DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esn and Prickle4

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	XP_038940411.1	Gene:	Prickle4 / 316212	RGDID:	1563979	Length:	368	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	140/408 - (34%)
Similarity:	181/408 - (44%)	Gaps:	114/408 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 PLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLP 523
            |:.|.|......|.|:|         |....:.:....|         ||  .||     .||..
  Rat    23 PVNTDSDSGHRPVQGYG---------DISVQAPTSSSLG---------PP--CPD-----ISQAS 62

  Fly   524 DDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLS 588
                   |.||    .:.||.||||||::.|||.:|.:||..:||:|.||||:::||:|..|||.
  Rat    63 -------NWPG----FRTLLQQLPPQDSDERYCLALGEEELAQLRLFCAQRKQKSLGQGVARLLP 116

  Fly   589 ---DERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHH 650
               :...|:.|::.|:.|:..|||.|.|.:.|||..||.|..|.:.|.:||||..||:|||||||
  Rat   117 PKLEGHTCEKCKKLLNPGEYGVFAARAGERCCWHRPCFACQACGQALTNLIYFYHDGHLYCGRHH 181

  Fly   651 AETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFA 715
            ||..:|||.|||::|||..|||||||.||..||.||:|...|.|.||.:..|.|.|.:||   ..
  Rat   182 AELLRPRCPACDQLIFSQRCTEAEGRHWHENHFCCQDCAEPLDGGRYALPGGSPCCPSCF---AR 243

  Fly   716 EYCDYCGEVIGVDQGQMS----HDG-------------------------QHWHATDQCFSCCTC 751
            .|.......||..:||.|    .||                         .|.||
  Rat   244 RYRSGGSSSIGAAEGQASLGNGGDGADLNGREQRLGLSMEGGNLPGQNPSPHTHA---------- 298

  Fly   752 RCSLLGRPFLPRRGTIYCSIACSKGEPPTPSDTSSGPQLRPTHRASTSSQI-------------A 803
               :|.:|.|.:...          .||.|.|.|.|  .|.:||||.:.::             .
  Rat   299 ---VLQQPLLQQHLV----------HPPQPPDASIG--ARSSHRASLACELQGPLEPTRRGCGAG 348

  Fly   804 KSPRRG-----GERERDP 816
            .:|:||     |.|.|.|
  Rat   349 LAPKRGRRSPTGGRRRGP 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	36/95 (38%)
		LIM1_Prickle	593..651	CDD:188799	29/57 (51%)
		LIM2_Prickle	656..711	CDD:188802	31/54 (57%)
		LIM3_Prickle	716..774	CDD:188804	14/86 (16%)
Prickle4	XP_038940411.1	PET_OEBT	1..116	CDD:193603	43/128 (34%)
		LIM1_Testin_like	124..181	CDD:188726	28/56 (50%)
		LIM2_Testin_like	187..241	CDD:188727	30/53 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910