DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and Klhl1

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_444335.2	Gene:	Klhl1 / 93688	MGIID:	2136335	Length:	751	Species:	Mus musculus

Alignment Length:	612	Identity:	255/612 - (41%)
Similarity:	376/612 - (61%)	Gaps:	29/612 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AQPRDAAVTGTGGNSTAGGGSSVGSTAVDRPPSPARLSHTSEK------HPKVTLTELNMLRRHR 69
            |:|. :::..||    .|.|..:.||.....|.....|.:||:      |.:.:..::....:.:
Mouse   153 AEPA-SSIQATG----EGCGHRLTSTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQ 212

  Fly    70 ELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAH 134
            :||||:|.||.|||.|||::||:.|.||.||||.::.|::|.|:.:..||.||:..|:.|.||..
Mouse   213 QLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGC 277

  Fly   135 IIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQH 199
            :.::|..::.||.|||||||.::.::||.||.:.|.|:||||||||||...|.||:::|..:|..
Mouse   278 LELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTME 342

  Fly   200 NFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLP 264
            |..||:.::||||||..:|..::.||::||..||.:|:|:|.|:||::..|...|:.:|..:|||
Mouse   343 NIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLP 407

  Fly   265 LLSPKFLVGTVGSDL----LVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLF 325
            ||.|:.|     :||    |.::|..|:.|:.||..|.|||:.|.|||.|||:|||.|  ...|:
Mouse   408 LLPPQIL-----ADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKST--VGTLY 465

  Fly   326 AVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYD 390
            ||||..:.....::|::|.:||.|.....|:.||...||||::|.|:.:||.||...||::|.|:
Mouse   466 AVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYN 530

  Fly   391 PQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRL 455
            |:|..|:. :.|.::.|..:||.||:|.:|||||.||...||.|||:||:..:|:.||.|:..|.
Mouse   531 PKTKTWTV-LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARS 594

  Fly   456 GVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRD 520
            .|.||.|.|.||::||.||...|:::|.|||..|||...:||..||..:|.|..:.::|||||.|
Mouse   595 TVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHD 659

  Fly   521 -----DCME-LSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYD 579
                 .|.. |...|||:|.|:||:.:..::..|..||:.::..:||||||:||..||.|:|.||
Mouse   660 APASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYD 724

  Fly   580 PETNQWRLCGCMNYRRLGGGVGVMRAP 606
            |:||:|.....:|..|.|..|.|::.|
Mouse   725 PQTNEWTQMASLNIGRAGACVVVIKQP 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	54/132 (41%)
		PHA03098	69..587	CDD:222983	236/527 (45%)
		KELCH repeat	359..403	CDD:276965	18/43 (42%)
		KELCH repeat	407..451	CDD:276965	23/43 (53%)
		KELCH repeat	454..497	CDD:276965	20/42 (48%)
		KELCH repeat	501..545	CDD:276965	18/49 (37%)
		KELCH repeat	548..593	CDD:276965	21/44 (48%)
Klhl1	NP_444335.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..98
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..184		7/30 (23%)
		BTB	205..308	CDD:279045	45/102 (44%)
		PHA03098	209..731	CDD:222983	235/529 (44%)
		BACK	317..416	CDD:285009	46/103 (45%)
		Kelch 1	463..509		17/45 (38%)
		Kelch	464..509	CDD:128874	17/44 (39%)
		Kelch_1	498..543	CDD:279660	20/45 (44%)
		KELCH repeat	499..542	CDD:276965	18/43 (42%)
		Kelch 2	510..556		18/46 (39%)
		KELCH repeat	546..590	CDD:276965	23/43 (53%)
		Kelch	558..603	CDD:128874	23/44 (52%)
		Kelch 3	558..603		23/44 (52%)
		KELCH repeat	593..636	CDD:276965	20/42 (48%)
		Kelch	604..650	CDD:128874	20/45 (44%)
		Kelch 4	604..650		20/45 (44%)
		KELCH repeat	640..690	CDD:276965	18/49 (37%)
		Kelch	652..703	CDD:128874	18/50 (36%)
		Kelch 5	652..703		18/50 (36%)
		KELCH repeat	693..737	CDD:276965	21/43 (49%)
		Kelch 6	704..750		23/45 (51%)
		Kelch	704..748	CDD:128874	22/43 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820