DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esn and Prickle4

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_001277266.1	Gene:	Prickle4 / 381104	MGIID:	2685785	Length:	369	Species:	Mus musculus

Alignment Length:	370	Identity:	137/370 - (37%)
Similarity:	184/370 - (49%)	Gaps:	73/370 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 SDDDSG-CALEEY-----------TWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLH 544
            :|.||| ..:|:|           :..||.|..:||.              |.||    .:.||.
Mouse    26 TDSDSGRRPVEDYEDTSAQAATCSSLGPPCLDINQVS--------------NWPG----FRTLLQ 72

  Fly   545 QLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLS---DERPCKGCEEPLSGGDIV 606
            ||||||::.|||.:|.:||..:||:|.||||:::||:|..|||.   :...||.|::.|..|:..
Mouse    73 QLPPQDSDERYCLALGEEELAQLRLFCAQRKQKSLGQGVARLLPPKLEGYTCKKCKKLLDPGEYG 137

  Fly   607 VFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECT 671
            |||.|.|.|.|||..||.|..|.:.|::||||..:|:|||||||||..:|||.|||::|||..||
Mouse   138 VFAARAGEQSCWHRPCFACQACGQGLINLIYFYHEGHLYCGRHHAELLRPRCPACDQLIFSQRCT 202

  Fly   672 EAEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDG 736
            ||||:.||..||.||:|...|.|.||.:..|.|.|.:||.   ..|.......:||.:||.|.:.
Mouse   203 EAEGQRWHENHFCCQDCAGPLDGGRYALPGGSPCCPSCFS---KRYRSAGSSSVGVAEGQASFEE 264

  Fly   737 Q------HWH---ATDQCFSCCTCRCSLLGR-PFLPRRGTIYCSIACSKGE----PPTP-SDTSS 786
            :      .|:   :.|:    .|.|.:||.. |.|    |:......||.:    |.|| |....
Mouse   265 EGPDPSVGWNRASSDDK----ITSRAALLSAVPTL----TLETLNGASKRQDRDGPQTPGSPIED 321

  Fly   787 GPQLRPTHRASTSSQIA------------KSPRRGGERERDPGRK 819
            .|  .||..:|:.|:..            |:|......:||..||
Mouse   322 SP--CPTCSSSSESEPEGFFFGQRLPEPWKTPENLQADDRDISRK 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	40/107 (37%)
		LIM1_Prickle	593..651	CDD:188799	30/57 (53%)
		LIM2_Prickle	656..711	CDD:188802	30/54 (56%)
		LIM3_Prickle	716..774	CDD:188804	15/67 (22%)
Prickle4	NP_001277266.1	PET_OEBT	1..116	CDD:193603	40/107 (37%)
		LIM1_Testin_like	124..181	CDD:188726	29/56 (52%)
		LIM2_Testin_like	187..241	CDD:188727	29/53 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770