAPEDSVEDWAEHEDYMTQLLLKFGDRGVIHAEDSRAAE 450

  Fly   825 -------------PKATGSAGDLLERQERQRMEAA----GVADLLLG------------------ 854
                         |:...|..:|..::....|..|    |:.|...|
Zfish   451 PWMVKDTETNRTKPEIKMSGHNLASKKHHTDMYWAQSQDGLGDSAYGSHPGPASARKIQELEMDQ 515

  Fly   855 GGVPGM---PRPAHPPPIDLT---------ELGISLDNICAGD---KSIFGDT---QTLTNSMPD 901
            |.|||.   ||..:...::..         .:|.|:|::...:   .|:.||:   ||:.:
Zfish   516 GTVPGFWSEPRQWYEDSLECITSELRKADHNIGDSMDSLALSNITGASVDGDSKDRQTIYS---- 576

  Fly   902 MLLSKADDSHSYQSIDKIN----LNSP----SNSDLTQSTQELANELEL------DNEPVRELPH 952
             |.:..|.....:..|.|:    |||.    |.:.|.....||.:|..|      |:|..|..|:
Zfish   577 -LQNMKDQEREIEECDNISNVGTLNSSMLHRSANSLRSLNSELGHEETLGQGAREDDEEDRIPPY 640

  Fly   953 DGYE-------QLFANNRNQEHPAE-----QYDDEQLD----------NRPMKE----VRFHSVQ 991
            .|.|       .:....::|..|..     ::.|:.|:          ..||.|    ..||..:
Zfish   641 FGAEPPSPLNLPVLRRTKSQSQPQSRSQQVKFSDDVLEKGYYGALGLRQPPMSERTRRRTFHIEE 705

  Fly   992 DTMSRSKSYTDNSNARRRRRRRNQSRSSSEMQINQTNL-RLHNAQTQVGTT---PLN--LLNN-- 1048
            :..:.::....|.:..:||..| ::||.:.:.:...|. :||.....:.:.   |.|  |||:
Zfish   706 EAAAAAERRPANRHHHKRRHSR-KTRSENALHLPSKNRGKLHVVPQVISSNMPEPRNGILLNHSA 769

  Fly  1049 ------------------------LDNCD---VASICSTCSSSSSSDMDDYVYRLPARKHYGGVR 1086
                                    .|.||   ....|||||||||...::..:.        |..
Zfish   770 HSQHPYRQTTSDFPQQGMVRLDQFQDFCDDDEEDDWCSTCSSSSSESEEEGFFL--------GQP 826

  Fly  1087 VAYVPNDALAYERKKKMAQDSSLAPGAGNAS----VGGAPAIMHESKNCTIS 1134
            :....:.:..|..:....:.::|.|..|:.:    .|      |:.|||.||
Zfish   827 IPKPRSQSFHYYTEDYPTRVTALTPPFGSRTKLKKKG------HKGKNCIIS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	74/97 (76%)
		LIM1_Prickle	593..651	CDD:188799	33/57 (58%)
		LIM2_Prickle	656..711	CDD:188802	42/54 (78%)
		LIM3_Prickle	716..774	CDD:188804	36/57 (63%)
prickle1b	NP_001025269.1	PET_Prickle	43..139	CDD:193602	73/95 (77%)
		LIM1_Prickle	146..204	CDD:188799	33/57 (58%)
		LIM2_Prickle	209..264	CDD:188802	42/54 (78%)
		LIM3_Prickle	269..327	CDD:188804	36/57 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6711
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1235
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm6410
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830