DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esn and Lpp

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_001139424.1	Gene:	Lpp / 210126	MGIID:	2441849	Length:	613	Species:	Mus musculus

Alignment Length:	593	Identity:	125/593 - (21%)
Similarity:	189/593 - (31%)	Gaps:	192/593 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 DIQLSDIEEQLARFDGHSK-RPPPPAATAPKITQP----------SQVIEKFKP-TPAPRSSGNM 350
            |.::..:...||..:..|. :|.||..:|..|..|          ..||.:..| |...:|:...
Mouse   119 DAEIDSLTSILADLECSSPYKPRPPQGSASSIASPPVSTPVTGHKRMVIPQQPPLTATKKSATKP 183

  Fly   351 QQAPQQ-----------QQHPHPPSSSYYTQTESELLQIEAGGTGLTFASHSQRPESAISQVAST 404
            |.|||.           :..|.|..:||                  |.||.|.||         |
Mouse   184 QPAPQAAPIPVTPIGTLKPQPQPVPASY------------------TTASTSSRP---------T 221

  Fly   405 AHLDVPSAASSGSGGSAVSGGS--GGAPESAGRFVSPLQRRHCQPPSHLPLNSVASPLRTASYKS 467
            .::.|.||..|....:..|.|.  |..|........|:..: |.||          |....:..:
Mouse   222 FNVQVKSAQPSPHYMAGPSSGQIYGPGPRGYNNQPVPVSGQ-CPPP----------PTCVGTDYA 275

  Fly   468 AAAVAGH----GFHHSHHQQLDFQ----------RNSQSDDDSGCALEEYTW------VP----- 507
            ....:||    |:.::.:|...::          ..|:.|...|..::..||      .|
Mouse   276 YIPPSGHPPESGYGYTSNQGRYYEPYYAAGPSYGGRSEGDTAYGQQVQPNTWKREAAYAPPASGN 340

  Fly   508 ---PGLRP----------DQVRL-----------YFSQLPDDKVPYVNSPGE--KYRVKQLLHQL 546
               ||:.|          |.|..           |...:....:|....|.:  ::..|::|:.:
Mouse   341 QNHPGMYPVSGPKKTYITDPVSAPCAPPLQPKGGYPGPMGPPSIPPSFRPEDELEHLTKKMLYDM 405

  Fly   547 --PPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERPCKGCEEPLSGGDIVVFA 609
              ||.|:....|               |:.....:|.|.           ||    :..|.|
Mouse   406 ENPPADDYFGRC---------------ARCGENVVGEGT-----------GC----TAMDQV--- 437

  Fly   610 QRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAE 674
                    :|..||.|.||...|....::..:...||...:..|.: :||.|.:.|. :....|.
Mouse   438 --------FHVDCFTCIVCDVKLRGQPFYAVEKKAYCEPCYINTLE-QCSVCSKPIM-ERILRAT 492

  Fly   675 GRTWHMKHFACQECEHQLGGQRYIMRE-GKPYCLACFDTMFAEYCDYCGEVIGVDQGQ------- 731
            |:.:|...|.|..|...|.|..:.:.. |..:|:..|...||..|..|.|.|....||
Mouse   493 GKAYHPHCFTCVMCHRSLDGIPFTVDACGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIV 557

  Fly   732 -MSHDGQHWHATDQCFSCCTCRCSLL----GRPFLPRRGTIYCSIACSKGEPPTPSDTSSGPQLR 791
             :..| .|.|    |:.|..|. .||    .:...|..|.|.|.             |.:..::|
Mouse   558 ALDRD-FHVH----CYRCEDCG-GLLSEGDNQGCYPLDGHILCK-------------TCNSARIR 603

  Fly   792 P-THRAST 798
            . |.:|||
Mouse   604 VLTAKAST 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	22/134 (16%)
		LIM1_Prickle	593..651	CDD:188799	13/57 (23%)
		LIM2_Prickle	656..711	CDD:188802	14/55 (25%)
		LIM3_Prickle	716..774	CDD:188804	18/69 (26%)
Lpp	NP_001139424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		125/593 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..259		35/152 (23%)
		PRK14971	<139..>240	CDD:237874	30/127 (24%)
		dnaA	192..>388	CDD:237605	41/233 (18%)
		LIM1_TRIP6	417..470	CDD:188736	17/93 (18%)
		LIM	477..536	CDD:351770	17/59 (29%)
		LIM	537..602	CDD:351770	19/83 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810