Protein Alignment esn and LMO7

DIOPT Version :10

• Sequence 1: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Sequence 2: XP_047286270.1
• Gene: LMO7 / 4008
• HGNCID: 6646
• Length: 1711
• Species: Homo sapiens
• Alignment Length: 1202
• Identity: 206/1202 - (17%)
• Similarity: 375/1202 - (31%)
• Gaps: 411/1202 - (34%)

  Fly    64 DSLSKS--SQAEAGKLFPRNMPSIRRSRR--RAVSAERERL---ASRERL------EEQVQPPKM 115
            ||:.:.  .|...|:|.   :|.:.:...  |.:.|:::.:   .:.:|.      |....||::
Human   531 DSVERDIILQCREGELV---LPDLEKDDMIVRRIPAQKKEVPLSGAPDRYHPVPFPEPWTLPPEI 592

  Fly   116 PQIGAGQQSRLSTVTKLTPRKQSSKSTCSKHRGNAPAKC-IIKSAVRTKTKPKATTITLAPYEIA 179
                  |...|..:.:..|.|:.|.|            | |:..:.|.| |....|..:..:::.
Human   593 ------QAKFLCVLERTCPSKEKSNS------------CRILVPSYRQK-KDDMLTRKIQSWKLG 638

  Fly   180 LELP--NESPAPTLAM------AVAQSSGCVQRK-LSSEDQFHSSGISCNGETDDDVEVAMLTGS 235
            ..:|  :.:|.|....      |:.::|....:| |..|..|.    ...||          .||
Human   639 TTVPPISFTPGPCSEADLKRWEAIREASRLRHKKRLMVERLFQ----KIYGE----------NGS 689

  Fly   236 LTPSQIAR--IQGQQILRYDDLRNL-NRCRNRNAVWLN------------------PKDTEQLLE 279
            .:.|.::.  :|..:.|||::::.: ::.:.::..|.:                  .|:..:.:|
Human   690 KSMSDVSAEDVQNLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIE 754

  Fly   280 ---VDKSRRKANCYFNQAIAD---DIQLSDI--EEQLARFDG---HSKRPPPPAATAPK------ 327
               ::||:|.:.. |.:.:.|   ..|.|.:  ..::..||.   ..||||....:...
Human   755 KQALEKSKRSSKT-FKEMLQDRESQNQKSTVPSRRRMYSFDDVLEEGKRPPTMTVSEASYQSERV 818

  Fly   328 ----ITQPSQVIEKFKPTPAPRS---SGNMQ---QAPQQQQHPHPPSSSYYTQTESELLQIEAGG 382
                .|.||::.::...|.|.|.   :..:|   |:|.::|.|...||.....|:.|..::.|
Human   819 EEKGATYPSEIPKEDSTTFAKREDRVTTEIQLPSQSPVEEQSPASLSSLRSRSTQMESTRVSA-- 881

  Fly   383 TGLTFASHSQRPESAISQVASTAHLDVPSAASSGSGGSAVSGGSGGAPESAGRFVSPLQRRHCQP 447
                     ..|.|    ...|..:.:.|..:....||...|            :|.|.|.:...
Human   882 ---------SLPRS----YRKTDTVRLTSVVTPRPFGSQTRG------------ISSLPRSYTMD 921

  Fly   448 PS-----------HLPLNSVASPLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALE 501
            .:           ..|.|.|::|   |....|:.:|.               :..|..:.....|
Human   922 DAWKYNGDVEDIKRTPNNVVSTP---APSPDASQLAS---------------SLSSQKEVAATEE 968

  Fly   502 EYTWVPPGLRPDQVRLYFSQLPDDK-------------VPYVNSPGEKYRVKQLLHQLPPQDNEV 553
            :.|.:|....|      ||.|..|:             :..::..||        .::.|| .||
Human   969 DVTRLPSPTSP------FSSLSQDQAATSKATLSSTSGLDLMSESGE--------GEISPQ-REV 1018

