DRSC/TRiP Functional Genomics Resources

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Protein Alignment dbo and KLHL21

DIOPT Version :10

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_055666.2 Gene:KLHL21 / 9903 HGNCID:29041 Length:597 Species:Homo sapiens


Alignment Length:599 Identity:201/599 - (33%)
Similarity:285/599 - (47%) Gaps:61/599 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 VDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLN-VGGRKIFAHRVILSACSSYFCAMF 101
            ::||...|.|..:...|....|..|:.||..|:..||.|. .|||...|||.:|:|.|.||.|||
Human     1 MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMF 65

  Fly   102 TGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLK 166
            .|:|.|||...|.:..:..:.::||:||.||..:.|...|.:.||.||.|||...:::.|..||:
Human    66 AGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130

  Fly   167 RQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRS 231
            :|||..|||.::.||:..||..|...|.:|...:..| :.:|:...||:.:|:..:..|.|.|..
Human   131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPK 194

  Fly   232 EEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKN 296
            ||..:...:.|::.:...|..|..|:|:.||||.:...:|:..|.::.||.....|..|:.||::
Human   195 EEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARD 259

  Fly   297 YLLLPQER----PLMQGPRTRPRKPTRRGEVLFAVGGWCSGDA--IASVERFDPQTNDWKMVAPM 355
            :.....:|    |.   ||.|||..|...|:|..||| |..|.  :.:|:.::|||..|:.:|..
Human   260 FQAARYDRHDRGPC---PRMRPRPSTGLAEILVLVGG-CDQDCDELVTVDCYNPQTGQWRYLAEF 320

  Fly   356 SKR-RCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFL 419
            ... ..|..:..|.:.:|..||.||....:.:.||:...|:|: :|||....|.....:||||.|
Human   321 PDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWA-EVAPMLKAREYHSSSVLDGLL 384

  Fly   420 YAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDG------QCPL 478
            |.|..       :..||||...:.|..:.|||......:.....|.|||||...|      ||  
Human   385 YVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQC-- 440

  Fly   479 NTVERYDPRHNKWVAVS-----PMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTW 538
                 |||..:.|..|.     |.|...|   .|..|..:|.|  |||..|:   :.|||..|.|
Human   441 -----YDPDTDLWSLVDCGQLPPWSFAPK---TATLNGLMYFV--RDDSAEV---DVYNPTRNEW 492

  Fly   539 SPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLK-TIEVYDPETNQWRLCGCMNYRRL------ 596
            ..|.:|.....|..|||:.|:||..||:|.:..|. .:|.|||||..|.:.|     ||      
Human   493 DKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVG-----RLPEPTFW 552

  Fly   597 GGGVGVMR--APQT 608
            .|.|.:.|  .|||
Human   553 HGSVSIFRQFMPQT 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 52/127 (41%)
PHA03098 69..587 CDD:222983 183/537 (34%)
KELCH repeat 359..403 CDD:276965 13/43 (30%)
KELCH repeat 407..451 CDD:276965 14/43 (33%)
KELCH repeat 454..497 CDD:276965 14/53 (26%)
KELCH repeat 501..545 CDD:276965 15/43 (35%)
KELCH repeat 548..593 CDD:276965 19/45 (42%)
KLHL21NP_055666.2 BTB_POZ_KLHL21 14..138 CDD:349559 50/123 (41%)
PHA03098 49..547 CDD:222983 178/530 (34%)
BACK_KLHL21 133..232 CDD:350535 31/99 (31%)
Kelch 1 287..335 14/48 (29%)
KELCH repeat 326..368 CDD:276965 13/42 (31%)
Kelch 2 336..382 15/46 (33%)
KELCH repeat 372..409 CDD:276965 14/43 (33%)
Kelch 3 384..422 11/44 (25%)
KELCH repeat 412..451 CDD:276965 13/45 (29%)
Kelch 4 423..470 17/56 (30%)
Kelch 5 472..512 17/44 (39%)
KELCH repeat 502..548 CDD:276965 21/50 (42%)
Kelch 6 513..560 18/51 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 570..597
Blue background indicates that the domain is not in the aligned region.

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