DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and lmo7a

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	XP_021334325.1	Gene:	lmo7a / 553341	ZFINID:	ZDB-GENE-030219-74	Length:	1893	Species:	Danio rerio

Alignment Length:	1175	Identity:	217/1175 - (18%)
Similarity:	376/1175 - (32%)	Gaps:	373/1175 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PQVGKQDQSRNYRDIVNLSECSSVLANTATTISDSSTTTASSGSPTRHRSCDSLSKSSQAEAGKL 77
            |.:|::..:..|    |:|         |..:.|.......:.......|.|.|:|......  |
Zfish   587 PLLGREHPNDPY----NVS---------ADILPDLENDDMFTRRTNAFHSSDDLAKLKYGNF--L 636

  Fly    78 FPRNMPSIRRSRRRAV--------------SAERERLASRERLEEQVQ----------------- 111
            .||     |||.....              ..|::.:.|| ::::|:.
Zfish   637 VPR-----RRSEADVTVVIQPHHEGEPVYPDIEKDDVVSR-KVQQQISHRPLSGAPDNYHPVPIP 695

  Fly   112 -----PPKMPQIGAGQQSRLSTVTKLTPRKQSSKSTCSKHRGNAPAKCIIKSAVRTKTKP--KAT 169
                 |||:      |...:|..|:  ||:...|:....|............|:.|:...  ||.
Zfish   696 ETWALPPKL------QAKLMSDPTE--PRQSRPKAELKPHLKTDDMLLRKLRALNTQGTEGRKAA 752

  Fly   170 TITLAPYEIALELPNESPAPTLAMAVAQSSGCVQRK-LSSEDQFHSSGISCNGETDDDVEVAMLT 233
            .::|:..|..::         ...|:.::|....|| |..|..|         :.:.|.|.:...
Zfish   753 GVSLSCSEDDMQ---------KWQAIREASRVRYRKRLMVERLF---------QKNSDSEGSKSV 799

  Fly   234 GSLTPSQIARIQGQQILRYDDLRNLNRCRNRNAVWLNPKDTEQLLEVDKSRRKANCYFNQAIADD 298
            ..:|.|:::  .....||.::|:.:   |||      .|::|...:.|.||.|:.   .:::..|
Zfish   800 SDITESEMS--NSTMELRLEELQKM---RNR------LKESEDKWQDDLSRWKSK---RRSVNSD 850

  Fly   299 I-QLSDIEEQLARFDGHSKRPPPPAATAPKITQPSQVIEKFKPTPAPRSSGNMQQA--------- 353
            | :..:..||:.:.....             |:.|:..::.:.....|...|::.:
Zfish   851 IVKKKEEREQIEQITSVG-------------TRKSKTFKEMQDERESRGQSNLRDSFNSIVDDVF 902

  Fly   354 --PQQQQHPHPPSS----SYYTQTESELL---------QIEAGGTGLTFASH----SQRPESA-- 397
              |..:....||.|    :.||.|:...:         :..||    |.||.    |.:|..|
Zfish   903 EDPVPRSRTLPPRSYTIDTPYTATDKPFVPSIPSLREKEPVAG----TLASDQTDLSTKPARASP 963

  Fly   398 -----------ISQVASTAHLDVPSAASSGSGGSAVSGGSGGAPESAGRFVSPLQRRHCQPPSHL 451
                       :||..:.:.||.|..|.|.|..|.:...|...|.|:.:            |:..
Zfish   964 DIPDKINNSNQMSQTTTQSLLDDPVPAFSNSSTSLIKPASATKPTSSTK------------PNIS 1016

  Fly   452 PLNSVASPLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPGL--RPDQ 514
            ...|...|..::|...::.               ::.||.....||  |::.:...|.:  |.|.
Zfish  1017 EFISNTKPAESSSDAISSL---------------YKPNSMDTKPSG--LDQVSASLPKIYQRSDS 1064

  Fly   515 VRLYFSQLP-------------------DDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYCHSLS 560
            .||....:|                   ||.|...|  ||...:|:...|       .||...::
Zfish  1065 ARLTSVVMPRPFGTQSNRIASLPRAFTMDDSVKRTN--GESNSLKKTAVQ-------NRYAQYMT 1120

