Protein Alignment esn and Prickle2

DIOPT Version :10

• Sequence 1: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Sequence 2: NP_001391015.1
• Gene: Prickle2 / 243548
• MGIID: 1925144
• Length: 937
• Species: Mus musculus
• Alignment Length: 1044
• Identity: 344/1044 - (32%)
• Similarity: 437/1044 - (41%)
• Gaps: 355/1044 - (34%)

  Fly   320 PPAATAPKITQPSQVIEKFKPTPAPRSSGNMQQAPQQQQHPHPPSSSYYTQTESELLQIEAG--- 381
            |..|..|..|..||     :|.|||.               ||.::..:.|. :.|.:||.|
Mouse    20 PSGAARPVPTAGSQ-----RPGPAPL---------------HPAAAHLWPQL-TGLGRIERGQPC 63

  Fly   382 --------GTGLTFASHSQRPESAISQVASTAHLDVPSAASSGSGGSAVSGGSGGAPESAGRFVS 438
                    |    ||.|..|        ....|...|
Mouse    64 NACGDQCPG----FALHKWR--------KICLHCKCP---------------------------- 88

  Fly   439 PLQRRHCQPPSHLPLNSVASPLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEY 503
              |..|......|.:....|.|                      ..||||:|.||||||||||||
Mouse    89 --QEEHMVTVMPLEMEKTISKL----------------------MFDFQRSSTSDDDSGCALEEY 129

  Fly   504 TWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYCHSLSDEERKELR 568
            .||||||:|:||..|:|.||::|||||||.|||.|:|||||||||.|||||||:||.:||::||:
Mouse   130 AWVPPGLKPEQVHQYYSCLPEEKVPYVNSAGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELK 194

  Fly   569 IFSAQRKREALGRGAVR---LLSDERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKE 630
            :||.|||||.||||.||   :......|:.|...:.||||.|||.|.|..:||||.||||:||.|
Mouse   195 LFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQIKGGDIAVFASRAGHGICWHPPCFVCTVCNE 259

  Fly   631 LLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQ 695
            ||||||||.:||.:||||||||..||||:|||||||:|||||||||.|||:||.|.|||..||||
Mouse   260 LLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMRHFCCFECETVLGGQ 324

  Fly   696 RYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHATDQCFSCCTCRCSLLGRPF 760
            ||||:||:|||..||::::|||||.|.:.||:|||||::||||||||:.||.|..|:.|||||||
Mouse   325 RYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPF 389

  Fly   761 LPRRGTIYCSIACSKGEPPTPSDTSSGPQLRPTHRASTSSQIAKSPRRGGERE------------ 813
            ||::|.|:||.|||.||.|..||:|.  ......||..|.:.||..:..|:.|
Mouse   390 LPKQGQIFCSRACSAGEDPNGSDSSD--SAFQNARAKESRRSAKIGKNKGKTEEAMLNQHSQLQV 452

  Fly   814 -----------------------------RDP-----------GRK------------------- 819
                                         |||           |.|
Mouse   453 SSNRLSADVDPLSVQMDLLSLSSQTPSLNRDPIWRSREEPFHYGNKMEQNQSQSPLQLLSQCNIR 517

  Fly   820 ------------------AHHGHPKATGS-------------------AGDLLERQERQRMEAAG 847
                              .|..:||.:.|                   .|.|:.::....|.:..
Mouse   518 TSYSPGGQGAGAQPDMWAKHFSNPKRSSSMALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQS 582

  Fly   848 VADLLLGGGVPGMP------------------RPAHP----------PPIDLTELG----ISLDN 880
            ..:  ..|.:| :|                  ||..|          .|.:.|..|    ::|.|
Mouse   583 FNE--TRGSIP-VPKYEEEEEEEEGGISTQQCRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSN 644

  Fly   881 ICAGDKSIFGDTQTLTN----SMPDMLLSKADDSHSYQSIDKINLNSPSNSDL------------ 929
              |...|..|..:...:    ||||  |||  ||....| :|::.....||.:
Mouse   645 --ATGLSAEGGAKRQEHLSRFSMPD--LSK--DSGMNVS-EKLSNMGTLNSSMQFRSAESVRSLL 702

  Fly   930 -TQSTQELANELELDNEPVRELPHDGYEQLFANNRNQEHPAEQYD----------DEQLDNRPMK 983
             .|..||:...|...:.|:      ||..|.::.|  .|.:..:|          .|.:..:||.
Mouse   703 SAQQYQEMEGNLHQLSNPL------GYRDLQSHGR--MHQSFDFDGGIASSKLPGQEGVHIQPMS 759

  Fly   984 EVRFHSVQDTMSRSKSYTDNSNAR-RRRRRRNQSRSSSEMQINQTN------------------- 1028
            |       .|..|:.|..||...| .|.||..:|||.:.:.:....
Mouse   760 E-------RTRRRTTSRDDNRRFRPHRSRRSRRSRSDNALHLASEREVIARLKERPPLRAREDYD 817

  Fly  1029 --LRLHNAQTQVGTTPLNLLNNLDNC-----DVA----------------SICSTCSSSSSSDMD 1070
              :|..:.|..:|......|  ...|     |:|                ..||||||||.||.:
Mouse   818 QFMRQRSFQESLGQGSRRDL--YSQCPRTVSDLALQNAFGERWGPYFTEYDWCSTCSSSSESDNE 880

  Fly  1071 DYVYRLPARKHYGGVRVAYVPNDALAYERKKKMAQDSSLAPGAGNASVGGAPAIMH-----ESKN 1130
            .|....|..:   ..|:.||.:|.|.::........||...|.|.         :|     :|||
Mouse   881 GYFLGEPIPQ---PARLRYVTSDELLHKYSSYGVPKSSTLGGRGQ---------LHSRKRQKSKN 933

  Fly  1131 CTIS 1134
            |.||
Mouse   934 CIIS 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	71/98 (72%)
		LIM1_Prickle	593..651	CDD:188799	37/57 (65%)
		LIM2_Prickle	656..711	CDD:188802	42/54 (78%)
		LIM3_Prickle	716..774	CDD:188804	38/57 (67%)
Prickle2	NP_001391015.1	PET_Prickle	118..214	CDD:193602	71/95 (75%)
		LIM1_Prickle	222..280	CDD:188799	37/57 (65%)
		LIM2_Prickle	285..340	CDD:188802	42/54 (78%)
		LIM3_Prickle	345..403	CDD:188804	38/57 (67%)