DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and KEAP1

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_036421.2	Gene:	KEAP1 / 9817	HGNCID:	23177	Length:	624	Species:	Homo sapiens

Alignment Length:	615	Identity:	230/615 - (37%)
Similarity:	341/615 - (55%)	Gaps:	39/615 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GGGSSV--GSTAVDRPPSPAR-----LSHTSEKHPKVTLTELNMLRRHRELCDVVLNV-----GG 80
            |.|.:|  .||......:|::     .|:|.|.|.|.....:|.||..::||||.|.|     ..
Human    26 GAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPA 90

  Fly    81 RKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTL 145
            .:..||:|:|::.|..|.||||..|.|.....|:|..|....||.||:|.|||.|.:.|..|..:
Human    91 AQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHV 155

  Fly   146 LPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEF 210
            :..|.:.|:..:...|.:||.:||||:|.:||..||:...|.||.:.|.::...:|.||.:.|||
Human   156 MNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEF 220

  Fly   211 LLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTV 275
            ..|...|||.:|..|:||||.|.:||:|.::|:||:..:||.::..:|:.||...|:|.||...:
Human   221 FNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQL 285

  Fly   276 GSDLLVRSDEACRDLVDEAKNYLL-LPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASV 339
            ....:::||..|:|       ||: :.:|..|.:..:..|.:..:.|.:::..||:.. .:::.:
Human   286 QKCEILQSDSRCKD-------YLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFR-QSLSYL 342

  Fly   340 ERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGH----DGQSYLNSIERYDPQTNQWS-CD 399
            |.::|....|..:|.:...|.|:...|:..|||||||.    ||.:..::::.|:|.||||| |
Human   343 EAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPC- 406

  Fly   400 VAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNH--VERYDPKENKWSKVAPMTTRRLGVAVAVL 462
             ||.:..|..:||.|:||.:|||||..|  |::|  ||||:|:.::|..||||.|||:||.||||
Human   407 -APMSVPRNRIGVGVIDGHIYAVGGSHG--CIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL 468

  Fly   463 GGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSS 527
            ...|||:||.||...||:.|.|.|..|:|..::.|:|.|...|..|.:|.|||.||.|...:|:|
Human   469 NRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNS 533

  Fly   528 AERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMN 592
            .|||:..|.||:.:..|..|||.:|:.|..|::|.:||:||..:|.::|.|||:|:.|.....|.
Human   534 VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMT 598

  Fly   593 YRRLGGGVGVMRAPQTENYMWCENSFKQPN 622
            ..|.|.||.|...|       |.....|.|
Human   599 SGRSGVGVAVTMEP-------CRKQIDQQN 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	49/131 (37%)
		PHA03098	69..587	CDD:222983	206/530 (39%)
		KELCH repeat	359..403	CDD:276965	21/48 (44%)
		KELCH repeat	407..451	CDD:276965	23/45 (51%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	18/43 (42%)
		KELCH repeat	548..593	CDD:276965	18/44 (41%)
KEAP1	NP_036421.2	BTB_POZ_KLHL19_KEAP1	56..180	CDD:349557	44/123 (36%)
		PHA03098	95..596	CDD:222983	200/512 (39%)
		Kelch 1	327..372		9/45 (20%)
		KELCH repeat	362..409	CDD:276965	21/48 (44%)
		Kelch 2	373..423		23/51 (45%)
		KELCH repeat	413..456	CDD:276965	22/44 (50%)
		Kelch 3	424..470		27/47 (57%)
		KELCH repeat	460..503	CDD:276965	21/42 (50%)
		Kelch 4	471..517		19/45 (42%)
		KELCH repeat	507..551	CDD:276965	18/43 (42%)
		Kelch 5	518..564		20/45 (44%)
		KELCH repeat	554..597	CDD:276965	17/42 (40%)
		Kelch 6	565..611		18/45 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820