DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and prickle2b

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_899186.1	Gene:	prickle2b / 368250	ZFINID:	ZDB-GENE-030724-6	Length:	840	Species:	Danio rerio

Alignment Length:	877	Identity:	309/877 - (35%)
Similarity:	400/877 - (45%)	Gaps:	278/877 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 DFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQ 549
            ||||||.||||||||||||.||||||:|:||..|:|.||:||||||||||||||:|||||||||.
Zfish    15 DFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSSLPEDKVPYVNSPGEKYRIKQLLHQLPPH 79

  Fly   550 DNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVR---LLSDERPCKGCEEPLSGGDIVVFAQR 611
            |||||:|:||.|||::||::||.|||||.||||.||   :......|:.|...::||||.|||.|
Zfish    80 DNEVRFCNSLDDEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASR 144

  Fly   612 LGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGR 676
            .|..:||||.|||||:|.|||||||||.:||.::|||||||..|||||||||||.:|||||||||
Zfish   145 AGHGVCWHPQCFVCSMCDELLVDLIYFYQDGKIFCGRHHAERLKPRCSACDEIILADECTEAEGR 209

  Fly   677 TWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHA 741
            .||||||.|.|||..||||||||:||:|||..||::::|||||.|||.||:|||||::|||||||
Zfish   210 HWHMKHFCCFECETVLGGQRYIMKEGRPYCCTCFESLYAEYCDSCGEHIGIDQGQMTYDGQHWHA 274

  Fly   742 TDQCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPPTPSDTS----SGPQLRPTHRASTSSQI 802
            |:.||||..|:.|||||||||::|.|:||.|||.|:....||:|    ...:.|...|:|:.|..
Zfish   275 TEACFSCARCKKSLLGRPFLPKQGQIFCSRACSVGDEQNGSDSSDSAFQSARSREARRSSSKSNK 339

  Fly   803 AKSPRRGGERERDPGRKAHHGHPKATGSA-------------GDLLE---------------RQE 839
            :.:...||:           ||.....||             .|||.               :.:
Zfish   340 SSTGGSGGD-----------GHQSGKASAMRFSADVDPLSLQMDLLSLSSQTPSLNRESPSWKTQ 393

  Fly   840 RQRMEAAGVADLL-------------------LGGGVPGMPRPAHP-----PPIDLTELGISLD- 879
            .:.....|..:|.                   |..|....|||..|     ||:...: |.||:
Zfish   394 AEMFGYEGRNELSTNPLHLLSQCNIRTSYSSNLSPGHLSDPRPKEPASSKRPPVSALK-GKSLNE 457

  Fly   880 -------------------------------------NICAGDK---------------SIFGDT 892
                                                 ::...:|               |..|.:
Zfish   458 NWFQQGPEDYYPPALRTQASFNEVPHNSFMDKRSVSLHVFQREKEKDVGPQMSRSRNPISALGFS 522

  Fly   893 QTLTN-----------------------------------SMPDM---------------LLSKA 907
            :.||.                                   ||||:               .|:.:
Zfish   523 EQLTPLEQTPRGSMESLALSNATGTSADGGSKRQEHLSRFSMPDLSKDSGMNVSEKSNMGTLNSS 587

  Fly   908 DDSHS-------------------------------------------YQSIDKINLNSPSNSDL 929
            ...||                                           ||..|:::|.|.:|:..
Zfish   588 VQFHSSESLRSLNSAQPYLELEAPVQVRFPVQYPREPSGINALPPGFAYQEEDRVSLVSNANNAR 652

  Fly   930 TQSTQELANELELDNEPVRELPH------------DGYEQLFAN-----NRNQEHPAEQYDDEQL 977
            .....|......:|:|..|...|            |....|.|.     .|:|.|..|.||
Zfish   653 LPPMSERTRRRSIDHEEPRRRHHHHRSRRSRRSRSDNALNLVAERRPALKRSQLHAREDYD---- 713

  Fly   978 DNRPMKEVRFHSVQDTMSRSKSYTDNSNARRRRRRRNQSRSSSEMQINQTNLRLHNAQTQVGTTP 1042
                         |..:.|....|..|...|::..|...|::|::.:....|..|..       |
Zfish   714 -------------QFPLPRGSRDTYGSGRLRQQPFRPCPRTTSDLTLQNPALHRHQG-------P 758

  Fly  1043 LNLLNNLDNCDVASICSTCSSSSSSDMDDYVYRLPARKHYGGVRVAYVPNDALAYERKKKMAQDS 1107
            .: .:..|..|  ..||||||||.|:.:.|....|..:   .:::.::.::.|.  ||    .:|
Zfish   759 YS-WDQYDYDD--DWCSTCSSSSESEDEGYFLGEPIPR---PIQLRHMTSEELL--RK----YNS 811

  Fly  1108 SLAPGAGNASVGGAPAIMH-----ESKNCTIS 1134
            |   |.|.:...|:...:|     :||||.||
Zfish   812 S---GLGASGQFGSRGQLHMRKRRKSKNCIIS 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	74/98 (76%)
		LIM1_Prickle	593..651	CDD:188799	36/57 (63%)
		LIM2_Prickle	656..711	CDD:188802	43/54 (80%)
		LIM3_Prickle	716..774	CDD:188804	41/57 (72%)
prickle2b	NP_899186.1	PET_Prickle	22..118	CDD:193602	74/95 (78%)
		LIM1_Prickle	126..184	CDD:188799	36/57 (63%)
		LIM2_Prickle	189..244	CDD:188802	43/54 (80%)
		LIM3_Prickle	249..307	CDD:188804	41/57 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586845
Domainoid	1	1.000	151	1.000	Domainoid score	I4309
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1235
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm6410
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.930