DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and Prickle3

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_001277553.1	Gene:	Prickle3 / 54630	MGIID:	1859635	Length:	624	Species:	Mus musculus

Alignment Length:	698	Identity:	270/698 - (38%)
Similarity:	332/698 - (47%)	Gaps:	196/698 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 DFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQ 549
            ||||:|.||||||||.|||.||||||:|:||..:||.||:||||||||||||||:|||||||||.
Mouse    75 DFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPH 139

  Fly   550 DNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERP-------CKGCEEPLSGGDIVV 607
            |:|.:||.:|.:||:||||.||.|||||.|||..||:.    |       |:.|.:.:.||||.|
Mouse   140 DSEAQYCTALEEEEKKELRAFSQQRKRENLGRATVRIF----PVTITGAICEECGKQIGGGDIAV 200

  Fly   608 FAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTE 672
            ||.|.|...||||.||||:.|:|||||||||...|.:||||||||..:|||.||||||||.||||
Mouse   201 FASRAGLGACWHPQCFVCTTCQELLVDLIYFYHAGKVYCGRHHAECLRPRCQACDEIIFSPECTE 265

  Fly   673 AEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQ 737
            ||||.|||.||.|.|||..||||||:||:.:|:|.||::...|||||.|||.||:|||||:::||
Mouse   266 AEGRHWHMGHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYEGQ 330

  Fly   738 HWHATDQCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPPTPSDTSSGPQLR----------- 791
            ||||:|:||.|..|...|||||||||||.|:||.|||.|.    ..|:.||..|
Mouse   331 HWHASDRCFCCSRCSRPLLGRPFLPRRGLIFCSRACSLGS----ETTAPGPGRRSWSAGTVTTPL 391

  Fly   792 PTHRAS------TSSQIAKSPRRGGERERDPGRKAH--HGHPKATGSAGDLLERQERQRMEAAGV 848
            .|..||      ||...:|......|....|...:|  .|.|             .|..|...|
Mouse   392 TTSTASFSATEGTSETASKGTCTKAEPAAGPEEPSHFLRGAP-------------HRHSMPELG- 442

  Fly   849 ADLLLGGGVPGMPRPAHPPPIDLTELGISLDNICAGDKSIFGDTQTLTNSMPDMLLSKADDSHSY 913
               |.....|....|.||.|              ..|.:.||...|...|..|.|:|:.....:
Mouse   443 ---LRSAPEPPTESPGHPAP--------------HPDDNAFGRQSTPRVSFRDPLVSEGGPRRT- 489

  Fly   914 QSIDKINLNSPSNSDLTQSTQELANELELDNEPVRELPHDGYEQLFANNRNQEHPAEQYDDEQLD 978
                   |::|.                                  |..|....|
Mouse   490 -------LSAPP----------------------------------AQRRRPRSP---------- 503

  Fly   979 NRPMKEVRFHSVQDTMSRSKSYTDNSNARRRRRRRNQSRSSSEMQINQTNLRLHNAQTQVGTTPL 1043
              |.:....|              :.:..||||:|::.|.|            |:.....|.
Mouse   504 --PPRTPSCH--------------HHHHHRRRRQRHRRRGS------------HHHHHHPGR--- 537

  Fly  1044 NLLNNLDNCDVAS-----ICSTCSSSSSSDM--DDYVY---RLPARKHYGGVRVAYVPNDALAYE 1098
               :....||:.|     .||:..||.||:.  ||..:   |:|...|.
Mouse   538 ---HGHHRCDLGSGSDSGSCSSSPSSPSSESSEDDGFFLGERIPLPPHL---------------- 583

  Fly  1099 RKKKMAQDSSLAPGAGNASVGGAPA--IMHES----------KNCTIS 1134
            .:.:..||:|       .....:||  ::.||          |||.::
Mouse   584 CRPRTTQDTS-------TETFNSPAQPLVQESHPVMPRQTRDKNCIVA 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	70/95 (74%)
		LIM1_Prickle	593..651	CDD:188799	35/57 (61%)
		LIM2_Prickle	656..711	CDD:188802	40/54 (74%)
		LIM3_Prickle	716..774	CDD:188804	40/57 (70%)
Prickle3	NP_001277553.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PET_Prickle	82..178	CDD:193602	70/99 (71%)
		LIM1_Prickle	186..244	CDD:188799	35/57 (61%)
		LIM2_Prickle	249..304	CDD:188802	40/54 (74%)
		LIM3_Prickle	309..367	CDD:188804	40/57 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..617		69/385 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842422
Domainoid	1	1.000	104	1.000	Domainoid score	I6681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3648
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm11117
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900