DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and LIMCH1

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	XP_011511944.1	Gene:	LIMCH1 / 22998	HGNCID:	29191	Length:	1655	Species:	Homo sapiens

Alignment Length:	1194	Identity:	216/1194 - (18%)
Similarity:	373/1194 - (31%)	Gaps:	324/1194 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QVQPPKMPQIGAGQQSRLSTVTKLTPRKQSSKSTCSKHRG--NAPAKCIIKSAVRTKTKPKATTI 171
            |.:||..|.....|:    .:.::|.|....|..   ..|  |....|.:.:|::.....|.
Human    15 QPEPPPEPAFSEAQK----WIEQVTGRSFGDKDF---RTGLENGILLCELLNAIKPGLVKKI--- 69

  Fly   172 TLAPYEIALELPNESPAPTLAM--AVAQSSGCVQRKLSSEDQFHSSGISCNGETDDDVEVAMLTG 234
                        |..|.|...:  .:....||.:..|.....|..|.:.   :|.:.|.|..|..
Human    70 ------------NRLPTPIAGLDNIILFLRGCKELGLKESQLFDPSDLQ---DTSNRVTVKSLDY 119

  Fly   235 SLTPSQIARIQGQQILRYDDLRNLNRCRNRNAVWLNPKDTEQLL--------EVDKSRRK----- 286
            |      .:::...:..|...:..|.|.:.:...||.|:.|.||        :::..:|.
Human   120 S------RKLKNVLVTIYWLGKAANSCTSYSGTTLNLKEFEGLLAQMRKDTDDIESPKRSIRDSG 178

  Fly   287 -ANCYFNQAIADDIQ-----LSDIEEQLARFDGHSKRPPPP---------------AATAPKITQ 330
             .:|:.::. :|.:.     ..|..:.|..|...|::.|.|               .:..|....
Human   179 YIDCWDSER-SDSLSPPRHGRDDSFDSLDSFGSRSRQTPSPDVVLRGSSDGRGSDSESDLPHRKL 242

  Fly   331 PSQVIEKFKPTPAPRSSGNMQQA-PQQQQHPHPPSSSYYT-----QTESELLQIEAGGTGLTFAS 389
            |.  ::|...:....|.|..:.| |..|..|:..:.:.|.     :.::|..:.....:..|...
Human   243 PD--VKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQTAYVPAPLRKKKAEREEYRKSWSTATSPL 305

  Fly   390 HSQRP-------ESAISQVASTAHLDVPSAASS-----GSGGSAVSGGSGGA-PESAGRFVSP-- 439
            ..:||       |...|:|.|... |.|:...:     ..||..:..|||.. |.|.|..|:|
Human   306 GGERPFSFPETIEEEGSEVGSAGE-DNPAGQMNPGWKPSDGGCELPDGSGKEHPSSDGAVVAPAP 369

  Fly   440 ---------LQRRHCQPPSHLPLNSVASPLRTASYKSAA----AVAG------HGF-HHSHHQQL 484
                     :|:|.....:.:.:...|.  |.||.|..:    |:..      :.| .|.|
Human   370 KSEEKDAAEIQKRKRLEQAGIKVMPAAQ--RFASQKQLSEEKEAIRDIVLRKENSFLTHQH---- 428

  Fly   485 DFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKV----------PYVNSPGEKYRV 539
              ..:|:::.:..|.|       |.|..|......:::...|.          ||.....||...
Human   429 --GNDSEAEGEVVCRL-------PDLEKDDFAARRARMNQTKPMVPLNQLLYGPYPKKGAEKSDG 484

  Fly   540 KQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERPCKGCEEPLSGG- 603
            .:.|.:...:...:.|..:....|..:|.:....|.:|:                   ||:.||
Human   485 SKQLSKGISKKRSLEYKRNQGHTEEVKLIVTCNMRAQES-------------------EPVEGGL 530

  Fly   604 ---------DIVVFAQRLGAQLCWH--PGCFVCSVCKELLVDLIYFQ--------RDGNL--YC- 646
                     |:.  .||:...|..|  |..|: ::......||..::        |||::  .|
Human   531 RKVPDLHKDDLA--QQRIQGSLAPHREPPSFI-TLSNITEADLETWERLKVSEKARDGDVQHICA 592