  Fly   561 DEER-KELRIFSAQRKREALGRGAVRLLSDERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFV 624
            ||:: ::....|::.:.....:..|..::...|......||:..:.|.:
Zfish  1121 DEDKSQQTPDHSSEEEEVERTQSPVPPVNRVSPLPKSTSPLNPPNEVGY---------------- 1169

  Fly   625 CSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECE 689
                .|:.:.|                 .|||..|.  :..|..:......|...:...:..|..
Zfish  1170 ----NEMRISL-----------------NQKPNSSR--DFGFQHDWDSTGVRVKSVAPGSPAEFG 1211

  Fly   690 HQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHD-----GQHWHATDQCFSCC 749
            ....|...:...|....    |..::|:.:...|.:  .||.:..|     ..:|
Zfish  1212 QVQAGDEILTVNGHRVA----DMSYSEWKNSMEEAL--QQGSLLMDIRRQGKNNW---------- 1260

  Fly   750 TCRCSLLGR--PFLPRRGTIYCSIACSKGEPPTPSDTSSGPQLRPTHRAS---TSSQ----IAKS 805
                   ||  |.||.:.  :.:|..:..:|..||:        |.|..|   ||.|    :.||
Zfish  1261 -------GRDLPSLPYKS--HKTINLTSLDPLGPSE--------PYHTTSLDFTSQQSKDAVVKS 1308

  Fly   806 PRRGGERERDPGRKAHHG---------HPKATGSAGDLLERQERQRMEAAG--VADL--LLGGGV 857
            .....:...:.|....:|         :.|.:.|..:|..|.|.....:||  |:.|  |.||.
Zfish  1309 VNVSSQPAYNHGSNGINGAFREDSESVNNKESISLKNLKRRSEFFEQGSAGLTVSSLVYLCGGS- 1372

  Fly   858 PGMPRPAHPPPIDLTELGISLDNICAG------DKSIFGDTQTLTNSMPDMLL--------SKAD 908
                    ..||    |.:.:.:|.|.      |.......|.......|.||        .|.|
Zfish  1373 --------ETPI----LNVPVPSITASTTRWSWDPEEERKRQEKWQKEQDRLLKEKYKKDQEKLD 1425

  Fly   909 D--SHSYQSIDKIN------LNSPSNSDLTQST--------QELANELELD----NEPVRELPHD 953
            :  ..:.|.::|.|      ||..|.|.:.|.|        .:|| ::|.|    .|.::.|..:
Zfish  1426 EEWKKAQQELNKENFKNDEELNRHSLSTIRQPTVSWEEQNASKLA-QIEEDKKKRQEEMQRLEEE 1489

  Fly   954 GYEQLFANNRNQEHPAEQYDDEQLDNRPMKEVRFHSVQDTMSRSKSYTDNSNARRRRRRRNQSRS 1018
            ..::.....|.||...:|.:.::|:....|       ::...|.|...:.......||||.:.:.
Zfish  1490 RRKREEEMLRLQEERRKQEEQQRLEEEKRK-------KEEEERKKQIEEKQRLEEERRRREEQQR 1547

  Fly  1019 SSEMQ 1023
            ..|::
Zfish  1548 LEELR 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	23/117 (20%)
		LIM1_Prickle	593..651	CDD:188799	5/57 (9%)
		LIM2_Prickle	656..711	CDD:188802	7/54 (13%)
		LIM3_Prickle	716..774	CDD:188804	12/64 (19%)
lmo7a	XP_021334325.1	CH	17..128	CDD:237981
		DUF4757	239..>311	CDD:318215
		DUF4757	733..881	CDD:318215	35/192 (18%)
		TOP2c	<809..1096	CDD:330395	64/344 (19%)
		PDZ	1184..1245	CDD:238080	8/68 (12%)
		Neuromodulin_N	<1396..1506	CDD:331332	24/110 (22%)
		LIM	1824..1882	CDD:259829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900