DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and PRICKLE2

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	XP_011531734.1	Gene:	PRICKLE2 / 166336	HGNCID:	20340	Length:	966	Species:	Homo sapiens

Alignment Length:	1051	Identity:	340/1051 - (32%)
Similarity:	443/1051 - (42%)	Gaps:	362/1051 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 PRSSGNMQQAP-----QQQQHPHPPSSSYYTQTESELLQIEAG-----------GTGLTFASHSQ 392
            |||||..::||     :.:..|..|::::.....:.|.:||.|           |    ||.|..
Human    18 PRSSGADRRAPPAGRERPRAAPLRPAAAHLWPQLTGLGRIERGQPCNACGDQCPG----FALHKW 78

  Fly   393 RPESAISQVASTAHLDVPSAASSGSGGSAVSGGSGGAPESAGRFVSPLQRRHCQPPSHLPLNSVA 457
            |        ....|...|                              |..|......|.:....
Human    79 R--------KICLHCKCP------------------------------QEEHMVTVMPLEMEKTI 105

  Fly   458 SPLRTASYKSAAAVAGHGFHHSHHQQLDFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQL 522
            |.|                      ..||||||.||||||||||||.||||||:|:||..|:|.|
Human   106 SKL----------------------MFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCL 148

  Fly   523 PDDKVPYVNSPGEKYRVKQLLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVR-- 585
            |::|||||||||||.|:|||||||||.|||||||:||.:||::||::||:|||||.||||.||
Human   149 PEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPF 213

  Fly   586 -LLSDERPCKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRH 649
             :......|:.|...::||||.|||.|.|..:||||.||||:||.|||||||||.:||.:|||||
Human   214 PVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRH 278

  Fly   650 HAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMF 714
            |||..||||:|||||||:|||||||||.||||||.|.|||..||||||||:||:|||..||::::
Human   279 HAECLKPRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLY 343

  Fly   715 AEYCDYCGEVIGVDQGQMSHDGQHWHATDQCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPP 779
            |||||.|.:.||:|||||::||||||||:.||.|..|:.|||||||||::|.|:||.|||.||.|
Human   344 AEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDP 408

  Fly   780 TPSDTSSGPQLRPTHRASTSSQIAKSPRRGGERE------------------------------- 813
            ..||:|.  ......||..|.:.||..:..|:.|
Human   409 NGSDSSD--SAFQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDML 471

  Fly   814 ----------RDP-----------GRK-------------------------------------A 820
                      |||           |.|                                     .
Human   472 SLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGK 536

  Fly   821 HHGHPK------ATGSAGDLLE-----------------------------------RQERQRME 844
            |..:||      .||.||..::                                   :.|.:..|
Human   537 HFSNPKRSSSLAMTGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKYEEEEEE 601

  Fly   845 AAGVADLLLGGGVPGMPRPAHP----------PPIDLTELG----ISLDN-----ICAGDKSIFG 890
            ..|::        ....|..||          .|.:.|..|    ::|.|     :....:....
Human   602 EGGLS--------TQQCRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGSSLAEHSRVTIT 658

  Fly   891 DTQTLTN---------------------------SMPDMLLSKADDSHSYQSIDKINLNSPSNSD 928
            :|:.::.                           ||||  |||  ||....| :|::.....||.
Human   659 ETEIISRYVWILTGINVGLSADGGAKRQEHLSRFSMPD--LSK--DSGMNVS-EKLSNMGTLNSS 718

  Fly   929 L-------------TQSTQELANELELDNEPVRELPHDGYEQLFANNRNQEHPAEQYDDEQLDNR 980
            :             .|..||:...|...:.|:      ||..|.::.|  .|.:..:|.....::
Human   719 MQFRSAESVRSLLSAQQYQEMEGNLHQLSNPI------GYRDLQSHGR--MHQSFDFDGGMAGSK 775

  Fly   981 -PMKE-VRFHSVQD-TMSRSKSYTDNSNAR-RRRRRRNQSRSSSEMQINQTNLRLHNAQTQVGTT 1041
             |.:| ||...:.: |..|:.|..||...| .|.||..:|||.:.:.:......:...:.:   .
Human   776 LPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDR---P 837

  Fly  1042 PLNLLNNLD----------------------NC-----DVA----------------SICSTCSS 1063
            ||....:.|                      .|     |:|                ..||||||
Human   838 PLRAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSS 902

  Fly  1064 SSSSDMDDYVYRLPARKHYGGVRVAYVPNDALAYERKKKMAQDSSLAPGAGNASVGGAPAIMH-- 1126
            ||.||.:.|....|..:   ..|:.||.:|.|.::........||...|.|.         :|
Human   903 SSESDNEGYFLGEPIPQ---PARLRYVTSDELLHKYSSYGLPKSSTLGGRGQ---------LHSR 955

  Fly  1127 ---ESKNCTIS 1134
               :||||.||
Human   956 KRQKSKNCIIS 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	72/98 (73%)
		LIM1_Prickle	593..651	CDD:188799	37/57 (65%)
		LIM2_Prickle	656..711	CDD:188802	43/54 (80%)
		LIM3_Prickle	716..774	CDD:188804	38/57 (67%)
PRICKLE2	XP_011531734.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152356
Domainoid	1	1.000	149	1.000	Domainoid score	I4411
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1323
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm8650
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790