DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esn and FBLIM1

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_001019386.1	Gene:	FBLIM1 / 54751	HGNCID:	24686	Length:	374	Species:	Homo sapiens

Alignment Length:	199	Identity:	57/199 - (28%)
Similarity:	81/199 - (40%)	Gaps:	34/199 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 CSACDEIIFSDE-CTEAEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACF-DTMFAEYCDY 720
            |:.|.:.:...| ..||..|.:|.:.|.|:.|..||.||.:..::|:|.|..|: ||:  |.|..
Human   183 CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTL--ERCGK 245

  Fly   721 CGEVIGVDQGQMSHD----GQHWHATDQCFSCCTCRCSLLGRPF-LPRRGTIYC--------SIA 772
            ||||:      ..|.    ||.:|.:  ||:|.||...:....| |..:..:||        ...
Human   246 CGEVV------RDHIIRALGQAFHPS--CFTCVTCARCIGDESFALGSQNEVYCLDDFYRYEKGL 302

  Fly   773 CSKGEPPTPSDTSSGPQ--LRPTHRASTSSQIA--KSPRRGGERERDPGRKAHHGHPKATGSAGD 833
            |:.....|..|.|...:  |.|...|..|..:.  |...|.|     .|..||..:|...|..|.
Human   303 CTGWGAGTGRDPSRVKELSLSPGCWARVSCLLVYYKEYYRAG-----LGAVAHACNPSTLGGRGG 362

  Fly   834 LLER 837
            .:.|
Human   363 WITR 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602
		LIM1_Prickle	593..651	CDD:188799
		LIM2_Prickle	656..711	CDD:188802	18/54 (33%)
		LIM3_Prickle	716..774	CDD:188804	19/70 (27%)
FBLIM1	NP_001019386.1	Filamin-binding	1..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..176
		LIM	183..236	CDD:259829	17/52 (33%)
		LIM2_FBLP-1	243..295	CDD:188758	18/59 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810