DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and Lpp

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	XP_038944025.1	Gene:	Lpp / 288010	RGDID:	1310535	Length:	797	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	179/880 - (20%)
Similarity:	277/880 - (31%)	Gaps:	273/880 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GSPTRHRSCDSLSKSSQAEAGKLFPRNMPSIRRSRRRA-----------------------VSAE 96
            ||||..|.|.              ||.:| :|..||.|                       ||.:
  Rat    16 GSPTSSRGCP--------------PRPLP-VRLVRRPAGTRLPIPYMDKCVQAKSGIQAPDVSLQ 65

  Fly    97 R--ERLASRERLEEQVQPPKMPQIGAG-QQSRLSTVTKLTPRKQSSKSTCS---KHRGNAPAKCI 155
            |  .|...|.:             |.| ::.|..|.:...|..:.|...|.   :.|.:.|.
  Rat    66 RSGHRTGDRGK-------------GVGRKEGRAPTSSHSRPAAEVSLFVCGFAPRARSSFPG--- 114

  Fly   156 IKSAVRTKTKP-------------KATTITL--------APYEIALELPNESPAPTL--AMAVAQ 197
            |.|....:::|             :|:.:.|        :|.:|..:|.:....|:.  ..:..:
  Rat   115 ISSVSGGESRPLQGGNTGSRTEVERASQVLLHLLLFTVVSPRDIVPQLISTMSHPSWLPPRSTGE 179

  Fly   198 SSGCVQRKLSSEDQFHSSGISCN-------------------------GETD----------DDV 227
            ..|.|..::.:...|.:..||.:                         ||.|          |..
  Rat   180 PLGHVPARMETTHSFGTPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLEDPG 244

  Fly   228 EVAMLTGSLTPSQIARIQGQQILRYDDLRNLNRCRNRNAVWLNPKDTEQLLEVDKSRRKANCYFN 292
            .:...:|...|.. ...:|..|::..                ||..  :.||..:|...|.....
  Rat   245 TIPSGSGHFPPPP-PLDEGAFIVQRG----------------NPGG--KTLEERRSSLDAEIDSL 290

  Fly   293 QAIADDIQLSDIEEQLARFDGHSKRPPPPAATAPKITQPSQVIEKFKPTPAPRSSGNMQQA---- 353
            .:|..|::.|...:..|.....|....||.:| |.......||.:..|..|.:.|....||
  Rat   291 TSILADLECSSPYKPRAPPGSSSSIASPPVST-PVTGHKRMVIPQQPPLTATKKSATKPQAIPIP 354

  Fly   354 --------PQQQQHPHPPSSSYYTQTESELLQIEAGGTGLTFASHSQRPESAISQVASTAHLDVP 410
                    ||    |.|..:||.|                  ||.|.||         ..::.|.
  Rat   355 VTPIGTLKPQ----PQPVPASYST------------------ASTSSRP---------AFNVQVK 388

  Fly   411 SAASSGSGGSAVSGGSGGAPESAGRFVSPLQRRHCQPPSHLPLNSVASPLRTASYKSAAAV---- 471
            ||..|    :....||     |:|:...|..|.:  ....:||::...|..|.:....|.:
  Rat   389 SAQPS----THYMTGS-----SSGQMYGPGSRSY--NTQQVPLSAQCPPPTTCAGTDYAYIPPSG 442

  Fly   472 --AGHGFHHSHHQQLDFQ-----------RNSQSDDDSGCALEEYTW------VPPGL-RPDQVR 516
              |..||.::.:|...|:           || ::|...|..::..||      ..||. ..:|..
  Rat   443 QQAESGFGYTSNQGRYFEPFFAACPSYGGRN-EADPAYGQQVQPNTWKREPGYAAPGAGNQNQPG 506

  Fly   517 LYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQDNEV---RYCHSLSDEERKELR---------- 568
            :|....|  |..|:..|..    ......:.|::..|   :...::.|:....||
  Rat   507 MYSVSGP--KKTYITDPVS----APCAPPVQPKERLVKNQKVLQNVVDDRVHGLRKSGFPAPMGP 565

  Fly   569 --IFSAQRKREALGRGAVRLLSD-ERP--------CKGCEEPLSGGDIVVFAQRLGAQLCWHPGC 622
              :..:.|..:.|.....::|.| |.|        |..|.|.:.|......|.    ...:|..|
  Rat   566 PSVPPSFRPEDELEHLTKKMLYDMENPPADDYFGRCARCGENVVGEGTGCTAM----DQVFHVDC 626

  Fly   623 FVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQE 687
            |.|.||...|....::..:...||...:..|.: :||.|.:.|. :....|.|:.:|...|.|..
  Rat   627 FTCMVCDIKLRGQPFYAVEKKAYCEPCYINTLE-QCSVCSKPIM-ERILRATGKAYHPHCFTCVM 689

  Fly   688 CEHQLGGQRYIMRE-GKPYCLACFDTMFAEYCDYCGEVIGVDQGQ--------MSHDGQHWHATD 743
            |...|.|..:.:.. |..:|:..|...||..|..|.|.|....||        :..| .|.|
  Rat   690 CHRSLDGIPFTVDACGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRD-FHVH--- 750

  Fly   744 QCFSCCTCRCSLL----GRPFLPRRGTIYCSIACS 774
             |:.|..|. .||    .:...|..|.|.|. :|:
  Rat   751 -CYRCEDCG-GLLSEGDNQGCYPLDGHILCK-SCN 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	19/117 (16%)
		LIM1_Prickle	593..651	CDD:188799	14/57 (25%)
		LIM2_Prickle	656..711	CDD:188802	14/55 (25%)
		LIM3_Prickle	716..774	CDD:188804	18/69 (26%)
Lpp	XP_038944025.1	PHA03247	<15..429	CDD:223021	96/505 (19%)
		dnaA	347..>534	CDD:237605	49/235 (21%)
		LIM1_TRIP6	601..654	CDD:188736	14/56 (25%)
		LIM	661..720	CDD:413332	17/59 (29%)
		LIM3_TRIP6	721..786	CDD:188820	19/69 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810