DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and prickle1a

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_899185.2	Gene:	prickle1a / 368249	ZFINID:	ZDB-GENE-030724-5	Length:	793	Species:	Danio rerio

Alignment Length:	832	Identity:	302/832 - (36%)
Similarity:	401/832 - (48%)	Gaps:	215/832 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 HGFHHS----HHQQLDFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPG 534
            ||..|.    :...|.|||:|.||||||||||||.||||||||:||.||||.||:||||||||||
Zfish     6 HGGLHMGSKVNKLTLGFQRSSTSDDDSGCALEEYAWVPPGLRPEQVALYFSCLPEDKVPYVNSPG 70

  Fly   535 EKYRVKQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLS---DERPCKGC 596
            ||.|:||||:||||.|||||||.|||:||:|||.:||.|||:||||||.:::|.   ....|:.|
Zfish    71 EKQRIKQLLYQLPPHDNEVRYCQSLSEEEKKELHMFSIQRKKEALGRGTLKILPRTVHHAACEHC 135

  Fly   597 EEPLSGGDIVVFAQRLGAQ-LCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSA 660
            .|.||||::.|...|..|. .||||.||.||.|.|||||||||..||.::|||||||..|||||:
Zfish   136 GERLSGGEMAVCVSRAAAAGQCWHPACFTCSTCSELLVDLIYFYHDGKVHCGRHHAELLKPRCSS 200

  Fly   661 CDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVI 725
            ||||||:|||||||||.||||||:|.|||..||||||||::|:|:|..||.:::||||..|.:.|
Zfish   201 CDEIIFADECTEAEGRHWHMKHFSCSECEVILGGQRYIMKDGRPFCCGCFQSLYAEYCQACAQHI 265

  Fly   726 GVDQGQMSHDGQHWHATDQCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPPTPSDTSSGPQL 790
            |||..||::||.||||||.||||..|:.||||.|||||:|.||||.|||.||....||:|..
Zfish   266 GVDHAQMTYDGLHWHATDACFSCAQCKSSLLGCPFLPRQGRIYCSKACSLGEDVQASDSSDS--- 327

  Fly   791 RPTHRASTSSQIAKSPRRG-GERERDPGRK-------AHHGHPKATGSAGDLLER---------- 837
              ..:::.|.:..:|.:.| ..|..|..|:       :::..|..:|:|.|.|.:
Zfish   328 --AFQSARSRESRRSVKMGKSSRSADQCRQSLLFSPASNYKFPGLSGNADDTLSKRLSQLNFADN 390

  Fly   838 ---QERQRMEAAG-----------VADLLLGGGVPGMPRP------------------------- 863
               :.|:..||..           :..|||..|..||.:.
Zfish   391 HFWRNREDQEAPEDHEEWAEHDDYMTQLLLKFGEHGMFQDTRTDLSIWTDSELKNKTCSGGNSSL 455

  Fly   864 ------------------------AHPPP--------IDLTELGISL---DNICAGDKSIFGDT- 892
                                    :||.|        :|| |.|.|.   ||     |..|.|:
Zfish   456 ASKKYKADMYWTQSQDGLGDSAYGSHPGPASSRKLQDLDL-EHGASFKHEDN-----KQWFNDSL 514

  Fly   893 QTLTNSMPDMLLSKADDSHS--------------------------YQSIDKINLNSPSNSDLTQ 931
            :.:|:.:.:..|:..|...|                          :..:|:.. |:.:...|..
Zfish   515 ECITDQLKEADLNIRDSMDSLALSNITGASVDGDIKDKPLLFSLQKFSDLDRCE-NTSNMGTLNS 578

  Fly   932 STQELANELE----LDNEPVRELP----HDGYEQLFANNRNQEHPAEQ---YDDEQLDNRPMKEV 985
            |.:.|.::|:    ::.:..:.:|    |....:|....|::.....|   :.|:.:||....|:
Zfish   579 SMKSLTSDLDRTQVIEEQQEQGVPSPEVHPKPPRLPVLRRSKSQSKTQQVKFSDDVIDNGRYDEL 643

  Fly   986 RFHS---VQDTMSRSKSYTDNSNAR----RRRRRRNQSRSSSEMQI--NQTNLRL---------- 1031
            :...   .:.|..|:..:.:..:.|    .||||...|||.:.:.:  .:...|:
Zfish   644 KVRQPPMSERTRRRAFQFDEQDHQRPRHHHRRRRSRMSRSDNALHLAPKEEKPRVCFKDDRRKHG 708

  Fly  1032 --HNAQTQVG----TTPLNLLNNLDNCDVASICSTCSSSSSSDMDDYVY--------RLPARKHY 1082
              ||. .|.|    |.....|...|      .|||||||||...::..:        |.|
Zfish   709 LGHNG-AQYGDGLRTERFTRLYEDD------WCSTCSSSSSESEEEGFFLGQPIPQPRQP----- 761

  Fly  1083 GGVRVAYVPNDALAYERKKKMAQDSSLAPGAGNASVGGAPAIMHESKNCTIS 1134
               |..|..:|..|:..:.|..|...                 .:.|||.||
Zfish   762 ---RYQYYASDEAAFSTRTKSKQKRG-----------------RKGKNCIIS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	75/95 (79%)
		LIM1_Prickle	593..651	CDD:188799	34/58 (59%)
		LIM2_Prickle	656..711	CDD:188802	41/54 (76%)
		LIM3_Prickle	716..774	CDD:188804	38/57 (67%)
prickle1a	NP_899185.2	PET_Prickle	28..124	CDD:193602	75/95 (79%)
		LIM1_Prickle	132..191	CDD:188799	34/58 (59%)
		LIM2_Prickle	196..251	CDD:188802	41/54 (76%)
		LIM3_Prickle	256..314	CDD:188804	38/57 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6711
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1235
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm6410
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860