DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and Prickle1

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_955428.1	Gene:	Prickle1 / 315259	RGDID:	735090	Length:	831	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	308/842 - (36%)
Similarity:	417/842 - (49%)	Gaps:	221/842 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 QRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQDN 551
            ||:|.||||||||||||.||||||||:|::|||:.||::|||||||||||:|:||||:||||.||
  Rat    17 QRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDN 81

  Fly   552 EVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSD---ERPCKGCEEPLSGGDIVVFAQRLG 613
            |||||.|||:||:|||::||||||:||||||.::|||.   ...|:.|...::||::.|||.|.|
  Rat    82 EVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAMMHAVCEQCGLQMNGGEVAVFASRAG 146

  Fly   614 AQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTW 678
            ..:||||.||||..|.|||||||||.:||.::|||||||..||||||||||||:|||||||||.|
  Rat   147 PGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHW 211

  Fly   679 HMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHATD 743
            |||||.|.|||..||||||||::|:|:|..||::::||||:.|||.||||..||::||||||||:
  Rat   212 HMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATE 276

  Fly   744 QCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPPTPSDTSSGPQLRPTHRASTSSQIAKSPRR 808
            .||||..|:.||||.||||::|.||||..||.||....||:|..     ..:::.|....:|.|.
  Rat   277 ACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDS-----AFQSARSRDSRRSVRM 336

  Fly   809 G-GERERDPGRKA-------HHGHPKATGSAGDLLER--------------------QERQRMEA 845
            | ..|..|..|::       ::..|..:|||.|.|.|                    :.|...||
  Rat   337 GRSSRSADQCRQSLLLSPALNYKFPGLSGSADDTLSRKLDDVSLSGQGAGFAHEEFWKARVDQEA 401

  Fly   846 AG-----------VADLLLGGG-------------------------VPGMPRP----------- 863
            :.           :..|||..|                         |...|..
  Rat   402 SEDPEEWAEHEDYMTQLLLKFGDKNLFQQPPSEVDMRASEHWIPDNMVTNKPEAKQNHQSLASKK 466

  Fly   864 --------------------AHPPPIDLTEL-GISLDNICAG---DK-----------SIFGDTQ 893
                                :||.|.....| .:.||:..||   |:           |.....|
  Rat   467 YQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAAGYNHDQTQWYEDSLECLSDLKPEQ 531

  Fly   894 TLTNSMPDMLLSKADDS------------HSYQSIDKI---------NLNSPSNSDLTQSTQELA 937
            ::.:||..:.||....:            :|.|:.::|         |:.:.::|.|.:|.:.|.
  Rat   532 SVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIEAEDCEKMSNMGTLNSSMLHRSAESLK 596

  Fly   938 NELELDNE--PVRELPHDG--YEQLFANNRNQEHPAE-QYDDEQLDN---------RPMKE---V 985
            :   |::|  |.:.:|.:.  :..:...:::|..|.: ::.|:.:||         .||.|   .
  Rat   597 S---LNSELCPEKIIPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRR 658

  Fly   986 RFHSVQDTMSR---------SKSYTDNS---------NARRRRR--------RRNQSRSSSEMQI 1024
            |.:..::..||         .||.:||:         :|:.|.|        :..||:.:.|:|.
  Rat   659 RVYHFEERGSRPHHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQSKGARELQA 723

  Fly  1025 NQTNLRLHNAQTQVGTTPLNLLNN--------LDNCDVASICSTCSSSSSSDMDDYVYRLP---A 1078
            ...|..|:.....  ||....|.|        |...|..|.||:.:|||.|:.:.|....|   .
  Rat   724 YMQNANLYGQYAH--TTSDYALQNPGMTRFLGLYGDDDDSWCSSSTSSSDSEEEGYFLGQPIPQP 786

  Fly  1079 RKHYGGVRVAYVPND------ALAYERKKKMAQDSSLAPGAGNASVGGAPAIMHESKNCTIS 1134
            |..    |..|..:|      ||...:..:....|....|             |..|||.||
  Rat   787 RPQ----RFTYYTDDLSSPASALPTPQFNQRTTKSKKKKG-------------HRGKNCIIS 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	74/95 (78%)
		LIM1_Prickle	593..651	CDD:188799	33/57 (58%)
		LIM2_Prickle	656..711	CDD:188802	42/54 (78%)
		LIM3_Prickle	716..774	CDD:188804	38/57 (67%)
Prickle1	NP_955428.1	PET_Prickle	22..118	CDD:193602	74/95 (78%)
		LIM1_Prickle_1	126..184	CDD:188867	33/57 (58%)
		LIM2_Prickle	189..244	CDD:188802	42/54 (78%)
		LIM3_Prickle	249..307	CDD:188804	38/57 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..346		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..688		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831		20/84 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4300
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm9129
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830