  Fly   554 RYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERPCKGCEEPLSGGDIVVFAQRLGAQLCW 618
                |.|.::..::||...|...::|.                               .|..:.|
Human  1019 ----SRSQDQFSDMRISINQTPGKSLD-------------------------------FGFTIKW 1048

  Fly   619 H-PGCFVCSV-------CKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIF--SDECTEA 673
            . ||.||.||       ..:|.||                           ||||.  :.:.:..
Human  1049 DIPGIFVASVEAGSPAEFSQLQVD---------------------------DEIIAINNTKFSYN 1086

  Fly   674 EGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQH 738
            :.:.|.......||..|.:...|   |.||              .|:     |.||..:
Human  1087 DSKEWEEAMAKAQETGHLVMDVR---RYGK--------------ADW-----GKDQPSL------ 1123

  Fly   739 WHATDQCFSCCTCRCSLLGRPFLPRRGTIYCSIACSK--GEPPTP----------SDTSSGPQLR 791
                                ||: |..|:..:...:|  |.|.|.          |:.||...:.
Human  1124 --------------------PFI-RHKTLNLTSMATKIIGSPETKWIDATSGIYNSEKSSNLSVT 1167

  Fly   792 PTHRASTSSQIAKSPRRGGERERDPGRKAHHGHPKATGSAGDLLERQERQRMEAAGVA----DLL 852
            .....|..|...:|....|..:..   .|.......:.|..:|..|.:.....::|.:    ..|
Human  1168 TDFSESLQSSNIESKEINGIHDES---NAFESKASESISLKNLKRRSQFFEQGSSGFSYSSWVYL 1229

  Fly   853 LGGG---VPGMPRPAHPPPIDLTELGISLDNICAGDKSIFGDTQTLTNSMPDMLL---------- 904
            .|..   ||.:|.|.           ||..:....|:......|.......|.||
Human  1230 CGSSDSVVPDLPVPT-----------ISAPSRWVWDQEEERKRQERWQKEQDRLLQEKYQREQEK 1283

  Fly   905 ---------SKADDSHSYQSIDKINLNSPSNSDLTQSTQELANELELDNEPVRELPHDGYEQLFA 960
                     .:|:..:|....:::.:.|.::..||.....||......:|..:....:|..   |
Human  1284 LREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDREGTR---A 1345

  Fly   961 NNRNQEHPAEQYDDEQLDNRPMKEVRFHSVQDTMSRSKSYTD-----------NSNARRRRRRRN 1014
            ....:..|.|:...|....:|..::       .:.|.:.:..           .:.|..::|...
Human  1346 GEEERRQPQEEVVHEDQGKKPQDQL-------VIERERKWEQQLQEEQEQKRLQAEAEEQKRPAE 1403

  Fly  1015 QSRSSSEMQINQTNLRLHNAQTQVGTTPLNLLNNLDNCDVASICSTCS---------SSSSSDMD 1070
            :.:..:|:: .:|::|::..:..|           |:.|:.......|         |.|::::|
Human  1404 EQKRQAEIE-RETSVRIYQYRRPV-----------DSYDIPKTEEASSGFLPGDRNKSRSTTELD 1456

  Fly  1071 DYVYRLPARKHYGGVRVAYVPNDALAYERKKK 1102
            ||    ...|:.....:..:.|...:..|.||
Human  1457 DY----STNKNGNNKYLDQIGNMTSSQRRSKK 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	21/108 (19%)
		LIM1_Prickle	593..651	CDD:188799	11/65 (17%)
		LIM2_Prickle	656..711	CDD:188802	12/56 (21%)
		LIM3_Prickle	716..774	CDD:188804	8/57 (14%)
LMO7	XP_047286270.1	CH_SF	<42..100	CDD:469584
		DUF4757	213..>275	CDD:464950
		DUF4757	627..774	CDD:464950	26/161 (16%)
		PDZ	1042..1110	CDD:214570	20/97 (21%)
		DUF5401	<1258..>1506	CDD:375164	38/253 (15%)
		LIM	1642..1700	CDD:259829