Protein Alignment esn and Zfp185

DIOPT Version :10

• Sequence 1: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Sequence 2: NP_033575.3
• Gene: Zfp185 / 22673
• MGIID: 108095
• Length: 486
• Species: Mus musculus
• Alignment Length: 739
• Identity: 128/739 - (17%)
• Similarity: 193/739 - (26%)
• Gaps: 357/739 - (48%)

  Fly     6 RWWKIRLPQVG------KQDQSRNYRDIVNLSECSSVLANTATTIS---DSS------------- 48
            |..|:|....|      |.|.|.:: .|..||.     .|.||:.|   |.|
Mouse    27 RQMKVRTTLKGDQSWITKHDDSEDH-TIEPLSR-----HNRATSFSSVRDESNARSPNARAPAGY 85

  Fly    49 ------TTTASSGSPTRHR--SCDSLSKSSQAEAG---------------------KLFPRNMPS 84
                  |.|..|.|.::||  ..:...:|:..:.|                     ||.|.|:
Mouse    86 IIRGVFTRTIDSSSHSQHRPSKTNGAPRSASGQLGAANSGHPLQSSGYKMTTEDYKKLAPYNI-- 148

  Fly    85 IRRSRRRAVSAERERLASRERLEEQVQPPKMPQIGAGQQSRLSTVTKLTPRKQSSKSTCSKHRGN 149
                ||.::|.          .||:..|....:.....|:.|..:.|..||:.|
Mouse   149 ----RRSSISG----------TEEEEVPFTPDEQKRRSQAALGVLRKTAPREHS----------- 188

  Fly   150 APAKCIIKSAVRTKTKPK--------ATTITLAPYEIALELPNESPAPTLAMAVAQSSGCVQRKL 206
                .::.:|.:|.:.|.        |..:.:...::..|...|.||                 |
Mouse   189 ----YVLSAAKKTTSSPTQELQSPFLAKRVDVVDEDVLPEKNQEPPA-----------------L 232

  Fly   207 SSEDQFHSSGISCNGETDDDVEVAMLTGSLTPSQIARIQGQQILRYDDLRNL---NRCRNRNAVW 268
            :..|...||.               .|..:...||.....:..|...||..|   :.|...||.
Mouse   233 ARPDPGRSSS---------------TTEKIAHRQITPPTAELHLVAPDLEALSTPDSCEENNAA- 281

  Fly   269 LNPKDTEQLLEVDKSRRKANCYFNQAIADDIQLSDIEEQLARFDGHSKRPPPPAATAPKITQPSQ 333
              ||..:::....:..:......:|.:||   ||.:|.|                     ..||.
Mouse   282 --PKIIKEIPGTLQDGQSDPTVASQQLAD---LSILEPQ---------------------GSPSG 320

  Fly   334 VIEKFKPTPAPRSSGNMQQAPQQQQHPHPPSSSYYTQTESELLQIEAGGTGLTFASHSQRPESAI 398
            ..::.|    .....||..:         |||...|.|                          |
Mouse   321 AEQQIK----AEDCTNMLMS---------PSSCMVTVT--------------------------I 346

  Fly   399 SQVASTAHLDVPSAASSGSGGSAVSG------------GSGGAPESAGRFVSPLQRRHCQPPSHL 451
            |..:..:.|.||..:|.....|.:.|            .|.|.|.|:          ||..||
Mouse   347 SDTSEQSQLCVPGVSSKVDSSSTIKGILFVKEYMNTSEVSSGKPVSS----------HCDSPS-- 399

  Fly   452 PLNSVASPLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPGLRPDQVR 516
                                       |....||..:
Mouse   400 ---------------------------SIEDSLDLAK---------------------------- 409

  Fly   517 LYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYC-HSLSDEERKELRIFSAQRKREALG 580
                     |.|:..:|.|:           |.:....|| |.:.|
Mouse   410 ---------KAPHEGTPSER-----------PTEGVCTYCSHEIQD------------------- 435

  Fly   581 RGAVRLLSDERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKEL---LVDLIYFQRDG 642
                           |.:        :..:.||  :|.|..||.|.:|.:.   |:|.|:..||
Mouse   436 ---------------CPK--------ITLEHLG--ICCHEYCFKCGICNKPMGDLLDQIFIHRD- 474

  Fly   643 NLYCGRHHAETQKPRCSACDEIIF 666
            .::||:            |.|.:|
Mouse   475 TIHCGK------------CYEKLF 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	9/96 (9%)
		LIM1_Prickle	593..651	CDD:188799	16/60 (27%)
		LIM2_Prickle	656..711	CDD:188802	3/11 (27%)
		LIM3_Prickle	716..774	CDD:188804
Zfp185	NP_033575.3	LIM	425..481	CDD:214528	20/112 (18%)