DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esn and prickle3

DIOPT Version :9

Sequence 1:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster
Sequence 2:	XP_031747016.1	Gene:	prickle3 / 100490600	XenbaseID:	XB-GENE-940034	Length:	571	Species:	Xenopus tropicalis

Alignment Length:	572	Identity:	212/572 - (37%)
Similarity:	287/572 - (50%)	Gaps:	128/572 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 SGGSAVS-GGSGGAPESAGR----FVSPLQRR---HCQPPSHLPLNSVASPLRTASYKSAAAVAG 473
            |.||.|: .|.|....|.|.    |::...|:   |||.|..                      .
Frog    10 SQGSEVNLTGQGQPCHSCGERCPGFLAHRWRKICQHCQCPWE----------------------E 52

  Fly   474 HGFHHSHHQQLD---------FQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPY 529
            || |.:.:|.|:         .||:|..|..|..:||:|.|.|.||.|.||..:|...|:.|:||
Frog    53 HG-HTASNQDLERSLCRLVSGSQRDSLCDSGSDSSLEKYAWAPSGLNPMQVHQFFKCFPEKKIPY 116

  Fly   530 VNSPGEKYRVKQLLHQLPPQDNE-----------------------VRYCHSLSDEERKELRI-F 570
            ::||||:||:|||||||||.|:|                       .|||.||..||.:||.: |
Frog   117 ISSPGERYRLKQLLHQLPPHDSETWCCCLFCARPSTAVSCKLVLSQARYCCSLQGEEEEELLVLF 181

  Fly   571 SAQRKREALGRGAVRLLSDERP---CKGCEEPLSGGDIVVFAQRLGAQLCWHPGCFVCSVCKELL 632
            |.:|:.|.||||.||.:|....   |:.|...:|.||:.|||.|.|...||||.||.|:.|.|||
Frog   182 SQKRRLENLGRGCVRPVSGTMSGTVCQQCGHQISVGDVAVFASRAGLGFCWHPQCFTCAQCLELL 246

  Fly   633 VDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTWHMKHFACQECEHQLGGQRY 697
            .|||||.:||.:||||||||.::|||.||||:|||.|||:|||..||.:||.|.|||..|||.||
Frog   247 CDLIYFYQDGKVYCGRHHAELKRPRCLACDEVIFSLECTQAEGFHWHTRHFCCFECECPLGGHRY 311

  Fly   698 IMREGKPYCLACFDTMFAEYCDYCGE------VIGVDQGQMSHDGQHWHATDQCFSCCTCRCSLL 756
            ||::.:|:|.:|:|.::|:|||.|||      ::|:|:||:::.||||||::.||.|..|...||
Frog   312 IMKDQRPFCCSCYDRLYAQYCDSCGECIDGLFLLGIDEGQLTYGGQHWHASESCFCCGRCGVCLL 376

  Fly   757 GRPFLPRRGTIYCSIACSKGEPPTPSDTSSGPQLRPTHRASTSSQIAKSPRRGGERERDPGRKAH 821
            |||||||:|.||||.:||...  |..:.|..|       ..|...:.|       ..:|.|...:
Frog   377 GRPFLPRQGQIYCSRSCSILH--TKPERSFSP-------LQTELSLQK-------ETKDVGTSTN 425

  Fly   822 HGHPKATGSAGDLLERQERQRMEAAGVADLLLGGG------VPGMPRPAHPPPIDLTELGISLDN 880
            |.                   :|...:.|..|||.      :..:| .:...||.      ||.:
Frog   426 HD-------------------IEGDSINDCTLGGSRRSLSVIDQVP-TSRGAPIR------SLHS 464

  Fly   881 ICAGDKSIFGDTQTLTNSMPDMLLSKADDSHSYQSIDKINLNSPSNSDLTQS 932
            ...|....|........|:||:      .||: ::..::....|.:|::.:|
Frog   465 SLRGAPREFSRESPNRRSLPDL------SSHT-RTPTRVTFQIPLSSEIKES 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	53/119 (45%)
		LIM1_Prickle	593..651	CDD:188799	33/57 (58%)
		LIM2_Prickle	656..711	CDD:188802	34/54 (63%)
		LIM3_Prickle	716..774	CDD:188804	34/63 (54%)
prickle3	XP_031747016.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7186
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm14087
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010