  Fly   647 -----------------GRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFAC-----QECE 689
                             ....|...|...|...:.:.....||.:.:.|  |..:.     :|.|
Human   593 SEPSPEIKAETAIRDDFANRKARASKKASSPRQKFVHFGPVTELDQQKW--KRLSIGKAGPREDE 655

  Fly   690 HQL--GGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHATDQCFSCCTCR 752
            .::  .|.:..|....|...|....                :|....:.|:        .|.|..
Human   656 EEVICHGSKIQMDSVSPVSAATSSL----------------KGHQIFNRQN--------DCRTMN 696

  Fly   753 CSLLGRPFLPRRGTIYCSI-------ACSKGEPPTPSDTSSGPQLRPTHRASTSSQIAKSPRRGG 810
            |   ||....||.:....:       .||.||.|..::..:..||....:..|.|    :| |..
Human   697 C---GRGDYCRRASWLAPVPESQEEWVCSLGECPRGTEEVTSKQLPQDGKEETES----AP-RDS 753

  Fly   811 ERERDPGRKAHHGHPKATGSAGDLLERQERQRMEAAGVADLL--------LGGGVPGMPRPAHPP 867
            ||.....|......|.....|.:         .||:|..:.|        .|.|:.|..:.....
Human   754 ERLSKAERSEDSSQPLVCPLASE---------CEASGTEEKLEKMTAPAWSGSGLKGQRKLDDSR 809

  Fly   868 PIDL--TELGISLDNICAGDKSI----FGDTQTLTNSMPDMLLSK---------ADDSHSYQSID 917
            ..|:  ...|:||.:..:.....    |...|.:..|...:.:..         :||:.|....|
Human   810 KDDMMARRTGMSLRHTGSNPNQFLPVPFAKQQDVEESSKGLPMKDQRYGPRTPVSDDAESTSMFD 874

  Fly   918 KINLNSPSNSDLTQSTQELANELELDNEPVRELPHDGYEQLFANNRNQEHPAEQYDDEQLDNRPM 982
               :.....:.:...::....:|:|.|..:|| ..|.::...|..:::.....|...::.:.|..
Human   875 ---MRCEEEAAVQPHSRARQEQLQLINNQLRE-EDDKWQDDLARWKSRRRSVSQDLIKKEEERKK 935

  Fly   983 KEVRFHSVQDTMSRSKS---YTDNSNARRRRRRR-----NQSRSSSEMQ-INQTNLRLHNAQTQV 1038
            .|........|..|.||   |.:....:.||.|.     ..:||..|.: |.|..:........|
Human   936 MEKLLAGEDGTSERRKSIKTYREIVQEKERRERELHEAYKNARSQEEAEGILQQYIERFTISEAV 1000

  Fly  1039 GTTPLNLLNNLDNCDVASICSTCSSSS---SSDMDD-----YVYR--LPARKHYGGVRVAYVPND 1093
                      |:..::..|.....|:.   ||.::|     |:.:  ||..|....|........
Human  1001 ----------LERLEMPKILERSHSTEPNLSSFLNDPNPMKYLRQQSLPPPKFTATVETTIARAS 1055

  Fly  1094 ALAYERKKKMAQDSSLAPGAGNAS 1117
            .|          |:|::.|:|:.|
Human  1056 VL----------DTSMSAGSGSPS 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	16/105 (15%)
		LIM1_Prickle	593..651	CDD:188799	17/97 (18%)
		LIM2_Prickle	656..711	CDD:188802	11/61 (18%)
		LIM3_Prickle	716..774	CDD:188804	9/64 (14%)
LIMCH1	XP_011511944.1	CH	26..138	CDD:237981	23/142 (16%)
		DUF4757	250..>311	CDD:292571	10/60 (17%)
		DUF4757	813..961	CDD:292571	25/151 (17%)
		GBP_C	<1340..1377	CDD:303769
		LIM	1585..1642	CDD:214528
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900