DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esn and pin-2

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	NP_001255672.1	Gene:	pin-2 / 178234	WormBaseID:	WBGene00004030	Length:	330	Species:	Caenorhabditis elegans

Alignment Length:	243	Identity:	59/243 - (24%)
Similarity:	83/243 - (34%)	Gaps:	73/243 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 RPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQK 655
            |.|:.|.|.....:....   |||. .||..||:|:.|.:.||...|||.:..:||.........
Worm    19 RACERCREQFELNEPYFL---LGAS-SWHMRCFLCAQCMDPLVGTTYFQFENRIYCEHDFKTLYA 79

  Fly   656 PRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQ---RY-------IMREGKP------ 704
            |.|:.|:|.:.. :...:...::|:..|.|.||...|..|   ||       :..:.||
Worm    80 PVCAKCNEFVIG-QVVHSSNNSYHLACFTCDECNVHLNSQIAYRYQGTILCFLCNQKKPKMRIYN 143

  Fly   705 ----------------------------------------------YCLACFDTMFAEYCDYCGE 723
                                                          :|..||| ...|.|..|.:
Worm   144 CNKCKQHVDNSDLLTYQENPYHAYHFKCTTCKKVLESDARTIKDDLFCPRCFD-FKCEVCFDCKK 207

  Fly   724 VIG--VDQGQMSHDGQHWHATDQCFSCCTCRCSLLGRPFLPRRGTIYC 769
            ||.  |:|...:.: :||| ||. |.|.||.....|.....:.|..||
Worm   208 VIDPQVEQSIFTMN-KHWH-TDH-FRCATCARPFFGHEHYEKNGKAYC 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602
		LIM1_Prickle	593..651	CDD:188799	19/57 (33%)
		LIM2_Prickle	656..711	CDD:188802	17/116 (15%)
		LIM3_Prickle	716..774	CDD:188804	20/56 (36%)
pin-2	NP_001255672.1	LIM1_PINCH	21..79	CDD:188717	19/61 (31%)
		LIM	82..133	CDD:295319	12/51 (24%)
		LIM	144..195	CDD:295319	1/50 (2%)
		LIM4_PINCH	200..256	CDD:188720	20/56 (36%)
		LIM	264..315	CDD:295319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910